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Featured researches published by Lianna Sun.


Archives of Pharmacal Research | 2009

Timosaponin B-II inhibits pro-inflammatory cytokine induction by lipopolysaccharide in BV2 cells.

Wen-Quan Lu; Yan Qiu; Tiejun Li; Xia Tao; Lianna Sun; Wan-Sheng Chen

It was reported that the total polysaccharides extracts from Anemarrhenae asphodeloides Bge (Liliaceae, rhizome) could inhibit inflammatory responses in various models. In the present study, the effects of Timosaponin B-II, a purified extract from A. asphodeloidesb, on the expressions of IL-1β, TNF-α and IL-6, the activity of NF-κB and the activation of signal pathway related to NF-κB were explored in vitro. Timosaponin B-II significantly attenuated increase of these cytokines on both mRNA and protein levels from LPS-stimulated BV2 cells in a dose-dependent manner. The reporter gene assay also showed that the activation of NF-κB induced by LPS was inhibited by pre-treatment with Timosaponin B-II. Moreover, western blot results showed that the activation of p38, JNK and P65 had been decreased. These results suggest that both NF-κB signal pathway and MAPK pathway were involved in the inhibitory effects of Timosaponin B-II on the expression of pro-inflammatory cytokines.


Clinical and Experimental Pharmacology and Physiology | 2011

Antiplatelet and antithrombotic activities of timosaponin B-II, an extract of Anemarrhena asphodeloides

Wen-Quan Lu; Yan Qiu; Tiejun Li; Xia Tao; Lianna Sun; Wan-Sheng Chen

1. Antithrombotic agents are effective in the treatment of ischaemic stroke. Timosaponin B‐II (TB‐II) is a major active component of Anemarrhena asphodeloides Bunge (Liliaceae; rhizome) that has protective effects against cerebral ischaemic damage. The present study examined the antiplatelet and antithrombotic actions of TB‐II.


Fitoterapia | 2012

Three new sesquiterpenes from Tithonia diversifolia and their anti-hyperglycemic activity

Guijun Zhao; Xia Li; Wansheng Chen; Zhongxin Xi; Lianna Sun

Three new germacrane sesquiterpenes (1), (2), (3), along with eleven known sesquiterpenes, namely, tirotundin-3-O-methyl ether (4), deacetylvguiestin (5), 1β-hydroxydiversifolin-3-O-methyl ether (6), tagitinin C (7), 1β-hydroxytirotundin-3-O-methyl ether (8), 1β-hydroxytirotundin-1,3-O-dimethyl ether (9), tagitinin F-3-O-methyl ether (10), tagitinin F (11), tagitinin A (12), 3β-acetoxy-4α-hydroxyeduesm-11(13)-en-12-oic acid (13) and ilicic acid (14) were isolated from the aerial parts of Tithonia diversifolia. Their structures were established by spectroscopic analysis, while the relative configuration of compound 1 was confirmed by X-ray diffraction analysis. In addition, compounds 1-14 were evaluated in vitro for their anti-hyperglycemic activity by glucose uptake in 3T3-L1 adipocytes. It was found that 10μg/mL 1, 3, 6 and 8 could significantly increase glucose uptake without significant toxic effects.


Journal of Ethnopharmacology | 2013

The medicinal uses of Callicarpa L. in traditional Chinese medicine: an ethnopharmacological, phytochemical and pharmacological review.

Yanhua Tu; Lianna Sun; Meili Guo; Wansheng Chen

ETHNOPHARMACOLOGICAL RELEVANCE Callicarpa L. (Verbenaceae) has been used for centuries in Traditional Chinese Medicine (TCM) for the prevention and treatment of a wide number of health disorders such as inflammation, rheumatism, hematuria, fracture, hematemesis, menoxenia, gastrointestinal bleeding, scrofula, etc. AIMS OF THE REVIEW To assess the scientific evidence for therapeutic Callicarpa in TCM and to identify future research needs. METHODS The available information on the ethnopharmacological uses in Chinese medicine, phytochemistry, pharmacology and clinical practice of Callicarpa species was collected via a library and electronic search (PubMed, ScienceDirect, Google Scholar and CNKI). RESULTS A variety of ethnomedical use of Callicarpa has been recorded in many ancient Chinese books. Phytochemical investigation of this genus has resulted in identification of more than 200 chemical constituents, among which diterpenes, triterpenoids and flavonoids are the predominant groups. The isolates and crude extract have exhibited a wide spectrum of in vitro and in vivo pharmacological effects involving anti-inflammatory, hemostatic, neuroprotective, anti-amnesic, antitubercular, antioxidant, antimicrobial and analgesic activities. Preparations containing Callicarpa species exerted good efficacy on clinical applications of gynecological inflammation, internal and external hemorrhage as well as acne vulgaris and chronic pharyngitis, etc. From the toxicity perspective, only three Callicarpa species have been assessed. CONCLUSIONS Pharmacological results have validated the use of Callicarpa species in the traditional medicine. As literature demonstrated, terpenoids and flavonoids are perhaps responsible for most of the activities shown by the plants of this genus. However, the detailed active compounds and the underlying mechanisms remain a work in progress. In addition, more attention should be paid to C. nudiflora as well as the domain of rheumatism.


Journal of Pharmaceutical and Biomedical Analysis | 2015

Constituent analysis and quality control of Lamiophlomis rotata by LC-TOF/MS and HPLC-UV

Mingping La; Feng Zhang; Shouhong Gao; Xiaowei Liu; Zhi-Jun Wu; Lianna Sun; Xia Tao; Wansheng Chen

In the present study, chemical profile analysis for Lamiophlomis rotata, a classic Tibetan folk medicine, was illustrated by an ultra-high performance liquid chromatography quadrupole time-of-flight mass spectrometry (LC-TOF/MS) method, which provided evidence for the certain identification of the main constituents, including iridoids, flavonoids and phenylethanoid glycosides. Among these compounds, nine of them were regarded as marker compounds for the quantitative evaluation of L. rotata, using a simple and reliable method by HPLC with ultraviolet, in combination of chromatographic fingerprint analysis. Separation was achieved on a Waters SunFire C18 analytical column with linear gradient elution of acetonitrile and 0.1% formic acid aqueous solution. The validated method was successfully applied to evaluate twelve batches of L. rotata. Assay results showed that nine compounds did not vary significantly from the aerial parts and the whole plant for each batch, and was consistent with the fingerprint analysis, which confirmed the medicine parts alteration in Chinese Pharmacopoeia from the perspective of chemical components.


Planta Medica | 2013

Heracleifolinosides A-F, new triterpene glycosides from Cimicifuga heracleifolia, and their inhibitory activities against hypoxia and reoxygenation.

Yan-Ru Liu; Zhi-Jun Wu; Chuntong Li; Fengmin Xi; Lianna Sun; Wansheng Chen

Six new 9,19-cycloartane triterpene glycosides, heracleifolinosides A-F (1-6), and one new chromone, norkhelloside (7), were isolated from the rhizome of Cimicifuga heracleifolia, together with 15 known compounds (8-22). The structures of the new compounds were elucidated by means of spectroscopic methods including 2D NMR and mass spectrometry. The extracts of C. heracleifolia and all the isolated compounds were tested for activities against hypoxia and reoxygenation injury in human umbilical vein endothelial cells. Heracleifolinoside B (2) is effectively resistant to hypoxia and reoxygenation-induced human umbilical vein endothelial cell injury, with cell viabilities of 61.95 ± 2.04 %, 77.04 ± 4.44 %, and 83.65 ± 3.29 % at concentrations of 1, 10, and 100 µM, respectively.


Journal of Ethnopharmacology | 2014

Chemical profile- and pharmacokinetics-based investigation of the synergistic property of platycodonis radix in traditional Chinese medicine formula Shengxian decoction.

Feng Zhang; Qin Zhan; Shouhong Gao; Xin Dong; Bo Jiang; Lianna Sun; Xia Tao; Wansheng Chen

ETHNOPHARMACOLOGICAL RELEVANCE To investigate the synergistic property of Platycodonis radix (PG) in a classic traditional Chinese medicine (TCM) prescription Shengxian decoction (SXT) by combining chemical profile with pharmacokinetic analysis strategy. The synergized prescription consisted of Astragali radix, Anemarrhenae rhizoma, Bupleuri radix, and Cimicifuage rhizoma. MATERIALS AND METHODS Ultra-performance liquid chromatography/quadruple time-of-flight mass spectrometry (UPLC-Q-TOF/MS) was employed to investigate the chemical fingerprints of SXT and decreased SXT (SXT that removed Platycodonis radix, SXT-PG). A reliable LC-MS/MS method was developed to examine the pharmacokinetics of 9 marker compounds (including formononetin, calycosin-7-O-β-d-glucoside, ononin, caffeic acid, isoferulic acid, mangiferin, timosaponin E1, timosaponin B-II and timosaponin B) following oral administration of SXT and SXT-PG in rats. Both in vitro chemical profiles and in vivo pharmacokinetic parameters differences between SXT and SXT-PG were conducted. RESULTS By using UPLC-Q-TOF/MS method, a total of 25 compounds identified from SXT, including 13 triterpenoids, 5 caffeinic derivatives, 4 isoflavonoids and 3 xanthone glycosides. Comparing the chemical fingerprints between SXT and decreased SXT did not reveal significant difference in the chemical profile of other four TCMs. The improved pharmacokinetic profiles of mangiferin, timosaponin E1, timosaponin B-II and timosaponin B were found in SXT group, suggesting the quicker distribution and more effective absorption, when compared with those in the SXT-PG group. CONCLUSIONS These results indicated that PG did not increase the dissolution of synergized prescription when co-decocting, but guided the synergized prescription to target location, reflecting the courier role of PG, which was in line with the clinical principle of TCM. It also established a useful method for TCM synergistic property research.


Journal of Natural Products | 2010

Anti-ischemia steroidal saponins from the seeds of Allium fistulosum.

Wei Lai; Zhi-Jun Wu; Houwen Lin; Tiejun Li; Lianna Sun; Yifeng Chai; Wansheng Chen

Six new furostanol saponins (1-6), named fistulosaponins A-F, three known furostanol saponins (7-9), and seven known aromatic compounds were isolated from seeds of Welsh onion (Allium fistulosum). The structures of these compounds were characterized by spectroscopic analyses including 2D NMR spectroscopy, mass spectrometry, and acid hydrolysis. The protective effect of the saponins on hypoxia-induced human umbilical vein endothelial cell injury was evaluated.


Molecules | 2014

Polyphenols with Anti-Proliferative Activities from Penthorum Chinense Pursh

Doudou Huang; Yun Jiang; Wansheng Chen; Fengyan Yao; Lianna Sun

Two new polyphenols, penthorumin C (1) and 2,6-dihydroxyacetophenone-4-O-[4ꞌ,6ꞌ-(S)-hexahydroxydiphenoyl]-β-d-glucose (2), along with four known polyphenolic acids, pinocembrin-7-O-[4ꞌꞌ,6ꞌꞌ-hexahydroxydiphenoyl]-β-d-glucose(3), pinocembrin-7-O-[3ꞌꞌ-O-galloyl- 4ꞌꞌ,6ꞌꞌ-hexahydroxydiphenoyl]-β-d-glucose (4), thonningianin A (5), and thonningianin B (6) were isolated from Penthourm chinense. All compounds were evaluated for their anti-proliferative activity in HSC-T6 cells, and 2 and 5 showed significant activity, with IC50 values of 12.7 and 19.2 μM, respectively.


Chinese Journal of Natural Medicines | 2014

Fingerprint analysis of Zhimu-Huangbai herb pair and simultaneous determination of its alkaloids, xanthone glycosides and steroidal saponins by HPLC-DAD-ELSD

Feng Zhang; Qi Yang; Lianna Sun; Shouhong Gao; Xia Tao; Wansheng Chen

AIM To develop and validate a high performance liquid chromatography (HPLC) coupled with diode array and evaporative light scattering detectors (DAD-ELSD) method for the quantitative determination and fingerprint analysis of ten active constituents in three chemical classes (namely, xanthone glycosides, steroidal saponins, and alkaloids) in Zhimu-Huangbai herb pair (ZB). METHOD Chromatographic separation was performed on a Diamonsil C18 column (4.6 mm × 250 mm, 5 μm, Dikma) by gradient elution using acetic acid in acetonitrile solution at a flow rate of 1.0 mL·min(-1) at 260 nm. The drift tube temperature of ELSD was set to 60 °C and nebulizer gas pressure was 4.0 Bar. Method validation was performed to assure its linearity, limits of detection and quantification, precision, repeatability, stability, and accuracy. RESULTS The HPLC-DAD-ELSD method allowed the quantification of ten compounds (phellodendrine, jatrorrhizine, palmatine, berberine, neomangiferin, mangiferin, timosaponin E-I, timosaponin B-II, timosaponin B, and timosaponin A-III), and was successfully applied to fingerprint analysis for ten batches of ZB samples. CONCLUSION This was the first time to apply the combination of DAD and ELSD for the simultaneous determination of ten active ingredients in ZB. The results showed that the combination of quantitative analysis for marker ingredients and chemical fingerprint for the TCM herb pair provides a potentially powerful, widely introduced, and internationally accepted strategy for assessment of complex TCM formulas.

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Wansheng Chen

Second Military Medical University

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Zhongxin Xi

Second Military Medical University

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Feng Zhang

Second Military Medical University

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Zhi-Jun Wu

Second Military Medical University

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Doudou Huang

Second Military Medical University

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Guijun Zhao

Second Military Medical University

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Xia Li

Second Military Medical University

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Xia Tao

Second Military Medical University

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Tiejun Li

Second Military Medical University

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Guanghui Huang

Second Military Medical University

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