Lewis R. Eversole

Benign neural sheath neoplasm of the oral cavity: Report of thirty-seven cases

Abstract Thirty-seven cases of neurilemmoma and neurofibroma have been presented. Histologic variations occur within these two types of neoplasm, including myxoid, collagenized, and plexiform varieties of neurofibroma, and classic, Verocay, plexiform, and ancient forms of neurilemmoma. Females are more commonly affected and younger persons are predisposed. Twenty per cent of the neurofibromas were associated with von Recklinghausens neurofibromatosis.

Histogenesis of odontogenic tumors

Abstract A theoretical presentation concerning the histogenesis of mixed odontogenic tumors in relation to tooth germ embryogenesis is discussed. It is proposed that the individual tumors that make up this group are solely and totally dependent upon the presence of differentiation factors which are or are not elaborated by a particular tumor. The probability of sequential differentiating events resulting in the progression of an immature entity (ameloblastic fibroma) to a highly differentiated entity (odontoma) has been discounted, with reservations. Rather, it is postulated that individual mixed odontogenic tumors arise at comparable stages observed during normal odontogenesis and, as such, are incapable of further differentiation and thus proliferate within the histologic confines of their innate differentiated capacity.

Ancient neurilemmoma of the oral cavity

Abstract A case of ancient neurilemmoma arising in oral soft tissues displays features in common with a similar, if not identical, tumor encountered in the thorax. It is suggested that the histologic features typifying this tumor are degenerative changes occurring as a manifestation of longevity in what was at one time a neurilemmoma in the classic sense.

Central and peripheral fibrogenic and neurogenic sarcoma of the oral regions

Abstract Sixty-three instances of fibrosarcoma and neurogenic sarcoma of the oral regions are reviewed and two cases are presented. Twenty peripheral oral fibrosarcomas and twenty-four fibrosarcomas central in the mandible displayed a predilection for males and were more often encountered during the third through fifth decades of life. Peripheral fibrosarcoma enjoyed a more favorable 5-year survival rate than did central fibrosarcoma. No sex predilection occurred, and most patients were afflicted in the third through fifth decades of life. A meaningful analysis of survival rates could not be made for oral neurogenic sarcoma. A propensity for neurogenic sarcoma of the inferior alveolar nerve to proliferate for great distances along the nerve trunk was noted.

Oral lesions as the initial sign in pemphigus vulgaris

Abstract The histopathologic features of pemphigus vulgaris are quite characteristic; however, other diseases may display intraepithelial vesiculation and acantholysis. In the case presented here, indirect immunofluorescent staining was used as an adjunctive diagnostic procedure that confirmed the diagnosis of pemphigus vulgaris which at this time was confined to oral mucous membrane.

Medulloblastoma: Extradural metastasis to the jaw: Report of a case

Abstract A metastatic focus of medulloblastoma in the mandible of an 11-year-old girl is presented. This represents the second documented instance of remote spread to the jaws from a malignant tumor of the central nervous system.

Autosomal recessive hypohidrotic ectodermal dysplasia: Dental manifestations

Abstract Hypodontia, together with other characteristics similar in each of three sisters, established a diagnosis of anhidrotic ectodermal dysplasia. The clinical features of the patients are described, and the oral and dental manifestations are presented. The parents were found to be free of all the aberrant conditions described in the proband.

Diphenylhydantoin Sodium (Dilantin) as a Caries Retarder

Rats that had their mandibular first molars silk-ligated and that were fed chow with diphenylhydantoin sodium (Dilantin) developed less caries than rats that were not fed Dilantin. The retarding effect of Dilantin was enhanced by the cleanliness of the environment in which the animals lived.

The enzyme histochemistry of isoproterenol-induced salivary gland hyperplasia

Abstract Recent biochemical studies in isoproterenol (ISOP)-induced salivary gland hyperplasia have shown that ISOP selectively enhanced the appearance of enzymes necessary for the synthesis of DNA. These studies have prompted a histochemical investigation of the enzyme activities in ISOP-induced salivary gland hyperplasia in the rat. Diminished activity of cytoplasmic oxidases—glucose-6-phosphate dehydrogenase, alpha-glycerophosphate dehydrogenase, and lactate dehydrogenase—was noted in the secretory ducts of ISOP-treated animals. Slight reduction of mitochondrial oxidases, namely, succinate dehydrogenase, NADH diaphorase, and cytochrome oxidase, was noted in both excretory and secretory ducts of ISOP-treated animals. Hydrolytic enzyme activity was, for the most part, similar in control and experimental animals.