Network


Latest external collaboration on country level. Dive into details by clicking on the dots.

Hotspot


Dive into the research topics where Luigi Rossetti is active.

Publication


Featured researches published by Luigi Rossetti.


Biophysical Chemistry | 2000

The main role of the sequence-dependent DNA elasticity in determining the free energy of nucleosome formation on telomeric DNAs.

Ilaria Filesi; Stefano Cacchione; Pasquale De Santis; Luigi Rossetti; Maria Savino

Using a competitive reconstitution assay, we measured the free energy spent in nucleosome formation of eight telomeric DNAs, differing in sequence and/or in length. The obtained values are in satisfactorily good agreement with those derived from a theoretical model that allows the calculation of the free energy of nucleosome formation on the basis of sequence-dependent DNA elasticity, using a statistical thermodynamic approach. Both theoretical and experimental evaluations show that telomeres are characterized by the highest free energies of nucleosome formation among all the DNA sequences so far studied. The free energy of nucleosome formation varies according to the different telomeric sequences and the length of the fragments. Theoretical analysis and experimental mapping by lambda exonuclease show that telomeric nucleosomes occupy multiple positions spaced every telomeric repeat. Sequence-dependent DNA elasticity appears as the main determinant of the stability of telomeric nucleosomes and their multiple translational positioning.


Biochimica et Biophysica Acta | 1997

DIFFERENT BINDINGS OF THE MINOR GROOVE LIGANDS DAPI AND HOECHST 33258 TO MULTIMERS OF THE CURVED (CA4T4G) AND NONCURVED (CT4A4G) DNA SEQUENCES

Roberto Caneva; Alessandro De Simoni; Luciano Mayol; Luigi Rossetti; Maria Savino

Equilibrium binding properties of DAPI and Hoechst for prototype curved (CA4T4G)n and straight (CT4A4G)n DNAs were derived from fluorescence intensity. Both decamers display a single strong binding site for each ligand. Hoechst binds seven times stronger to curved than to straight DNA. An additional cooperative, much weaker binding site is found for DAPI.


Biochimica et Biophysica Acta | 1996

DNA minor groove accessibility in the nucleosome core deduced from specific interactions with DAPI

Roberto Caneva; Luigi Rossetti; Maria Savino

Equilibrium binding properties of DAPI for purified nucleosome cores were derived from fluorescence intensity enhancement. Both the affinity and the number of sites of the primary, minor groove binding are preserved with respect to the corresponding isolated DNA, suggesting that the capacity for specific interactions of the minor groove may well be exerted in chromatin.


Bioorganic & Medicinal Chemistry Letters | 2006

Natural and synthetic G-quadruplex interactive berberine derivatives

Marco Franceschin; Luigi Rossetti; Anna D'Ambrosio; Stefano Schirripa; Armandodoriano Bianco; Giancarlo Ortaggi; Maria Savino; Christoph Schultes; Stephen Neidle


Bioorganic & Medicinal Chemistry Letters | 2002

Perylene diimides with different side chains are selective in inducing different G-quadruplex DNA structures and in inhibiting telomerase.

Luigi Rossetti; Marco Franceschin; Armandodoriano Bianco; Giancarlo Ortaggi; Maria Savino


Biochemistry | 1998

NUCLEOSOME ASSEMBLY ON TELOMERIC SEQUENCES

Luigi Rossetti; Stefano Cacchione; M. Fua; Maria Savino


Bioorganic & Medicinal Chemistry Letters | 2005

Selective interactions of perylene derivatives having different side chains with inter- and intramolecular G-quadruplex DNA structures. A correlation with telomerase inhibition

Luigi Rossetti; Marco Franceschin; Stefano Schirripa; Armandodoriano Bianco; Giancarlo Ortaggi; Maria Savino


Journal of Molecular Biology | 2001

Specific interactions of the telomeric protein Rap1p with nucleosomal binding sites.

Luigi Rossetti; Stefano Cacchione; Amanda De Menna; Lynda Chapman; Daniela Rhodes; Maria Savino


Journal of Molecular Biology | 2006

The human telomeric protein TRF1 specifically recognizes nucleosomal binding sites and alters nucleosome structure

Alessandra Galati; Luigi Rossetti; Sabrina Pisano; Lynda Chapman; Daniela Rhodes; Maria Savino; Stefano Cacchione


Biophysical Chemistry | 2007

A model for triple helix formation on human telomerase reverse transcriptase (hTERT) promoter and stabilization by specific interactions with the water soluble perylene derivative, DAPER.

Luigi Rossetti; Giuliana D'Isa; Clementina Mauriello; Michela Varra; Pasquale De Santis; Luciano Mayol; Maria Savino

Collaboration


Dive into the Luigi Rossetti's collaboration.

Top Co-Authors

Avatar

Maria Savino

Sapienza University of Rome

View shared research outputs
Top Co-Authors

Avatar

Stefano Cacchione

Sapienza University of Rome

View shared research outputs
Top Co-Authors

Avatar
Top Co-Authors

Avatar

Giancarlo Ortaggi

Sapienza University of Rome

View shared research outputs
Top Co-Authors

Avatar

Marco Franceschin

Sapienza University of Rome

View shared research outputs
Top Co-Authors

Avatar

Daniela Rhodes

Laboratory of Molecular Biology

View shared research outputs
Top Co-Authors

Avatar

Lynda Chapman

Laboratory of Molecular Biology

View shared research outputs
Top Co-Authors

Avatar

Amanda De Menna

Sapienza University of Rome

View shared research outputs
Top Co-Authors

Avatar

Luciano Mayol

University of Naples Federico II

View shared research outputs
Top Co-Authors

Avatar

Pasquale De Santis

Sapienza University of Rome

View shared research outputs
Researchain Logo
Decentralizing Knowledge