Lucidio Cristovão Fardelone

Chiral Pharmaceutical Intermediaries Obtained by Reduction of 2-Halo-1-(4-substituted phenyl)-ethanones Mediated by Geotrichum candidum CCT 1205 and Rhodotorula glutinis CCT 2182

Enantioselective reductions of p-R1-C6H4C(O)CH2R2 (R1 = Cl, Br, CH3, OCH3, NO2 and R2 = Br, Cl) mediated by Geotrichum candidum CCT 1205 and Rhodotorula glutinis CCT 2182 afforded the corresponding halohydrins with complementary R and S configurations, respectively, in excellent yield and enantiomeric excesses. The obtained (R)- or (S)-halohydrins are important building blocks in chemical and pharmaceutical industries.

Synthesis of alpha-aminoalkylphosphonates mediated acetic acid

Alpha-amino-alkylphosphonates 4a-e were synthesized using aldehydes, benzyl carbamate and trimethylphosphite mediated acetic acid at reflux, in presence of anhydrous magnesium sulfate or 4Å molecular sieves. These methodology providing alpha-amino-alkylphosphonates 4a-e in moderated-good yields.

Enantioselective Hydrolysis of 1-Aryl-2-chloroethyl propanoate Mediated by Burkholderia cepacia and Candida rugosa Lipases.

Enantioselective hydrolysis of racemic compounds 4a-b by lipases from Burkholderia cepacia and Candida rugosa afforded the corresponding alcohols in 79-91%, isolated yield, that can be used as building blocks for stereoselective syntheses of pharmaceuticals compounds as Sotalol and Sertraline.