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Lulin Wei

Pfizer

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Publication

Featured researches published by Lulin Wei.

Journal of Organic Chemistry | 2010

Preparation and Utility of Trihaloethyl Imidates: Useful Reagents for the Synthesis of Amidines

Stephane Caron; Lulin Wei; Jasmin Douville; Arun Ghosh

2,2,2-Trifluoro- and trichloroethyl imidates, which are easily prepared by reaction of a nitrile and a trihaloethanol in the presence of HCl, have proven to be excellent reagents for the preparation of amidines under mild reaction conditions. Depending on the nature of the amine nucleophile, the imidates can react either as the free-base or the hydrochloride salt in a telescoped process. In several cases, the p-bromobenzoate salt of the desired product was directly isolated from the reaction mixture.

Organic Process Research & Development | 2005

Evaluation of kilogram-scale Sonagashira, Suzuki, and Heck coupling routes to oncology candidate CP-724,714

David H. Brown Ripin; Dennis E. Bourassa; Thomas A. Brandt; Michael J. Castaldi; Heather N. Frost; Joel M. Hawkins; Phillip J. Johnson; Stephen S. Massett; Karin Neumann; James Phillips; Jeffery W. Raggon; Peter Robert Rose; Jennifer L. Rutherford; Barbara J. Sitter; A. Morgan Stewart; Michael G. Vetelino; Lulin Wei

Organic Process Research & Development | 2004

Streamlined Processes for the Synthesis of a Farnesyl Transferase Inhibitor Drug Candidate

Brian M. Andresen; Michel Couturier; Brian Cronin; Michael D'Occhio; Marcus Ewing; Mark Guinn; Joel M. Hawkins; V. John Jasys; Susan D. LaGreca; Joseph P. Lyssikatos; Garrett Moraski; Karl Ng; Jeffrey W. Raggon; A. Morgan Stewart; Derek L. Tickner; John L. Tucker; Frank J. Urban; and Enrique Vazquez; Lulin Wei

Tetrahedron | 2009

Development of two synthetic routes to CE-178,253, a CB1 antagonist for the treatment of obesity

Thomas A. Brandt; Stephane Caron; David B. Damon; Joseph DiBrino; Arun Ghosh; David A. Griffith; Sandeep Kedia; John A. Ragan; Peter Robert Rose; Brian C. Vanderplas; Lulin Wei

Organic Process Research & Development | 2003

Synthesis and purification of 6-ethoxy-4-oxo-1,4-dihydro-[1,5]naphthyridine-3-carboxylic acid benzylamide

Justin Beaudin; Dennis E. Bourassa; Paul Bowles; Michael J. Castaldi; Ronald J. Clay; Michel Couturier; Gregory L. Karrick; Teresa W. Makowski; Ruth E. McDermott; Clifford N. Meltz; Morgan Meltz; James Phillips; John A. Ragan; David H. Brown Ripin; Robert A. Singer; John L. Tucker; Lulin Wei

Synthesis | 2012

Preparation of Substituted Benzimidazoles and Imidazopyridines Using 2,2,2-Trichloroethyl Imidates

Stephane Caron; Brian P. Jones; Lulin Wei

Organic Process Research & Development | 2012

Synthesis of an H3 Antagonist via Sequential One-Pot Additions of a Magnesium Ate Complex and an Amine to a 1,4-Ketoester followed by Carbonyl-Directed Fluoride Addition

Joel M. Hawkins; Pascal Dubé; Mark T. Maloney; Lulin Wei; Marcus Ewing; Stephen M. Chesnut; Joshua R. Denette; Brett M. Lillie; Rajappa Vaidyanathan

Tetrahedron-asymmetry | 2008

Efficient synthesis of (R)-3-amino-1,1,1-trifluoropropan-2-ol via a Dakin–West reaction followed by enantioselective reduction

Lulin Wei; Teresa W. Makowski; Carlos Alberto Martinez; Arun Ghosh

Organic Process Research & Development | 2005

Process Enabling and the Scale-Up of 6β-Hydroxymethylsulbactam and Its Esters

Timothy Norris; David H. Brown Ripin; Paul Ahlijanian; Brian M. Andresen; Mark T. Barrila; Roberto Colon-Cruz; Michel Couturier; Joel M. Hawkins; Ioulia V. Loubkina; Jennifer L. Rutherford; Kurt Stickley; Lulin Wei; Roel Vollinga; Robert de Pater; Peter Johannes Dominicus Maas; Ben de Lange; Dominique Monique Charles Callant; Jeroen Konings; Jean Andrien; Jos Versleijen; Jos Hulshof; Elena Daia; and Natalka Johnson; David W. L. Sung

Journal of Fluorine Chemistry | 2012

An efficient synthesis of 3,3-difluoro-pyrrolidine hydrochloride starting with 2-chloro-2,2-difluoroacetic acid

Lulin Wei; Teresa Margaret Makowski; Jennifer Lea Rutherford

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Collaboration

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John L. Tucker

Pfizer

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Joanna Teresa Negri

Pfizer

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Philip D. Hammen

Pfizer

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Joel M. Hawkins

Pfizer

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Stephane Caron

Pfizer

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Arun Ghosh

Pfizer

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David H. Brown Ripin

Pfizer

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Michel Couturier

Pfizer

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Brian M. Andresen

Pfizer

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Dennis E. Bourassa

Pfizer

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