Leonid M. Litvak

Current focusing and steering: Modeling, physiology, and psychophysics

Current steering and current focusing are stimulation techniques designed to increase the number of distinct perceptual channels available to cochlear implant (CI) users by adjusting currents applied simultaneously to multiple CI electrodes. Previous studies exploring current steering and current focusing stimulation strategies are reviewed, including results of research using computational models, animal neurophysiology, and human psychophysics. Preliminary results of additional neurophysiological and human psychophysical studies are presented that demonstrate the success of current steering strategies in stimulating auditory nerve regions lying between physical CI electrodes, as well as current focusing strategies that excite regions narrower than those stimulated using monopolar configurations. These results are interpreted in the context of perception and speech reception by CI users. Disparities between results of physiological and psychophysical studies are discussed. The differences in stimulation used for physiological and psychophysical studies are hypothesized to contribute to these disparities. Finally, application of current steering and focusing strategies to other types of auditory prostheses is also discussed.

Relationship between perception of spectral ripple and speech recognition in cochlear implant and vocoder listeners

Spectral resolution has been reported to be closely related to vowel and consonant recognition in cochlear implant (CI) listeners. One measure of spectral resolution is spectral modulation threshold (SMT), which is defined as the smallest detectable spectral contrast in the spectral ripple stimulus. SMT may be determined by the activation pattern associated with electrical stimulation. In the present study, broad activation patterns were simulated using a multi-band vocoder to determine if similar impairments in speech understanding scores could be produced in normal-hearing listeners. Tokens were first decomposed into 15 logarithmically spaced bands and then re-synthesized by multiplying the envelope of each band by matched filtered noise. Various amounts of current spread were simulated by adjusting the drop-off of the noise spectrum away from the peak (40-5 dBoctave). The average SMT (0.25 and 0.5 cyclesoctave) increased from 6.3 to 22.5 dB, while average vowel identification scores dropped from 86% to 19% and consonant identification scores dropped from 93% to 59%. In each condition, the impairments in speech understanding were generally similar to those found in CI listeners with similar SMTs, suggesting that variability in spread of neural activation largely accounts for the variability in speech perception of CI listeners.

Spectral modulation detection and vowel and consonant identifications in cochlear implant listenersa)

Speech understanding by cochlear implant listeners may be limited by their ability to perceive complex spectral envelopes. Here, spectral envelope perception was characterized by spectral modulation transfer functions in which modulation detection thresholds became poorer with increasing spectral modulation frequency (SMF). Thresholds at low SMFs, less likely to be influenced by spectral resolution, were correlated with vowel and consonant identifications [Litvak, L. M. et al. (2008). J. Acoust. Soc. Am. 122, 982-991] for the same listeners; while thresholds at higher SMFs, more likely to be affected by spectral resolution, were not. Results indicate that the perception of broadly spaced spectral features is important for speech perception.

Signal processing strategies for cochlear implants using current steering

In contemporary cochlear implant systems, the audio signal is decomposed into different frequency bands, each assigned to one electrode. Thus, pitch perception is limited by the number of physical electrodes implanted into the cochlea and by the wide bandwidth assigned to each electrode. The Harmony HiResolution bionic ear (Advanced Bionics LLC, Valencia, CA, USA) has the capability of creating virtual spectral channels through simultaneous delivery of current to pairs of adjacent electrodes. By steering the locus of stimulation to sites between the electrodes, additional pitch percepts can be generated. Two new sound processing strategies based on current steering have been designed, SpecRes and SineEx. In a chronic trial, speech intelligibility, pitch perception, and subjective appreciation of sound were compared between the two current steering strategies and standard HiRes strategy in 9 adult Harmony users. There was considerable variability in benefit, and the mean results show similar performance with all three strategies.

Use of Phantom Electrode Technique to Extend the Range of Pitches Available Through a Cochlear Implant

Objective: The range of pitch sensations available in cochlear implants (CIs) is conventionally thought to be limited by the location of the most apical and basal electrodes. However, partial bipolar stimulation, in which current is distributed to two intracochlear electrodes and one extracochlear electrode, can produce “phantom electrode” (PE) pitch percepts that extend beyond the pitch range available with physical electrodes. The goals of this study were (1) to determine the PE configuration that generated the lowest pitch relative to monopolar (MP) stimulation of the most apical electrode and (2) to determine the amount of pitch shift produced by different PE configurations. Design: Ten Advanced Bionics CI users (9 unilateral and 1 bilateral), implanted with the CII or HiRes 90k implant and the HiFocus 1, HiFocus 1j, or Helix electrode arrays participated in this study. PEs were created by simultaneously stimulating the primary and compensating electrodes in opposite phase. To test different PE configurations, the proportion of current delivered to the compensating electrode (σ) and the electrode separation between the primary and compensatory electrode (D) were varied. To estimate the relative pitch of PEs, the lowest pitched PEs with primary electrodes 4 and 8 were compared with subsets of MP electrodes (1, 2, 3, 4, 5 and 5, 6, 7, 8, 9, respectively). Results: In all subjects, it was possible to identify σ and D values that produced a PE that was lower in pitch than the MP stimulation of the primary electrode. In some subjects, increasing σ and/or D produced progressively lower pitch percepts, whereas in others, PE pitch changed nonmonotonically with σ and/or D. The amount of PE pitch shift could be estimated only for 14 cases; in seven cases, the pitch shift was <1 MP electrode, and in seven other cases, the pitch shift was between 1 and 2 MP electrodes. Conclusions: PE stimulation can elicit pitch percepts lower than that of the most apical MP electrode; the PE pitch is lower by the equivalent of 0.5 to 2 MP electrodes.

Excitation Patterns of Simultaneous and Sequential Dual-Electrode Stimulation in Cochlear Implant Recipients

Objective: Both simultaneous (SI) and sequential stimulation of intracochlear electrodes can be used to generate pitches that are intermediate to the physical electrodes (PEs). The goal of this study was to compare the spread of neural excitation for SI and sequential dual-electrode stimulation with the spread of neural excitation for the intermediate electrode using electrically evoked compound action potentials. Design: Seven Advanced Bionics cochlear implant users with either CII or HiRes 90k implant and HiFocus 1 or HiFocus 1j electrode array participated in this study. A masker-probe subtraction method was used to derive neural excitation patterns for SI nonadjacent dual-electrode stimulation, apical and basal-first sequential nonadjacent dual-electrode stimulation, and the intermediate PE. For apical-first sequential (SEa) stimulation, the masker pulse on the apical electrode immediately preceded the masker pulse on the basal electrode, and vice versa for basal-first sequential stimulation (SEb). The electrodes used for dual-electrode stimulation were separated by an intermediate PE, which represents a spatial distance of approximately 2 mm. Current levels necessary to achieve comfortable loudness were determined for each masker and probe stimulus. During the evoked compound action potential measurements, the masker was fixed in location, whereas the probe was varied across a subset of electrodes in the array. Neural responses were calculated by subtracting the response to the probe from the masked response. Results: Neural excitation patterns were normalized to their peak and analyzed in terms of their area and center of gravity. The area and center of gravity for SI nonadjacent dual-electrode stimulation were similar to those of the intermediate PE. In contrast, the area for the two modes of sequential nonadjacent dual-electrode (SEa and SEb) stimulation differed significantly from the intermediate PE. The center of gravity for SEa stimulation also differed significantly from the intermediate PE, whereas there was no significant difference in the center of gravity between SEb stimulation and the intermediate PE. Conclusions: Peripheral neural activation patterns suggest a similar spread of excitation for SI dual-electrode stimulation and the intermediate PE. The spread of excitation associated with sequential dual-electrode stimulation is generally different from the intermediate PE, and it varies depending on the order of the sequential pulses.

Electrocochleography in Cochlear Implant Recipients With Residual Hearing: Comparison With Audiometric Thresholds.

Objectives: To determine whether electrocochleography (ECoG) thresholds, especially cochlear microphonic and auditory nerve neurophonic thresholds, measured using an intracochlear electrode, can be used to predict pure-tone audiometric thresholds following cochlear implantation in ears with residual hearing. Design: Pure-tone audiometric thresholds and ECoG waveforms were measured at test frequencies from 125 to 4000 Hz in 21 Advanced Bionics cochlear implant recipients with residual hearing in the implanted ear. The “difference” and “summation” responses were computed from the ECoG waveforms measured from two alternating phases of stimulation. The interpretation is that difference responses are largely from the cochlear microphonic while summating responses are largely from the auditory nerve neurophonic. The pure-tone audiometric thresholds were also measured with same equipment used for ECoG measurements. Results: Difference responses were observed in all 21 implanted ears, whereas summation response waveforms were observed in only 18 ears. The ECoG thresholds strongly correlated (r2 = 0.87, n = 150 for difference response; r2 = 0.82, n = 72 for summation response) with audiometric thresholds. The mean difference between the difference response and audiometric thresholds was −3.2 (±9.0) dB, while the mean difference between summation response and audiometric thresholds was −14 (±11) dB. In four out of 37 measurements, difference responses were measured to frequencies where no behavioral thresholds were present. Conclusions: ECoG thresholds may provide a useful metric for the assessment of residual hearing in cochlear implant subjects for whom it is not possible to perform behavioral audiometric testing.

Design and Evaluation of a Cochlear Implant Strategy Based on a “Phantom” Channel

Unbalanced bipolar stimulation, delivered using charge balanced pulses, was used to produce “Phantom stimulation”, stimulation beyond the most apical contact of a cochlear implant’s electrode array. The Phantom channel was allocated audio frequencies below 300Hz in a speech coding strategy, conveying energy some two octaves lower than the clinical strategy and hence delivering the fundamental frequency of speech and of many musical tones. A group of 12 Advanced Bionics cochlear implant recipients took part in a chronic study investigating the fitting of the Phantom strategy and speech and music perception when using Phantom. The evaluation of speech in noise was performed immediately after fitting Phantom for the first time (Session 1) and after one month of take-home experience (Session 2). A repeated measures of analysis of variance (ANOVA) within factors strategy (Clinical, Phantom) and interaction time (Session 1, Session 2) revealed a significant effect for the interaction time and strategy. Phantom obtained a significant improvement in speech intelligibility after one month of use. Furthermore, a trend towards a better performance with Phantom (48%) with respect to F120 (37%) after 1 month of use failed to reach significance after type 1 error correction. Questionnaire results show a preference for Phantom when listening to music, likely driven by an improved balance between high and low frequencies.

Loudness and pitch perception using Dynamically Compensated Virtual Channels.

&NA; Reducing power consumption is important for the development of smaller cochlear implant (CI) speech processors. Simultaneous electrode stimulation may improve power efficiency by minimizing the required current applied to a given electrode. Simultaneous in‐phase stimulation on adjacent electrodes (i.e. virtual channels) can be used to elicit pitch percepts intermediate to the ones provided by each of the physical electrodes in isolation. Virtual channels are typically implemented in monopolar stimulation mode, producing broad excitation patterns. Focused stimulation may reduce the excitation patterns, but is inefficient in terms of power consumption. To create a more power efficient virtual channel, we developed the Dynamically Compensated Virtual Channel (DC‐VC) using four adjacent electrodes. The two central electrodes are current steered using the coefficient Symbol (Symbol) whereas the two flanking electrodes are used to focus/unfocus the stimulation with the coefficient Symbol (Symbol). With increasing values of Symbol, power can be saved at the potential expense of generating broader electric fields. Additionally, reshaping the electric fields might also alter place pitch coding. Symbol. No caption available. Symbol. No caption available. Symbol. No caption available. Symbol. No caption available. The goal of the present study is to investigate the tradeoff between place pitch encoding and power savings using simultaneous electrode stimulation in the DC‐VC configuration. A computational model and psychophysical experiments in CI users have been used for that purpose. Results from 10 adult Advanced Bionics CI users have been collected. Results show that the required current to produce comfortable levels is significantly reduced with increasing Symbol as predicted by the computational model. Moreover, no significant differences in the estimated number of discriminable steps were detected for the different values of Symbol. From these results, we conclude that DC‐VCs can reduce power consumption without decreasing the number of discriminable place pitch steps. HighlightsDynamically Compensated Virtual Channels (DC‐VC), a new stimulation mode for CIs.Loudness and pitch perception with DC‐VC are investigated using a model and experiments in CI users.DC‐VC can be used to reduce power consumption without degradation of pitch perception.

Enhanced hearing in noise for cochlear implant recipients: clinical trial results for a commercially available speech-enhancement strategy.

Objective To demonstrate benefits for speech perception and everyday listening in quiet and in noise with a speech-enhancement strategy called ClearVoice, which was designed to improve listening in complex acoustic environments without compromising hearing in quiet. Study Design A 2-week randomized crossover design was used to evaluate ClearVoice in 46 adults unilaterally implanted with a CII/HiRes 90K cochlear implant who had at least 6 months experience with HiRes Fidelity 120 sound processing. Speech perception was assessed using the AzBio sentences presented in quiet, in speech-spectrum noise and in multitalker babble. Subjective listening benefit and strategy preference were assessed with a questionnaire. ClearVoice has 3 gain settings (low, medium, and high), each intended as a full-time listening option according to individual preference. Speech understanding after acute use of ClearVoice-low was compared with HiRes Fidelity 120 during an initial test session. Speech perception abilities were compared with HiRes Fidelity 120 after 2 weeks of exclusive use of ClearVoice-medium, and after 2 weeks of exclusive use of ClearVoice-high. During a fifth week, participants were fit with 3 programs for comparison (HiRes Fidelity 120, ClearVoice-medium, and ClearVoice-high), after which, they reported preference and everyday listening benefits via a questionnaire. Results ClearVoice significantly improved speech understanding in speech-spectrum noise and multitalker babble, did not compromise listening in quiet, was preferred for everyday listening, and provided improved hearing in real-life situations. Conclusion ClearVoice improves hearing in noise for cochlear implant recipients who use HiRes Fidelity 120 sound processing.