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Dive into the research topics where Ludger Dinkelborg is active.

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Featured researches published by Ludger Dinkelborg.


Archive | 2017

How to Identify Suitable Molecular Imaging Biomarkers

Norman Koglin; Andre Mueller; Andrew Stephens; Ludger Dinkelborg

Molecular imaging biomarkers offer the unique possibility for earlier disease detection and better characterisation, as well as enabling of drug development. Addressing a relevant biomedical question, selecting the right target and the optimisation of ligand binding as well as pharmacokinetic parameters in preclinical models are the crucial steps before a suitable imaging agent can enter the clinical evaluation. General concepts for the selection of a suitable molecular imaging biomarker and preclinical aspects for target and ligand evaluation are presented and illustrated with examples. The clinical development of new imaging agents is discussed in light of the recently approved beta-amyloid plaque imaging agents and the diagnostic need in Alzheimer’s disease.


Nucleic Acids Research | 2004

Application of locked nucleic acids to improve aptamer in vivo stability and targeting function

Kathrin Schmidt; Sandra Borkowski; Jens Kurreck; Andrew Stephens; Rolf Bald; Maren Hecht; Matthias Friebe; Ludger Dinkelborg; Volker A. Erdmann


Archive | 2007

[f-18]-labeled l-glutamic acid, [f-18]-labeled l-glutamine, their derivatives and their use and processes for their preparation

Ludger Dinkelborg; Matthias Friebe; Raisa Nikolaevna Krasikowa; Yuri N. Belokon; O. F. Kuznetsova; Keith Graham; Lutz Lehmann; Mathias Berndt; Heribert Schmitt-Willich


Archive | 2006

[18F] labelled L-glutamic acid, [18F] labelled glutamine, their derivatives, their use and processes for their preparation

Ludger Dinkelborg; Matthias Friebe; Raisa Nikolaevna Krasikowa; Yuri N. Belokon; O. F. Kuznetsova; Keith Graham; Lutz Lehmann; Mathias Berndt


Society of Nuclear Medicine Annual Meeting Abstracts | 2012

Preclinical validation of the Ga-68-bombesin antagonist BAY 86-7548 for a phase I study in prostate cancer patients

Sandra Borkowski; Olaf Doehr; Christina Hultsch; Peter Weinig; Bernd Elger; Christa Hegele-Hartung; Keith Graham; Ludger Dinkelborg


Archive | 2009

Radiation Dosimetry of b-Amyloid Tracers 11 C-PiB and 18 F-BAY94-9172

Graeme O'Keefe; Timothy Saunder; Steven Ng; Uwe Ackerman; Henri Tochon-Danguy; J. Gordon Chan; Sylvia Gong; Thomas Dyrks; Stefanie Lindemann; Gerhard Holl; Ludger Dinkelborg; Victor Villemagne; Christopher Rowe


Society of Nuclear Medicine Annual Meeting Abstracts | 2007

First results from human studies of a novel F-18 PET ligand for brain {beta}-amyloid imaging

Christopher Rowe; Steven Ng; Rachel S. Mulligan; Uwe Ackermann; William Browne; Graeme O'Keefe; Henri Tochon-Danguy; Gordon Chan; Hank Kung; Mei-Ping Kung; Daniel Skovronsky; Thomas Dyrks; Gerhard Holl; Sabine Krause; Matthias Friebe; Stefanie Lindemann; Wolf Sittner; Ludger Dinkelborg; Colin Masters; Victor Villemagne


Society of Nuclear Medicine Annual Meeting Abstracts | 2010

[F-18]BAY 85-8050: A novel tumor specific probe for PET imaging - Preclinical results

Norman Koglin; Matthias Friebe; Mathias Berndt; Keith Graham; Raisa Krasikova; Olga Kuznetsova; Yuri N. Belokon; Lutz Lehmann; Linjing Mu; Ludger Dinkelborg


Society of Nuclear Medicine Annual Meeting Abstracts | 2009

In vivo PET tumour imaging using an [F-18] labelled aptamer targeting tenascin-C

Raphaël Boisgard; Bertrand Kuhnast; Benoit Jego; Karine Siquier; Françoise Hinnen; Frédéric Dollé; Matthias Friebe; Sandra Borkowski; Ludger Dinkelborg; Bertrand Tavitian


Society of Nuclear Medicine Annual Meeting Abstracts | 2009

Comparisons of animal-human translated and human 18F-BAY94-9172 amyloid radiation dosimetry

Graeme O'Keefe; Timothy Saunder; Sylvia Gong; Kunthi Pathmaraj; Henri Tochon-Danguy; Victor Villemagne; Sabine Krause; Thomas Dyrks; Ludger Dinkelborg; Christoper Rowe

Collaboration


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Matthias Friebe

Free University of Berlin

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Mathias Berndt

Bayer HealthCare Pharmaceuticals

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Lutz Lehmann

Bayer HealthCare Pharmaceuticals

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Yuri N. Belokon

A. N. Nesmeyanov Institute of Organoelement Compounds

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Thomas Dyrks

Bayer Schering Pharma AG

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O. F. Kuznetsova

Russian Academy of Sciences

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Graeme O'Keefe

Ludwig Institute for Cancer Research

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Victor Villemagne

Commonwealth Scientific and Industrial Research Organisation

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