Loredana Barbu

Reaction of 4-hydroxycoumarin or its O-substituted derivatives with diatomic interhalogens: ICl and IBr

ABSTRACT Herein, we present some aspects regarding the iodination/bromination of 4-hydroxycoumarin or its O-methyl or O-acetyl derivatives with iodine monochloride or iodine monobromide as halogenation reagents. Also, the investigation of photochemical transformation of the three 3-iodocoumarins was investigated for the first time. GRAPHICAL ABSTRACT

A NOVEL APPROACH FOR THE SYNTHESIS OF PYRROLO(1,2-b)PYRIDAZINE DERIVATIVES

The reaction of N-phenacylpyridazinium bromides 3 and 7 with acrylonitrile as activated olefinic dipolarophile gave in the presence of triethylamine and the oxidant tertrakis-pyridinecobalt(II) dichromate (TPCD) in DMF at 90 oC pyrrolo[1,2-b]pyridazine derivatives 6 and 8. Structural proof for the compounds was provided by elemental analysis and NMR spectroscopy, including COSY and HETCOR experiments.