Lucas U. R. Chiavelli
Universidade Estadual de Maringá
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Publication
Featured researches published by Lucas U. R. Chiavelli.
Journal of the Brazilian Chemical Society | 2014
Ana Beatriz Zanqui; Damila Rodrigues de Morais; Claudia Marques da Silva; Jandyson M. Santos; Lucas U. R. Chiavelli; Paulo Rodrigo Stival Bittencourt; Marcos N. Eberlin; Jesuí Vergílio Visentainer; Lúcio Cardozo-Filho; Makoto Matsushita
This study evaluated the Chia (Salvia hispanica L.) oil composition in terms of fatty acids (FA), sterols, acylglycerols and oxidative stability obtained via subcritical n-propane fluid extraction (SubFE-propane), in different temperatures and pressure conditions, as compared to Bligh & Dyer (BD), Soxhlet (SE) and Folch (FLS) extractions. Total lipid varied from 23.25 to 30.21% and the best yield was obtained by both SubFE-propane extraction at 45 oC and 12 MPa (A). α-Linolenic acid (18:3n-3) was the most abundant FA and SubFE-propane extraction provided the best results for the sum of n-3 and PUFA. All oil samples were similar in regard to triacylglycerols (TAG) profiles as measured via direct electrospray ionization mass spectrometry (ESI-MS) analysis. The total amounts of stigmasterol, β-tocopherol and tocopherol total were highest in the Chia oil obtained by BD, campesterol and sitosterol by SE and γ-tocopherol by SubFE-propane extraction. The SubFE-propane oil also presented the best (2 to 5 times) oxidation stability. SubFE-propane was the most efficient extraction method for Chia oil, providing the highest extraction yields, purity, oxidation stability and diverse profile of sterols.
Journal of the Brazilian Chemical Society | 2014
Elizangela Ambrosio; Lorena M. Milano; Maísa Tatiane Ferreira de Souza; Lucas U. R. Chiavelli; Paula Fernandes Montanher; Jesuí Vergílio Visentainer; Vitor C. Almeida; Nilson Evelázio de Souza; Juliana Carla Garcia
This study reports on the photodegradation of biodiesel in contact with water using the photo-Fenton reaction. After 360 h of photodegradation, we observed a reduction of 73% in the amount of fatty acid methyl esters (FAMEs) initially quantified by gas chromatography coupled with a flame ionization detector (GC/FID). During the photodegradation, peaks for ketones and epoxy groups in carbon chains were recorded by gas chromatography coupled with mass spectrometry (GC/MS), and typical aldehyde and short-chain fatty acid shifts in hydrogen nuclear magnetic resonance spectroscopy (1H NMR) were observed. Ecotoxicity assays with Artemia salina revealed the presence of toxic components in the aqueous phase in increasing amounts up to 168 h of photodegradation and decreasing thereafter.
Journal of the Brazilian Chemical Society | 2014
Swami A. Maruyama; Thiago Claus; Lucas U. R. Chiavelli; Janksyn Bertozzi; Eduardo Jorge Pilau; Nilson Evelázio de Souza; Jesuí Vergílio Visentainer; Sandra Terezinha Marques Gomes; Makoto Matsushita
Each food matrix is unique. Thus, the endogenous antioxidants of an underexplored bakery product might show different responses regarding free radical scavenging/resistance to forced oxidation than what is expected for other foods previously reported in the literature. In this context, a Box-Behnken design and correlation studies were applied in order to obtain more information about how specific antioxidants affect the total antioxidant activity (TAC) and the degree of forced oxidation in white breads with chia seeds and carrot leaves. Hypotheses of synergism/antagonism between the studied compounds were also elucidated in order to justify the obtained results. In this specific sample type, carotenoids and cholesterol showed the greatest relationships with results from TAC assays, as well with induction points using Oxitest® equipment, while α-tocopherol and phytosterols showed negative correlations. Phenolic compounds did not have any influence on the system because the baking procedure at high temperature had severe impacts on them.
Journal of Natural Products | 2016
Vanessa G. A. Olher; Nagela P. Ferreira; Alan G. Souza; Lucas U. R. Chiavelli; Aline F. Teixeira; Wanderley D. Santos; Silvana Maria de Oliveira Santin; Osvaldo Ferrarese Filho; Cleuza C. da Silva; Armando M. Pomini
Acyl-homoserine lactones (AHLs) are a class of compounds produced by Gram-negative bacteria that are used in a process of chemical communication called quorum sensing. Much is known about how bacteria use these chemical compounds to control the expression of important factors; however, there have been few reports about the presence and effects of AHLs in plants. In this study, the phytochemical study of leaves and culms of sugar cane (Saccharum × officinarum) led to the identification of N-(3-oxo-octanoyl)homoserine lactone. Since the absolute configuration of the natural product could not be determined, both R and S enantiomers of N-(3-oxo-octanoyl)homoserine lactone were synthesized and tested in sugar cane culms. The enantiomers caused changes in the mass and length of buds and roots when used at micromolar concentrations. Using the sugar cane RB96-6928 variety, the S enantiomer increased sprouting of roots more effectively than the R enantiomer. Furthermore, scanning electron microscopy showed that both the R and S enantiomers led to more stretched root cells compared with the control.
Analytical Letters | 2013
Luana de Figueiredo; Lucas U. R. Chiavelli; Willian da Costa
In this work, a method to determine the concentration levels of organochlorine pesticides in water samples from the Mandacaru stream in the region of Maringá- Paraná was validated, using the technique of solid phase extraction associated with gas chromatography coupled to mass spectrometry. In the optimization of the method, parameters such as injector temperature and splitless time were evaluated. The analytical curves showed linear correlation values greater than 0.99 (R2 > 0.99) for all compounds. The detection limits of 0.243 µg L−1 to 1.200 µg L−1 and quantification of 5.0 µg L−1 were obtained for pesticides and the recovery values were between 88.25 and 127.3%. Values of relative standard deviation were less than 6.79%. In the water samples analyzed were found four organochlorine pesticides, two with concentrations within the limits set by national legislation and two with concentrations above these limits.
Anais Da Academia Brasileira De Ciencias | 2016
Vanessa G. Alves; Alan G. Souza; Lucas U. R. Chiavelli; João Ernesto de Carvalho; Armando M. Pomini; Cleuza C. da Silva
The cultivation of sugarcane hybrids (X Saccharum officinarum L.) is an important revenue source for the Brazilian economy. Herein it is reported the evaluation of the cytotoxic activity of mid-polarity sugarcane extracts against human cancer cell lines, as well as the isolation of steroids sitosterol, stigmasterol and campesterol, phenolic acids p-hydroxybenzoic, p-hydroxycinnamic, vanillic and ferulic acid, terpenoids α-tocopherol and β-carotene and a novel substance in sugarcane, the flavonoid aglycone tricin (5,7,4-trihydroxy-3,5-dimethoxyflavone). The presence of large amounts of phenolic acids and the flavonoid tricin may explain the cytostatic activity observed for the mid-polarity crude extract and filtrates.
Química Nova | 2014
Thiago L. de Almeida; Josiane A. Monteiro; Greice K. P. Lopes; Lucas U. R. Chiavelli; Silvana Maria de Oliveira Santin; Cleuza C. da Silva; Vanessa Kaplum; Débora B. Scariot; Celso Vataru Nakamura; João Ernesto de Carvalho; Ricardo Tadeu de Faria; Armando M. Pomini
The chemical study of the orchid Maxillaria picta resulted in the isolation of the bioactive stilbenes phoyunbene B and phoyunbene C, in addition to four phenolic acids, one xanthone, steroidal compounds and two triterpenes. Crude extract, fractions, subfractions and the isolated xanthone were evaluated for anticancer activity against human tumor cell lines and against evolutionary forms of T. cruzi and L. amazonensis. The structures of the compounds were determined by GC-MS, and 1H NMR, 13C NMR spectral methods as well as bidimensional techniques.
Journal of Essential Oil Bearing Plants | 2014
Jeovandro Maria Beltrame; Ricardo Almir Angnes; Lucas U. R. Chiavelli; Willian Ferreira da Costa; Silvana F. Montanher; Mauricio Ferreira da Rosa; Viviane da Silva Lobo; Armando M. Pomini
Abstract A comparative study of the chemical composition of essential oils of basil (Ocimum basilicum L.) grown in different localities in southern Brazil was conducted. This plant is seen as a promising source of linalool, a substance widely used in cosmetics and fragrances. The main objective of this study was to determine whether the procedures of drying plant and geographic origin of material plant (municipalities of Toledo (PR) and Jardinópolis (SC), south Brazil) provide significant changes in the chemical composition of essential oil. As a result, there were no significant differences in chemical composition of the oil from different regions, while the drying procedure has profoundly altered the chemical profile of the oil. Plant drying under sun reduced the concentration of linalool in the essential oil. These results can support future projects of essential oil production in these regions, characterized by the presence of small farms with a high incidence of family labor, which may represent a new source of income with a product with high added value.
Natural Product Research | 2017
Andrezza Correia Belloto; Gredson Keiff Souza; Paula C. Perin; Ivania Teresinha Albrecht Schuquel; Silvana Maria de Oliveira Santin; Lucas U. R. Chiavelli; Francielle Pelegrin Garcia; Vanessa Kaplum; Jean Henrique da Silva Rodrigues; Débora B. Scariot; Rodrigo Delvecchio; Erik Machado-Ferreira; Renato S. Aguiar; Carlos A. G. Soares; Celso Vataru Nakamura; Armando M. Pomini
Abstract The phytochemical study of Laelia marginata (Lindl.) L. O. Williams (Orchidaceae) led to the isolation of a new natural product named crispoic acid (1), together with six other known compounds (2–7). The new natural product was identified as a dimer of eucomic acid and was structurally characterised based upon 1D and 2D NMR and HRMS data. Biological assays with plant crude extract, fractions and isolated compounds were performed against two human cancer cell lines (Hela and Siha), and the tropical parasites Trypanosoma cruzi and Leishmania (Leishmania) amazonensis. The phenantrenoid 9,10-dihydro-4-methoxyphenanthren-2,7-diol 2 was active against Hela and Siha cells (CC50 5.86 ± 0.19 and 20.78 ± 2.72 μg/mL, respectively). Sub-lethal concentrations of the flavone rhamnazin 4 were not able to rescue the viability of the Vero cells infected by Zika virus.
Journal of Supercritical Fluids | 2015
Claudia Marques da Silva; Ana Beatriz Zanqui; Aline Kirie Gohara; Aloisio Henrique Pereira de Souza; Lúcio Cardozo-Filho; Jesuí Vergílio Visentainer; Lucas U. R. Chiavelli; Paulo Rodrigo Stival Bittencourt; Edson Antonio da Silva; Makoto Matsushita