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Dive into the research topics where Lilian A. Radesca is active.

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Featured researches published by Lilian A. Radesca.


Synthetic Communications | 1997

Synthesis of HIV-1 Reverse Transcriptase Inhibitor DMP 266

Lilian A. Radesca; Young S. Lo; James R. Moore; Michael E. Pierce

Abstract Abstract: DMP 266, a potent non-nucleoside HIV-1 reverse transcriptase inhibitor was prepared in six steps starting from commercially available 4-chlorophenyl isocyanate. The racemic compound was formed very efficiently from N-tert-butoxycarbonyl-4-chloroaniline and resolution was accomplished via the (-)-camphanates. Present address: B. I. Chemical, Inc., P.O. BOX 1658, Petersburg, VA 23805, U.S.A.)


Journal of Organic Chemistry | 1998

Practical Asymmetric Synthesis of Efavirenz (DMP 266), an HIV-1 Reverse Transcriptase Inhibitor

Michael E. Pierce; Rodney L. Parsons; Lilian A. Radesca; Young Sek Lo; Stuart Silverman; James R. Moore; Qamrul Islam; Anusuya Choudhury; Joseph M. Fortunak; Dieu Nguyen; Chi Luo; Susan J. Morgan; Wayne P. Davis; Pat N. Confalone; Cheng-yi Chen; Richard D. Tillyer; Lisa F. Frey; Lushi Tan; Feng Xu; Dalian Zhao; Andrew S. Thompson; Edward G. Corley; Edward J. J. Grabowski; Robert A. Reamer; Paul J. Reider


Journal of the American Chemical Society | 1989

The [2 + 3] and [3 + 4] annulation of enones. Enantiocontrolled total synthesis of (-)-retigeranic acid

Tomas Hudlicky; Alison Fleming; Lilian A. Radesca


Journal of Organic Chemistry | 1996

Stereoselective Synthesis of HIV-1 Protease Inhibitor, DMP 323

Michael E. Pierce; Gregory D. Harris; Qamrul Islam; Lilian A. Radesca; Louis Storace; Robert E. Waltermire; Ed Wat; Prabhakar K. Jadhav; George C. Emmett


Organic Process Research & Development | 2006

Stereoselective process for a CCR3 antagonist

Tai-Yuen Yue; Douglas D. Mcleod; Kevin B. Albertson; Steven R. Beck; Joerg Deerberg; Joseph M. Fortunak; William A. Nugent; Lilian A. Radesca; Liya Tang; Cathie Dong Xiang


Journal of Organic Chemistry | 1986

New vinylcyclopropanation methodology and reagents for potential [2 + 3] cyclopentene, dihydrofuran, and pyrroline annulations

Tomas Hudlicky; Lilian A. Radesca; Hector Luna; Frank E. Anderson


Journal of Organic Chemistry | 1987

Menthyl 2-bromocrotonate and menthyl 4-bromocrotonate: reagents for chiral vinylogous Darzens and Reformatsky reactions

Tomas Hudlicky; Lilian A. Radesca; H. Lee Rigby


Journal of Natural Products | 1987

General method of synthesis for natural long-chain β-diketones

Graciela Barbieri; Gustavo Seoane; Jose-Luis Trabazo; Alejandro Riva; Francisco Umpierrez; Lilian A. Radesca; Ramon Tubio; Lawrence D. Kwart; Tomas Hudlicky


Archive | 2001

Asymmetric synthesis of quinazolin-2-ones useful as HIV reverse transcriptase inhibitors

Rodney L. Parsons; Roberta L. Dorow; Akin H. Davulcu; Joseph M. Fortunak; Gregory D. Harris; Goss S. Kauffman; William A. Nugent; Lilian A. Radesca


Journal of the American Chemical Society | 1989

The [2 + 3] and [3 + 4] annulation of enones. Enantiocontrolled total synthesis of (-)-retigeranic acid [Erratum to document cited in CA111(11):97589v]

Tomas Hudlicky; Alison Fleming; Lilian A. Radesca

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