Liangce Rong

An efficient multicomponent reaction for synthesis of 4-amino-6-aryl-2-alkylthiopyrimidine-5-carbonitrile derivatives

AbstractsAn efficient and facile synthesis of thiosubstituted pyrimidine derivatives (4-amino-6-aryl-2-alkylthiopyrimidine-5-carbonitrile derivatives) by one-pot multicomponent reaction of aromatic aldehydes, malononitrile, and S-methylisothiouronium sulfate (or S-benzylisothiourea hydrochloride) in ethanolic NaOH is reported. Because of the simple work-up procedure, low cost, and, especially, high product yields, this method is a useful and attractive procedure for synthesis of these thiosubstituted pyrimidine compounds.

I2-Catalyzed three-component procedure for synthesis of substituted spiro[indoline-3,7′-pyrano[3,2-c:5,6-c′]dichromene]-2,6′,8′-trione derivatives

We report a facile and efficient method for synthesis of substituted spiro[indoline-3,7′-pyrano[5,6-c:5,6-c′]dichromene]-2,6′,8′-trione derivatives by reaction of isatin and 4-hydroxy-2H-chromen-2-one. As far as we are aware, few methods have been reported for preparation of these compounds. The reaction proceeded smoothly when promoted by molecular iodine. Because it is a non-toxic, low cost, and readily available reagent, iodine is a green catalyst for synthesis of these spiroheterocyclic compounds. The other advantages of the procure are high yields, simple operation, atom economy, and mild reaction conditions.

Efficient Preparation of 5-Amino-4-cyano-N-(cyclopropylcarbamoyl)-3-aryl-2,3-dihydrothiophene-2-carboxamide Derivatives Without Using Any Other Catalysts

Abstract An efficient synthesis of 5-amino-4-cyano-N-(cyclopropylcarbamoyl)-3-aryl-2,3-dihydrothiophene-2-carboxamide derivatives by the reaction of thiazolidine-2,4-dione, aromatic aldehydes, malononitrile, and cyclopropylamine has been reported. This reaction could be carried out smoothly without using any other catalysts in anhydrous ethanol. The advantages of this procure were good yields, short reaction time, and mild reaction conditions. Moreover, the purification process of products was very simple. The products could be gained only as the reactants were cooled under room temperature, and the precipitate could be brought out. These precipitate only need to filter out, without further purification. Supplemental materials are available for this article. Go to the publishers online edition of Synthetic Communications® to view the free supplemental file. GRAPHICAL ABSTRACT

An efficient and green reaction of isatins, 3-amino-1-phenyl-2-pyrazolin-5-one (3-amine-1 H -pyrazole), and β -diketone in aqueous medium

An efficient and green reaction of isatins, 3-amino-1-phenyl-2-pyrazolin-5-one (3-amine-1H-pyrazole), and

An efficient synthesis of 3-aryl-2,3-dihydrothiophene-2-carboxamide derivatives by one-pot, four-component reaction

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Green metal-free synthesis of spiro-fused 3,4′-pyrazolo[4′,3′:5,6]pyrido[2,3-d]pyrimidine derivatives via deamination cyclization reactions in aqueous medium

β-diketone in aqueous medium in the presence of

CCDC 1524444: Experimental Crystal Structure Determination

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