Rodney L. Parsons
Bristol-Myers Squibb
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Publication
Featured researches published by Rodney L. Parsons.
Journal of Organic Chemistry | 2009
Akin H. Davulcu; Douglas D. McLeod; Jun Li; Kishta Katipally; Adam F. Littke; Wendel W. Doubleday; Zhongmin Xu; Cary W. McConlogue; Chiajen J. Lai; Margaret Gleeson; Mark D. Schwinden; Rodney L. Parsons
BMS-317180 (1) is a potent, orally active agonist of the human growth hormone secretagogue (GHS) receptor. This manuscript details the process research and development efforts that enabled the synthesis of the phosphate salt of 1 on a multi-kilogram scale. Key considerations in the development of this process focused on safe execution and the requirement for telescoped synthetic transformations (i.e., without isolation of intermediate products) to contend with a lack of suitably crystalline products.
Separation Science and Technology | 2011
Rodney L. Parsons; Scott A. Miller
Abstract Recent regulatory guidelines for the control of genotoxic impurities in pharmaceutical products have posed a significant challenge for the pharmaceutical industry. This chapter provides an overview of the regulatory requirements, evolution of the established exposure limits, assessment of genotoxic impurities, and the implementation and execution of an appropriate risk-based genotoxic control strategy. In addition, an overview of the analytical challenges, methodologies, and strategy for testing genotoxic impurities at trace levels in pharmaceutical products is provided.
Journal of Organic Chemistry | 1998
Michael E. Pierce; Rodney L. Parsons; Lilian A. Radesca; Young Sek Lo; Stuart Silverman; James R. Moore; Qamrul Islam; Anusuya Choudhury; Joseph M. Fortunak; Dieu Nguyen; Chi Luo; Susan J. Morgan; Wayne P. Davis; Pat N. Confalone; Cheng-yi Chen; Richard D. Tillyer; Lisa F. Frey; Lushi Tan; Feng Xu; Dalian Zhao; Andrew S. Thompson; Edward G. Corley; Edward J. J. Grabowski; Robert A. Reamer; Paul J. Reider
Organic Letters | 2000
Goss S. Kauffman; Gregory D. Harris; Roberta L. Dorow; Benjamin R. P. Stone; Rodney L. Parsons; Jaan A. Pesti; Nicholas A. Magnus; Joseph M. Fortunak; Pat N. Confalone; William A. Nugent
Organic Process Research & Development | 2005
Sridhar Desikan; Rodney L. Parsons; Wayne P. Davis; James E. Ward; Will J. Marshall; Pascal H. Toma
Journal of the American Chemical Society | 2004
Timothy F. Briggs; Mark D. Winemiller; David B. Collum; Rodney L. Parsons; Akin H. Davulcu; Gregory D. Harris; Joseph M. Fortunak; Pat N. Confalone
Journal of Organic Chemistry | 2003
Nicholas A. Magnus; Pat N. Confalone; Louis Storace; Mona Patel; Christopher C. Wood; Wayne P. Davis; Rodney L. Parsons
Organic Process Research & Development | 2002
Louis Storace; Luigi Anzalone; Pat N. Confalone; Wayne P. Davis; Joseph M. Fortunak; Mark Giangiordano; James J. Haley; Kenneth Kamholz; Hui-Yin Li; Philip Ma; William A. Nugent; Rodney L. Parsons; Patrick J. Sheeran; Charlotte E. Silverman; and Robert E. Waltermire; Christopher C. Wood
Journal of Organic Chemistry | 1993
Rodney L. Parsons; Jeffrey D. Berk; Martin E. Kuehne
Organic Process Research & Development | 2010
Lindsay A. Hobson; Otute Akiti; Subodh S. Deshmukh; Shannon Harper; Kishta Katipally; Chiajen J. Lai; Robert C. Livingston; Ehrlic Lo; Michael M. Miller; Srividya Ramakrishnan; Lifen Shen; Jan Spink; Srinivas Tummala; Chenkou Wei; Kana Yamamoto; John Young; Rodney L. Parsons
