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Publication
Featured researches published by Louis Brogley.
Bioorganic & Medicinal Chemistry Letters | 2010
Roy K. Hom; Simeon Bowers; Jennifer Sealy; Anh P. Truong; Gary D. Probst; Martin L. Neitzel; R. Jeffrey Neitz; Larry Fang; Louis Brogley; Jing Wu; Andrei W. Konradi; Hing L. Sham; Gergely Toth; Hu Pan; Nanhua Yao; Dean R. Artis; Kevin P. Quinn; John-Michael Sauer; Kyle Powell; Zhao Ren; Frederique Bard; Ted Yednock; Irene Griswold-Prenner
From high throughput screening, we discovered compound 1, the prototype for a series of disubstituted thiophene inhibitors of JNK which is selective towards closely related MAP kinases p38 and Erk2. Herein we describe the evolution of these compounds to a novel class of thiophene and thiazole JNK inhibitors that retain favorable solubility, permeability, and P-gp properties for development as CNS agents for treatment of neurodegeneration. Compound 61 demonstrated JNK3 IC(50)=77 nM and retained the excellent broad kinase selectivity observed for the series.
Journal of Medicinal Chemistry | 2007
Michel Maillard; Roy K. Hom; Timothy E. Benson; Joseph B. Moon; Shumeye S. Mamo; Michael J. Bienkowski; Alfredo G. Tomasselli; D. Danielle Woods; D. Bryan Prince; Donna J. Paddock; Thomas L. Emmons; John A. Tucker; Michael S. Dappen; Louis Brogley; Eugene D. Thorsett; Nancy Jewett; and Sukanto Sinha; Varghese John
Bioorganic & Medicinal Chemistry Letters | 2009
Jennifer Sealy; Anh P. Truong; L Tso; Gary D. Probst; Jose Aquino; Roy K. Hom; Barbara Jagodzinska; Darren B. Dressen; David W. G. Wone; Louis Brogley; John; Jay S. Tung; Michael A. Pleiss; John A. Tucker; Andrei W. Konradi; Michael S. Dappen; Gergley Tóth; Hu Pan; Lany Ruslim; J Miller; Michael P. Bova; Sukanto Sinha; Kevin P. Quinn; John-Michael Sauer
Bioorganic & Medicinal Chemistry Letters | 2010
Anh P. Truong; Gary D. Probst; Jose Aquino; Larry Fang; Louis Brogley; Jennifer Sealy; Roy K. Hom; John A. Tucker; Varghese John; Jay S. Tung; Michael A. Pleiss; Andrei W. Konradi; Hing L. Sham; Michael S. Dappen; Gergley Tóth; Nanhua Yao; Eric Brecht; Hu Pan; Dean R. Artis; Lany Ruslim; Michael P. Bova; Sukanto Sinha; Ted Yednock; Wes Zmolek; Kevin P. Quinn; John-Michael Sauer
Archive | 2005
Varghese John; Michel Maillard; Lawrence Fang; John A. Tucker; Louis Brogley; Jose Aquino; Simeon Bowers; Gary D. Probst; Jay S. Tung
Archive | 2005
Varghese John; Michel Maillard; John A. Tucker; Jose Aquino; Barbara Jagodzinska; Louis Brogley; Jay S. Tung; Simeon Bowers; Darren B. Dressen; Gary D. Probst; Neerav Shah
Archive | 2003
Francine S. Grant; Sarah Bartulis; Louis Brogley; Michael S. Dappen; Ramesh Kasar; Mohammed A. Khan; Martin L. Neitzel; Michael A. Pleiss; Eugene D. Thorsett; John A. Tucker; Michael Ye; Jon E. Hawkinson
Archive | 2003
John A. Tucker; Brian A. Sherer; Ying Zi Xu; Louis Brogley; Shon R. Pulley; Jon S. Jacobs; James P. Beck; Varghese John
Bioorganic & Medicinal Chemistry Letters | 2013
Raymond Ng; Minghua Sun; Simeon Bowers; Roy K. Hom; Gary D. Probst; Varghese John; Lawrence Y. Fang; Michel Maillard; Andrea Gailunas; Louis Brogley; R. Jeffrey Neitz; Jay S. Tung; Michael A. Pleiss; Andrei W. Konradi; Hing L. Sham; Michael S. Dappen; Marc Adler; Nanhua Yao; Wes Zmolek; David Nakamura; Kevin P. Quinn; John-Michael Sauer; Michael P. Bova; Lany Ruslim; Dean R. Artis; Ted Yednock
Archive | 2003
Francine S. Grant; Sarah Bartulis; Louis Brogley; Michael S. Dappen; Ramesh Kasar; Ryan Holcomb; Michael A. Pleiss; Eugene D. Thorsett; Michael Ye; Jon E. Hawkinson
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