Louis Storace

A new asymmetric 1,4-addition method: application to the synthesis of the HIV non-nucleoside reverse transcriptase inhibitor DPC 961

Abstract The asymmetric synthesis of the HIV non-nucleoside reverse transcriptase inhibitor (NNRTI) DPC 961 is achieved in three steps with an overall yield of >55%. The asymmetry is induced by the chiral auxiliary (R)-(+)-α-methylbenzylamine, utilizing a new asymmetric 1,4-addition protocol.

The chiral specific synthesis of DMP 754, a platelet GP IIbIIIa antagonist

Abstract An effective and chiral specific synthesis of DMP 754 ( 1 ), a non-peptide platelet GP IIb IIIa antagonist, is reported.