Lucero Noguera-Morel

Cutaneous Drug Reactions in the Pediatric Population

Cutaneous adverse drug reactions (ADRs) constitute a major pediatric health problem frequently encountered in clinical practice, and represent a diagnostic challenge. Children are more susceptible than adults to errors in drug dosage because of their smaller body size; moreover, ADRs can mimic other skin diseases of children, especially viral exanthems. Most ADRs with cutaneous involvement are mild and resolve on withdrawal of the causative drug. The most common forms of cutaneous ADRs, maculopapular exanthems and urticarial reactions, have excellent outcomes. Less frequent but more severe reactions may incur a risk of mortality.

Ivermectin therapy for papulopustular rosacea and periorificial dermatitis in children: A series of 15 cases

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Chronic urticaria in infants as the first manifestation of autoinflammatory disease

We report two unrelated infants in whom chronic urticaria was the first clinical manifestation of cryopyrin‐associated periodic syndrome, which should be suspected in infants with early‐onset chronic urticaria, especially if there is a neutrophil‐rich infiltrate in the skin biopsy. Early diagnosis of cryopyrin‐associated periodic syndrome may lead to early and successful treatment with anti‐interleukin‐1 medications.

Superimposed linear atopic dermatitis

Superimposed linear atopic dermatitis is rarely manifested in polygenic disease as a counterpart to type 2 segmental mosaicism of monogenic skin diseases. Linear arrangement following Blaschko lines represents more severe disease on a generalized background of atopic dermatitis, perhaps reflecting clonal loss of heterozygosity. Only three cases of superimposed linear atopic dermatitis have been reported; we describe three additional cases.

Omeprazole-induced hypertrichosis in two children

Omeprazole significantly increases duodenal prostaglandin E2 synthesis. Prostaglandins are involved in hair growth regulation: prostaglandin E2 and prostaglandin F2 alpha stimulate hair growth, and prostaglandin D2 has an inhibitory effect. The use of omeprazole can cause acquired generalized hypertrichosis by increasing prostaglandin E2 levels.

Methotrexate for severe nummular eczema in children: Efficacy and tolerability in a retrospective study of 28 patients

Nummular eczema in children is a chronic condition characterized by pruritic coin‐shaped eczematous lesions that affect any part of the body and often become exudative. Mid‐ to high‐potency topical corticosteroids are considered the mainstay treatment, but there are limited data on the use of systemic therapy for nummular eczema in children. The objective of the current study was to evaluate the efficacy and safety of methotrexate in children with severe nummular eczema.

Ultrasound findings in idiopathic facial aseptic granuloma: Case series and literature review

Idiopathic facial aseptic granuloma is an inflammatory nodule commonly located on the cheeks and eyelids in young children. Despite its prolonged course, it tends toward spontaneous resolution, so invasive diagnostic procedures should be avoided. Cutaneous ultrasound is a noninvasive modality that has been found to improve the diagnostic accuracy of nodular skin lesions. We report five children with idiopathic facial aseptic granuloma in whom high‐resolution ultrasound examination provided distinctive findings.

Identical COL71A1 heterozygous mutations resulting in different dystrophic epidermolysis bullosa phenotypes

Dystrophic epidermolysis bullosa is a rare blistering condition caused by mutations in the COL7A1 gene. Different clinical variants have been described, with dominant and recessive inheritance, but no consistent findings have been elucidated to establish a genotype–phenotype correlation. We present three unrelated patients with two identical pathogenic compound heterozygous mutations in the COL7A1 gene that developed different clinical forms of dystrophic epidermolysis bullosa—epidermolysis bullosa pruriginosa and mild recessive non‐Hallopeau–Siemens—raising the possibility of other genetic or environmental modifying factors responsible for the phenotype of the disease.

Cutaneous Leishmania tropica in children: report of three imported cases successfully treated with liposomal amphotericin B

Cutaneous leishmaniasis (CL) is the most common form of leishmaniasis, being endemic in more than 90 countries around the world. The increasing number of international travelers to endemic areas has favored the expanding number of imported cases, making CL a mayor health issue.1,2 Herein, we report three immunocompetent children with multifocal CL caused by Leishmania tropica who received systemic therapy with liposomal amphotericin B (L-AmB). n nThis article is protected by copyright. All rights reserved.

Pityriasis rubra pilaris-like eruption with dermatomyositis and diffuse cutaneous systemic sclerosis overlap.

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