Li-Ming Yang Kuo
Taipei Medical University
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Publication
Featured researches published by Li-Ming Yang Kuo.
Journal of Traditional and Complementary Medicine | 2012
Pen-Ho Yeh; Yun-Dar Shieh; Li-Chun Hsu; Li-Ming Yang Kuo; Jhih-Hu Lin; Chia-Ching Liaw; Yao-Haur Kuo
Bioassay-guided fractionation of the EtOH extract of the dried twigs of Podocarpus nakaii Hayata (Podocarpaceae), endemic plant in Taiwan has resulted in isolation of four [3′→8″]-biflavonoid derivatives, amenotoflavone (AF), podocarpusflavone-A (PF), II-4″,I-7-dimethoxyamentoflavone (DAF), and heveaflavone (HF). Their structures were determined by physical and extensive spectroscopic analyses such as 1H, 13C, 1H-1H COSY, HMQC, and HMBC, as well as comparison with literature values. Compounds PF and DAF showed significant inhibitions against DLD, KB, MCF-7, HEp-2 tumor cell lines (ED50 ca. 4.56-16.24 μg/mL) and induced cell apoptosis in MCF-7 via mainly sub-G1/S phase arrest. Furthermore, these compounds exhibited moderate Topoisomerase I inhibitory activity.
Journal of Traditional and Complementary Medicine | 2011
Li-Jie Zhang; Sheau-Farn Yeh; Ya-Ten Yu; Li-Ming Yang Kuo; Yao-Haur Kuo
Two new flavonol glucuronides, quercetin 3-O-β-D-2″-acetylglucuronide (1) and quercetin 3-O-β-D-2″-acetylglucuronide methyl ester (2), along with four known flavonoids (3-6) were isolated from the whole parts of Rotala rotundifolia. The structures of 1 and 2 were elucidated by application of various spectroscopic methods, including 1D and 2D NMR techniques. Biological evaluation showed that all of isolated flavonoid compounds have potent anti-oxidative activities by DPPH and superoxide anion methods, and kaempferol (3) and quercetin (4) exhibited significant anti-HBV activity assayed by anti-HBsAg production. The HPLC fingerprint with photodiode array detection (HPLC-DAD) for quality control of R. rotundifolia partitioned EtOAc layer was also established.
Planta Medica | 2018
Li-Ming Yang Kuo; Pei-Yi Tseng; Yu-Chi Lin; Chia-Ching Liaw; Li-Jie Zhang; Keng-Chang Tsai; Zhi-Hu Lin; Hsiu O. Ho; Yao-Haur Kuo
Phytochemical investigation of ethanol extracts from two Taiwanese collections of Vernonia cinerea resulted in the isolation of eighteen hirsutinolide-type sesquiterpenoids, including seven new ones designated as vernolides E - K (1: -7: ). All structures were determined by a combination of detailed spectroscopic analyses (NMR and MS) and comparison with reported data. In an in vitro anti-inflammatory assay, compounds 3, 7, 9, 11: , and 14: exhibited strong inhibitory activities toward NO production by LPS-induced RAW264.7 macrophages, with IC50 values of 1.18, 0.85, 0.66, 0.71 and 0.45 µM, respectively, without affecting cellular viability at 40 µM. Preliminary structure-activity relationships indicate that the ester groups at C-8 and C-13 may enhance inhibition of NO production.
Chemical & Pharmaceutical Bulletin | 2003
Yao-Haur Kuo; Yu-Jen Kuo; Ang-Su Yu; Ming-Der Wu; Chi-Wi Ong; Li-Ming Yang Kuo; Jo-Ti Huang; Chieh-Fu Chen; Shyh-Yuan Li
Chemical & Pharmaceutical Bulletin | 2003
Ming-Der Wu; Ray-Ling Huang; Li-Ming Yang Kuo; Chia-Cheng Hung; Chi-Wi Ong; Yao-Haur Kuo
Journal of Agricultural and Food Chemistry | 2011
Li-Jie Zhang; Hui-Kang Liu; Ping-Chun Hsiao; Li-Ming Yang Kuo; I-Jung Lee; Tian Shung Wu; Wen-Fei Chiou; Yao-Haur Kuo
Bioorganic & Medicinal Chemistry | 2005
Chia-Cheng Hung; Wei-Jen Tsai; Li-Ming Yang Kuo; Yao-Haur Kuo
Journal of Natural Products | 2005
Yao-Haur Kuo; Ya-Wen Hsu; Chia-Ching Liaw; Jiun Kuan Lee; Hui-Chi Huang; Li-Ming Yang Kuo
Planta Medica | 2005
Li-Ming Yang Kuo; Kuei-Yuh Chen; Shy-Yuan Hwang; Jin-Liang Chen; Yen-Yin Liu; Chia-Ching Liaw; Po-Ho Ye; Cheng-Jen Chou; Chien-Chang Shen; Yao-Haur Kuo
Chemical & Pharmaceutical Bulletin | 2002
Yao-Haur Kuo; Shy-Yuan Hwang; Li-Ming Yang Kuo; Yi-Ling Lee; Shyh-Yuan Li; Ya-Ching Shen