Lou S. Kan
Johns Hopkins University
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Featured researches published by Lou S. Kan.
Biochemical and Biophysical Research Communications | 1974
Lou S. Kan; Paul O. P. Ts'o; Friedrich von der Haar; Mathias Sprinzl; Friedrich Cramer
Summary The proton resonances of 13 methyl groups and 4 methylene groups belonging to 12 modified bases in tRNAyeastPhe were investigated by 220 MHz NMR spectrometry. The chemical shifts and the linewidths at half height of these assigned resonances in tRNA were measured as a function of temperature from 21° to 80°C. The results indicate: (1) The anticodon loop does not associate with other components of the molecule and the side chain of the Y base protrudes out into the solvent; (2) The methyl groups m5C40,49, m2G10, and m1A58 are not near any diamagnetic regions in the native tRNA; (3) The methyl and methylene groups in m22G, T, and hU are magnetically shielded and immobilized to a great extent in the native conformation, implying that these bases are deeply involved in the tertiary structure of tRNA.
Biochemistry | 1975
Philip N. Borer; Lou S. Kan; Paul O. P. Ts'o
Biochemistry | 1980
Lou S. Kan; Doris M. Cheng; Paul S. Miller; Junichi Yano; Paul O. P. Ts'o
Biochemistry | 1975
Lou S. Kan; Philip N. Borer; Paul O. P. Ts'o
Biochemistry | 1977
Lou S. Kan; Paul O. P. Ts'o; Mathias Sprinzl; F. Van der Haar; Friedrich Cramer
Biopolymers | 1973
Lou S. Kan; J. C. Barrett; Paul S. Miller; Paul O. P. Ts'o
Biopolymers | 1973
Lou S. Kan; J. C. Barrett; Paul O. P. Ts'o
Nucleic Acids Research | 1977
Lou S. Kan; Paul O. P. Ts'o
ChemInform | 1980
Doris M. Cheng; Lou S. Kan; Paul O. P. Ts'o; Claude Giessner-Prettre; Bernard Pullman
Biochemistry | 1981
Seiichi Uesugi; Yoko Takatsuka; Morio Ikehara; Doris M. Cheng; Lou S. Kan; Paul O. P. Ts'o
