Lloyd F. Craver

Jaundice in Hodgkin's disease

Abstract The pertinent literature dealing with jaundice in Hodgkins disease is reviewed, and an analysis is made of a series of 116 cases of jaundiced patients with Hodgkins disease observed at the Memorial Center. The pertinent pathologic findings in fifty-seven patients who came to autopsy also are presented. Evaluation of the cause of jaundice in Hodgkins disease often is difficult. The chief cause of jaundice in our autopsy series was, in order of frequency, liver involvement with Hodgkins disease (70.2 per cent), no satisfactory pathologic or clinical explanation of jaundice (14 per cent), hemolytic anemia (5.2 per cent), extrahepatic bile duct obstruction due to tumor (3.5 per cent), hepatitis (3.5 per cent), choledocholithiasis (1.8 per cent), cirrhosis (1.8 per cent). The conventional liver function tests were not very helpful in establishing the cause of jaundice. Liver biopsy, whenever feasible and not contraindicated by the danger of hemorrhage, should be used more extensively in order to establish the cause of jaundice. Some therapeutic considerations in the jaundiced patient with Hodgkins disease are discussed.

The liver in Hodgkin's disease

This is a survey of the incidence, morphology, and significance of hepatic changes in Hodgkins disease

LYMPHOSARCOMA: THE EFFECTS OF THERAPY AND SURVIVAL IN 1,269 PATIENTS IN A REVIEW OF 30 YEARS' EXPERIENCE

Excerpt INTRODUCTION A review has been completed of the experience with lymphosarcoma at the Memorial Center for Cancer and Allied Diseases during the last 30 years. This has been a comprehensive s...

The clinical use of chlorambucil: a critical study.

CHLORAMBUCIL (P-[di-2-chloroethylamino]-phenylbutyric acid, or CB 1348) is an analogue of nitrogen mustard that may be administered orally. There have been several reports attesting to its usefulne...

DETERMINATION OF C-REACTIVE PROTEIN IN THE BLOOD OF PATIENTS WITH HODGKIN'S DISEASE

Excerpt Since the first description of C-reactive protein by Tillett and Francis in 1930, the occurrence of this substance, which is not present in the blood of normal individuals, has been noted b...

Esophageal varices in Hodgkin's disease involving the liver

Abstract Two cases of Hodgkins disease with esophageal varices are reported. Both patients had extensive liver involvement with Hodgkins disease, and the second patient had, in addition, constrictive pericarditis. To the best of our knowledge, no cases of esophageal varices in patients with Hodgkins disease involving the liver have been reported. The occurrence of varices in cancers of the liver and other pathological conditions is discussed.