Liping Wu
Xi'an Jiaotong University
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Chinese Medical Journal | 2015
Liping Wu; Liru Xun; Li Xu; Amir Hussain; Bingyin Shi
IntroductIon Autoimmunity is defined as, a condition characterized by a specific humoral or cell‐mediated immune response against the constituents of the body’s own tissues (autoantigens). In numerous autoimmune diseases, such an immune response is well recognized that causes damage to the self‐constituents of body tissues by the products of the immune system. Graves’ hyperthyroidism occurs after the loss of tolerance to the thyroid stimulating hormone receptor (TSHR) and the generation of thyroid stimulatory antibodies that mimic the action of thyroid‐stimulating hormone (TSH).[1]
The Journal of Clinical Endocrinology and Metabolism | 2018
Yue Wang; Fengyi Zhao; Eddy Rijntjes; Liping Wu; Qian Wu; Jing Sui; Yufeng Liu; Meng Zhang; Mingqian He; Pu Chen; Shiqian Hu; Peng Hou; Lutz Schomburg; Bingyin Shi
Purpose To investigate the importance of dietary selenium (Se) for hyperthyroidism. Methods We performed a more in-depth analysis of a large cross-sectional study of 6152 participants from two counties within the Shaanxi Province, China. These counties are characterized by different habitual Se intake. We investigated the effects of a different dietary Se supply (0.02, 0.18, 0.6, or 2.0 ppm Se) on disease development in a mouse model of Graves disease (GD). Results The cross-sectional study revealed a comparable prevalence of hyperthyroidism, irrespective of Se intake, in both counties. However, an unexpected sex-specific difference was noted, and Se deficiency might constitute a risk factor for hyperthyroidism, especially in males. In a mouse model, pathological thyroid morphology was affected, and greater Se intake exerted some protecting effects on the pathological distortion. Circulating thyroid hormone levels, malondialdehyde concentrations, total antioxidant capacity, and the titer of GD-causing TSH receptor autoantibodies were not affected by Se. Expression analysis of the transcripts in the spleen indicated regulatory effects on genes implicated in the immune response, erythropoiesis, and oxygen status. However, the humoral immune response, including the CD4/CD8 or T-helper 1/T-helper 2 cell ratio and the concentration of regulatory T cells, was similar between the experimental groups, despite the difference in Se intake. Conclusions Our data have highlighted a sexual dimorphism for the interaction of Se and thyroid disease risk in humans, with indications of a local protective effects of Se on thyroid gland integrity, which appears not to be reflected in the circulating biomarkers tested.
Endocrinology | 2011
Liping Wu; Liru Xun; Jing Yang; Li Xu; Zhufang Tian; Shan Gao; Yu Zhang; Peng Hou; Bingyin Shi
Journal of Endocrinology | 2010
Feng Ye; Bingyin Shi; Xiaoyan Wu; Peng Hou; Lei Gao; Xiaodan Ma; Li Xu; Liping Wu
Journal of Endocrinology | 2013
Yue Wang; Liping Wu; Jiao Fu; Hongjun Lv; Xiaoyan Guan; Li Xu; Pu Chen; Chuqi Gao; Peng Hou; Meiju Ji; Bingyin Shi
Autoimmunity | 2012
Feng Ye; Peng Hou; Xiaoyan Wu; Xiaodan Ma; Lei Gao; Liping Wu; Li Xu; Bingyin Shi
Thyroid | 2016
Lianye Liu; Liping Wu; Aibo Gao; Qi Zhang; Hongjun Lv; Li Xu; Chuanqing Xie; Qian Wu; Peng Hou; Bingyin Shi
Chinese Medical Journal | 1985
Sun Cf; Wang Yl; Li Xu; Liping Wu
Advanced Science Letters | 2012
Xiaoyan Wu; Feng Ye; Liping Wu; Bingyin Shi; Xiaodan Ma; Lei Gao; Li Xu; Peng Hou
Archive | 2010
Bingyin Shi; Zhufang Tian; Qi Yang; Liping Wu; Li Xu; Lei Gao