Lina María Serna

An association study of bipolar mood disorder (type I) with the 5-HTTLPR serotonin transporter polymorphism in a human population isolate from Colombia.

The short variant of a functional length polymorphism in the promoter region of the serotonin transporter has been associated with several behavioural and psychiatric traits, including bipolar mood disorder. The same short allele has also been implicated as a modifier of the bipolar phenotype. Here we evaluate the etiologic/modifier role of this polymorphism in a case (N=103) / control (N=112) sample for bipolar mood disorder (type I) collected from an isolated South American population. We did not detect an association between bipolar disorder and the 5-HTT promoter polymorphism in this sample. However, an excess of the short allele was seen in younger cases and in cases with psychotic symptoms. When combined with data from the literature, the increased frequency of the short allele in patients with psychotic symptoms was statistically significant.

Infección urinaria adquirida en la comunidad en pacientes pediátricos: clínica, factores de riesgo, etiología, resistencia a los antibióticos y respuesta a la terapia empírica

Objetivos. Describir la presentacion clinica, factores de riesgo (FR), etiologia y patrones de resistencia bacterianos en pacientes pediatricos hospitalizadoscon infeccion del tracto urinario (ITU) de la comunidad. Explorar factores de riesgo en ITU por bacterias resistentes. Evaluar respuesta clinicaa la terapia empirica con aminoglucosidos y el protocolo institucional de antibioticos en ITU frente al perfil de sensibilidad de los aislamientos.Metodos. Estudio de corte trasversal entre febrero/2009-febrero/2011.Resultados: ingresaron 106 pacientes, 47 hombres (44,3%) vs. 59 mujeres (55,6%). El rango de edad mas frecuente en ambos sexos fue 1-12 meses(63.2%). La ITU febril se presento en el 78,7% de los hombres y en el 83,0% de las mujeres. Se encontraron FR en 59,4% de los pacientes y en el27,3% se presentaron dos o mas. Los principales agentes etiologicos fueron: Escherichia coli, Proteus mirabilis y Klebsiella pneumoniae; dos y 12 aislamientos(13.1%) expresaron β-lactamasas de espectro extendido (βLEE) o de tipo AmpC (presuntivo), respectivamente.

Tres casos de mieloma múltiple de novo después de trasplante renal

Light chain-associated kidney compromise is frequent in patients with monoclonal gammopathies; it affects the glomeruli or the tubules, and its most common cause is multiple myeloma. It may develop after a kidney transplant due to recurrence of a preexisting multiple myeloma or it can be a de novo disease manifesting as graft dysfunction and proteinuria. A kidney biopsy is always necessary to confirm the diagnosis.We describe three cases of kidney graft dysfunction due to multiple myeloma in patients without presence of the disease before the transplant.