William R. Sabes

Aggressive growth and neoplastic potential of odontogenic cysts: with special reference to central epidermoid and mucoepidermoid carcinomas.

An aggressive form of odontogenic cyst known as the keratocyst has been reviewed with a report on the findings of 70 new instances. Recurrence after 2 years of followup was found to be 20%. From both a review of the literature and original cases, carcinomatous and ameloblastomatous transformation in odontogenic keratocysts seems to be an extremely rare phenomenon. Alternatively, epidermoid carcinoma and mucoepidermoid carcinoma arising centrally within the jaws are often associated with other types of dental cysts. Review of 36 instances of central epidermoid carcinoma has disclosed that 75% were associated with a cyst lining; the 2‐year survival rate was found to be 53%. Central mucoepidermoid carcinoma was associated with a dental cyst or impacted tooth in 48% of the cases, and enjoyed a 100% 2‐year and 5‐year survival; however, 2 patients were recorded alive with disease at 4 months and 10 years, whereas another patient succumbed to disease 14 years post‐operatively.

Central and peripheral fibrogenic and neurogenic sarcoma of the oral regions

Abstract Sixty-three instances of fibrosarcoma and neurogenic sarcoma of the oral regions are reviewed and two cases are presented. Twenty peripheral oral fibrosarcomas and twenty-four fibrosarcomas central in the mandible displayed a predilection for males and were more often encountered during the third through fifth decades of life. Peripheral fibrosarcoma enjoyed a more favorable 5-year survival rate than did central fibrosarcoma. No sex predilection occurred, and most patients were afflicted in the third through fifth decades of life. A meaningful analysis of survival rates could not be made for oral neurogenic sarcoma. A propensity for neurogenic sarcoma of the inferior alveolar nerve to proliferate for great distances along the nerve trunk was noted.

Oral lesions as the initial sign in pemphigus vulgaris

Abstract The histopathologic features of pemphigus vulgaris are quite characteristic; however, other diseases may display intraepithelial vesiculation and acantholysis. In the case presented here, indirect immunofluorescent staining was used as an adjunctive diagnostic procedure that confirmed the diagnosis of pemphigus vulgaris which at this time was confined to oral mucous membrane.

Sialadenoma papilliferum of the oral cavity

Sialadenoma papilliferum is a rare tumor of salivary gland origin. A review of the English-language literature indicates that only four cases have been reported. This article describes the clinical and histologic characteristics of an additional case occurring on the left retromolar pad.

Ameloblastic adenomatoid tumor

Abstract Twenty-nine cases of ameloblastic adenomatoid tumor were presented in the dental literature from 1962 to 1965. Of these, twenty-eight were reported as adenoameloblastoma. Sixteen occurred in females, and the maxilla was involved twice as often as the mandible. In the present article we have presented a case of ameloblastic adenomatoid tumor affecting the mandible of a 16-year-old boy. We advocate the use of the term ameloblastic adenomatoid tumor to prevent confusion of this tumor with a variety of ameloblastoma, which may result in unnecessary extensive surgical intervention.

Medulloblastoma: Extradural metastasis to the jaw: Report of a case

Abstract A metastatic focus of medulloblastoma in the mandible of an 11-year-old girl is presented. This represents the second documented instance of remote spread to the jaws from a malignant tumor of the central nervous system.

Intraoral melanocytic cellular nevi

Eight cases of intraoral melanocytic cellular nevi are presented, together with the clinical features and limited follow-up information. These cases are added to those already published, so that a meaningful series may eventually be analyzed.

Patient response to variations in denture technique. Part V: Microscopic response of the oral mucosa.

The purpose of this study was to determine the effects of two different denture construction techniques on the maturation of the oral mucosa. Complete maxillary and mandibular dentures were constructed for 64 patients. Half of the subjects received dentures fabricated by a complex technique, and the remaining subjects received dentures fabricated by a standard technique. Cytologic smears were made from four regions of the denture-bearing mucosa at yearly intervals for 5 years following construction of the dentures. The smears were stained by the Papanicolaou technique. Microscopic analysis based on cytologic characteristic revealed no discernible difference between the mucosa of those subjects with dentures constructed via the complex technique and that of those with dentures constructed via the standard technique.

Diphenylhydantoin Sodium (Dilantin) as a Caries Retarder

Rats that had their mandibular first molars silk-ligated and that were fed chow with diphenylhydantoin sodium (Dilantin) developed less caries than rats that were not fed Dilantin. The retarding effect of Dilantin was enhanced by the cleanliness of the environment in which the animals lived.