Shimin Tao

An efficient and facile synthesis of novel substituted pyrimidine derivatives: 4-amino-5-carbonitrile-2-nitroaminopyrimidine

One-pot, multicomponent reaction for the synthesis of novel substituted pyrimidine derivatives: 4-amino-5-carbonitrile-2-nitroaminopyrimidine from aromatic aldehydes, 1-nitroguanidine, and malononitrile under ethanol is described. Because of containing many active functional groups, such as amino, cyan and nitro, these products are important intermediate of organic synthesis. The advantages of this procedure include the short reaction time, mild reaction conditions, and excellent yields.

An efficient and facile synthesis of polydentate ligand: pyridylpyrimidine-2-amine under solvent-free conditions

An efficient and facile synthesis of polydentate ligand pyridylpyrimidine-2-amine via a one-pot reaction of different aromatic aldehydes, 2-acetylpyridine and guanidine carbonate, in the presence of NaOH under solvent-free conditions, is reported. These compounds have four N-donors and they are classic polydentate ligands of many metal ions. Due to employing a one-pot, multicomponent reaction, this method offers several advantages including easy experimental work-up procedure, and lower cost, short reaction time, and especially high yields of products. This paper therefore develops a practical and convenient process for the synthesis of these ligands.

An efficient synthesis of 2-amino-4-aryl-6,7,8,9-tetrahydro-5H-benzo[7]annulene-1,3-dicarbonitriles in THF with DBU as catalyst

An efficient and convenient multicomponent reaction for preparation of 2-amino-4-aryl-6,7,8,9-tetrahydro-5H-benzo[7]annulene-1,3-dicarbonitrile derivatives, in THF, with DBU as catalyst is reported. These compounds are typical acceptor–donor–acceptor (A–D–A) systems comprising one electron donor and two electron acceptors with different important chemical properties. Excellent yields and the simplicity of the reaction procedure make this one of the most efficient methods for synthesis of these types of compound.

An efficient multicomponent reaction for synthesis of 4-amino-6-aryl-2-alkylthiopyrimidine-5-carbonitrile derivatives

AbstractsAn efficient and facile synthesis of thiosubstituted pyrimidine derivatives (4-amino-6-aryl-2-alkylthiopyrimidine-5-carbonitrile derivatives) by one-pot multicomponent reaction of aromatic aldehydes, malononitrile, and S-methylisothiouronium sulfate (or S-benzylisothiourea hydrochloride) in ethanolic NaOH is reported. Because of the simple work-up procedure, low cost, and, especially, high product yields, this method is a useful and attractive procedure for synthesis of these thiosubstituted pyrimidine compounds.

I2-Catalyzed three-component procedure for synthesis of substituted spiro[indoline-3,7′-pyrano[3,2-c:5,6-c′]dichromene]-2,6′,8′-trione derivatives

We report a facile and efficient method for synthesis of substituted spiro[indoline-3,7′-pyrano[5,6-c:5,6-c′]dichromene]-2,6′,8′-trione derivatives by reaction of isatin and 4-hydroxy-2H-chromen-2-one. As far as we are aware, few methods have been reported for preparation of these compounds. The reaction proceeded smoothly when promoted by molecular iodine. Because it is a non-toxic, low cost, and readily available reagent, iodine is a green catalyst for synthesis of these spiroheterocyclic compounds. The other advantages of the procure are high yields, simple operation, atom economy, and mild reaction conditions.

Efficient Preparation of 5-Amino-4-cyano-N-(cyclopropylcarbamoyl)-3-aryl-2,3-dihydrothiophene-2-carboxamide Derivatives Without Using Any Other Catalysts

Abstract An efficient synthesis of 5-amino-4-cyano-N-(cyclopropylcarbamoyl)-3-aryl-2,3-dihydrothiophene-2-carboxamide derivatives by the reaction of thiazolidine-2,4-dione, aromatic aldehydes, malononitrile, and cyclopropylamine has been reported. This reaction could be carried out smoothly without using any other catalysts in anhydrous ethanol. The advantages of this procure were good yields, short reaction time, and mild reaction conditions. Moreover, the purification process of products was very simple. The products could be gained only as the reactants were cooled under room temperature, and the precipitate could be brought out. These precipitate only need to filter out, without further purification. Supplemental materials are available for this article. Go to the publishers online edition of Synthetic Communications® to view the free supplemental file. GRAPHICAL ABSTRACT

An efficient synthesis of 3-aryl-2,3-dihydrothiophene-2-carboxamide derivatives by one-pot, four-component reaction

An efficient and convenient method for the preparation of 3-aryl-2,3-dihydr-othiophene-2-carboxamide derivatives in absolute ethyl alcohol by thiazolidine-2,4-dione, aromatic aldehyde, malononitrile and n-butylamine without using any other catalysts was reported. This methodology has the advantages of high yields, simple work-up procedure and mild reaction conditions.

An efficient and convenient one-pot multicomponent synthesis of novel pyrimidine derivatives: N-(4-aryl-6-(pyridin-2-yl)pyrimidin-2-yl)cyanamides

AbstractsAn efficient and facile synthesis of novel pyrimidine derivatives, N-(4-aryl-6-(pyridin-2-yl)pyrimidin-2-yl)cyanamides, via one-pot multicomponent reaction of different aromatic aldehydes, 2-acetylpyridine, and cyanoguanidine in the presence of NaOH in anhydrous EtOH is reported. Pyrimidine derivatives are extremely important six membered aromatic heterocyclic rings containing two nitrogen atoms which have a wide variety of important biologically activity. This method has the advantages of easy work-up, convenient purification, short reaction times, and high yields.

An efficient synthesis of 2-amino-4-aryl-3,5-dicarbonitrile-6-ethoxypyridine derivatives by the solvent taking part in the reaction

An efficient and facile synthesis of 2-amino-4-aryl-3,5-dicarbonitrile-6-ethoxypyridine via reaction of aromatic aldehydes, malononitrile, and ethanol in the presence of NaOH has been developed, without using the classic reagents amines and 1,3-dicarbonyl compounds. It is interesting that weak nucleophilic reagent ethanol could take part in the reaction without using strong base catalyst sodium ethylate. Compared with existing methods, the reported process has the advantages of excellent yields, easily obtainable raw materials, and mild reaction conditions.

An efficient and facile synthesis of inhibitors for hepatitis C viral and anti-SARS agents: 4-aryl-5-cyano-1,6-dihydro-2-thiouracils

One-pot, multicomponent reaction for the synthesis of 4-aryl-5-cyano-1,6-dihydro-2-thiouracils via three-component from aromatic aldehydes, ethyl 2-cyanoacetate and S-benzylisothiourea hydrochloride (methyl carbamimidothioate sulfate) under methanol is described. These compounds have many drug activities, such as anti-hepatitis C viral, anti-Severe acute respiratory syndrome and anti-HIV-1 integrese activity. The advantages of this procedure include the short reaction time, mild reaction conditions and excellent yields.