Loukianos Spyrou

Combined EEG-fNIRS Decoding of Motor Attempt and Imagery for Brain Switch Control: An Offline Study in Patients With Tetraplegia

Combining electrophysiological and hemodynamic features is a novel approach for improving current performance of brain switches based on sensorimotor rhythms (SMR). This study was conducted with a dual purpose: to test the feasibility of using a combined electroencephalogram/functional near-infrared spectroscopy (EEG-fNIRS) SMR-based brain switch in patients with tetraplegia, and to examine the performance difference between motor imagery and motor attempt for this user group. A general improvement was found when using both EEG and fNIRS features for classification as compared to using the single-modality EEG classifier, with average classification rates of 79% for attempted movement and 70% for imagined movement. For the control group, rates of 87% and 79% were obtained, respectively, where the “attempted movement” condition was replaced with “actual movement.” A combined EEG-fNIRS system might be especially beneficial for users who lack sufficient control of current EEG-based brain switches. The average classification performance in the patient group for attempted movement was significantly higher than for imagined movement using the EEG-only as well as the combined classifier, arguing for the case of a paradigm shift in current brain switch research.

Source Localization of Event-Related Potentials Incorporating Spatial Notch Filters

A novel algorithm for the localization of event-related potential (ERP) sources within the brain is proposed here. In this technique, spatial notch filters are developed to exploit the multichannel electroencephalogram data together with a model of ERP with variable parameters in order to accurately localize the corresponding ERP signal sources. The algorithm is robust in the presence of reasonably high noise. The performance of the proposed system has been compared to that of linear constrained minimum variance (LCMV) beamformer for different noise and correlation levels and its superiority has been demonstrated.

Separation and localisation of P300 sources and their subcomponents using constrained blind source separation

Separation and localisation of P300 sources and their constituent subcomponents for both visual and audio stimulations is investigated in this paper. An effective constrained blind source separation (CBSS) algorithm is developed for this purpose. The algorithm is an extension of the Infomax BSS system for which a measure of distance between a carefully measured P300 and the estimated sources is used as a constraint. During separation, the proposed CBSS method attempts to extract the corresponding P300 signals. The locations of the corresponding sources are then estimated with some indeterminancy in the results. It can be seen that the locations of the sources change for a schizophrenic patient. The experimental results verify the statistical significance of the method and its potential application in the diagnosis and monitoring of schizophrenia.

Deep learning for epileptic intracranial EEG data

Detection algorithms for electroencephalography (EEG) data typically employ handcrafted features that take advantage of the signals specific properties. In the field of interictal epileptic discharge (IED) detection, the feature representation that provides optimal classification performance is still an unresolved issue. In this paper, we consider deep learning for automatic feature generation from epileptic intracranial EEG data in the time domain. Specifically, we consider convolutional neural networks (CNNs) in a subject independent fashion and demonstrate that meaningful features, representing IEDs are automatically learned. The resulting model achieves state of the art classification performance, provides insights for the different types of IEDs within the group, and is invariant to time differences between the IEDs. This study suggests that automatic feature generation via deep learning is suitable for IEDs and EEG in general.

Detection of Intracranial Signatures of Interictal Epileptiform Discharges from Concurrent Scalp EEG

Interictal epileptiform discharges (IEDs) are transient neural electrical activities that occur in the brain of patients with epilepsy. A problem with the inspection of IEDs from the scalp electroencephalogram (sEEG) is that for a subset of epileptic patients, there are no visually discernible IEDs on the scalp, rendering the above procedures ineffective, both for detection purposes and algorithm evaluation. On the other hand, intracranially placed electrodes yield a much higher incidence of visible IEDs as compared to concurrent scalp electrodes. In this work, we utilize concurrent scalp and intracranial EEG (iEEG) from a group of temporal lobe epilepsy (TLE) patients with low number of scalp-visible IEDs. The aim is to determine whether by considering the timing information of the IEDs from iEEG, the resulting concurrent sEEG contains enough information for the IEDs to be reliably distinguished from non-IED segments. We develop an automatic detection algorithm which is tested in a leave-subject-out fashion, where each test subjects detection algorithm is based on the other patients data. The algorithm obtained a [Formula: see text] accuracy in recognizing scalp IED from non-IED segments with [Formula: see text] accuracy when trained and tested on the same subject. Also, it was able to identify nonscalp-visible IED events for most patients with a low number of false positive detections. Our results represent a proof of concept that IED information for TLE patients is contained in scalp EEG even if they are not visually identifiable and also that between subject differences in the IED topology and shape are small enough such that a generic algorithm can be used.

A Robust Constrained Method for the Extraction of P300 Subcomponents

Separation of event related potentials (ERPs) is being investigated in this paper by means of a new constrained blind source extraction (BSE) technique. Specifically, the P3a and P3b subcomponents are extracted from an ERP incorporating some prior knowledge of the desired signals. The method reliably extracts the desired P300 subcomponents with great accuracy. One advantage of BSE algorithms over blind signal separation (BSS), which have been used in EEG research, is that the algorithm focuses on one source instead of trying to extract all of the sources simultaneously which involves indeterminacy in the number of sources. To testify the performance of the algorithm, some experiments are shown which are performed on real EEG data

A regularised EEG informed Kalman filtering algorithm

Abstract The conventional Kalman filter assumes a constant process noise covariance according to the systems dynamics. However, in practice, the dynamics might alter and the initial model for the process noise may not be adequate to adapt to abrupt dynamics of the system. In this paper, we provide a novel informed Kalman filter (IKF) which is informed by an extrinsic data channel carrying information about the systems future state. Thus, each state can be represented with a corresponding process noise covariance, i.e. the Kalman gain is automatically adjusted according to the detected state. As a real-world application, we demonstrate for the first time how the analysis of electroencephalogram (EEG) can be used to predict the voluntary body movement and inform the tracking Kalman algorithm about a possible state transition. Furthermore, we provide a rigorous analysis to establish a relationship between the Kalman performance and the detection accuracy. Simulations on both synthetic and real-world data support our analysis.

Multiview classification of brain data through tensor factorisation

Brain signals arise as a mixture of various neural processes that occur in different spatial, frequency and temporal locations. In detection paradigms, algorithms are developed that target specific processes. In this work, we apply tensor factorisation to a set of intracranial electroencephalography data from a group of epileptic patients and factorise the data into three modes; space, time and frequency with each mode containing a number of components or signatures that are common between the subjects. We train separate classifiers on various feature sets corresponding to complementary combinations of those modes and components. These classifiers are then combined in a leave-subject-out fashion and subsequently used to estimate the classification accuracy of each combination on left-out subjects data. The relative influence on the classification accuracy of the respective spatial, temporal or frequency signatures can then be analysed and useful interpretations can be made.

Detection of attempted movement from the EEG during neuromuscular block: proof of principle study in awake volunteers

Brain-Computer Interfaces (BCIs) have the potential to detect intraoperative awareness during general anaesthesia. Traditionally, BCI research is aimed at establishing or improving communication and control for patients with permanent paralysis. Patients experiencing intraoperative awareness also lack the means to communicate after administration of a neuromuscular blocker, but may attempt to move. This study evaluates the principle of detecting attempted movements from the electroencephalogram (EEG) during local temporary neuromuscular blockade. EEG was obtained from four healthy volunteers making 3-second hand movements, both before and after local administration of rocuronium in one isolated forearm. Using offline classification analysis we investigated whether the attempted movements the participants made during paralysis could be distinguished from the periods when they did not move or attempt to move. Attempted movement trials were correctly identified in 81 (68–94)% (mean (95% CI)) and 84 (74–93)% of the cases using 30 and 9 EEG channels, respectively. Similar accuracies were obtained when training the classifier on the participants’ actual movements. These results provide proof of the principle that a BCI can detect movement attempts during neuromuscular blockade. Based on this, in the future a BCI may serve as a communication channel between a patient under general anaesthesia and the anaesthesiologist.

Decoding of single-trial auditory mismatch responses for online perceptual monitoring and neurofeedback

Multivariate pattern classification methods are increasingly applied to neuroimaging data in the context of both fundamental research and in brain-computer interfacing approaches. Such methods provide a framework for interpreting measurements made at the single-trial level with respect to a set of two or more distinct mental states. Here, we define an approach in which the output of a binary classifier trained on data from an auditory mismatch paradigm can be used for online tracking of perception and as a neurofeedback signal. The auditory mismatch paradigm is known to induce distinct perceptual states related to the presentation of high- and low-probability stimuli, which are reflected in event-related potential (ERP) components such as the mismatch negativity (MMN). The first part of this paper illustrates how pattern classification methods can be applied to data collected in an MMN paradigm, including discussion of the optimization of preprocessing steps, the interpretation of features and how the performance of these methods generalizes across individual participants and measurement sessions. We then go on to show that the output of these decoding methods can be used in online settings as a continuous index of single-trial brain activation underlying perceptual discrimination. We conclude by discussing several potential domains of application, including neurofeedback, cognitive monitoring and passive brain-computer interfaces.