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Dive into the research topics where Ly M. Nguyen is active.

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Featured researches published by Ly M. Nguyen.


Journal of Social Psychology | 1993

Depressive Symptoms Among Vietnamese-American College Students

Ly M. Nguyen; Christopher Peterson

Fifty Vietnamese-American college students completed questionnaires measuring depressive symptoms, stressful life events, and acculturation to Vietnamese society versus U.S. society. In contrast to the findings of earlier studies, in which attention was limited to depressive symptoms specific to traditional Vietnamese culture, no gains in reliability or validity were apparent when analyses were limited to these symptoms. Acculturation to U.S. society was positively associated with increased reports of depressive symptoms, as was the occurrence of stressful life events. Implications of these findings are discussed in terms of the changing nature of the Vietnamese-American population.


Cancer Treatment Reviews | 2010

Molecular biology of breast cancer stem cells: Potential clinical applications

Nam P. Nguyen; Fabio S. Almeida; Alex Chi; Ly M. Nguyen; Deirdre Cohen; Ulf Karlsson; Vincent Vinh-Hung

Breast cancer stem cells (CSC) have been postulated recently as responsible for failure of breast cancer treatment. The purpose of this study is to review breast CSCs molecular biology with respect to their mechanism of resistance to conventional therapy, and to develop treatment strategies that may improve survival of breast cancer patients. A literature search has identified in vitro and in vivo studies of breast CSCs. Breast CSCs overexpress breast cancer resistance protein (BCRP) which allows cancer cells to transport actively chemotherapy agents out of the cells. Radioresistance is modulated through activation of Wnt signaling pathway and overexpression of genes coding for glutathione. Lapatinib can selectively target HER-2 positive breast CSCs and improves disease-free survival in these patients. Metformin may target basal type breast CSCs. Parthenolide and oncolytic viruses are promising targeting agents for breast CSCs. Future clinical trials for breast cancer should include anti-cancer stem cells targeting agents in addition to conventional chemotherapy. Hypofractionation radiotherapy may be indicated for residual disease post chemotherapy.


QJM: An International Journal of Medicine | 2010

Human papillomavirus-associated oropharyngeal cancer: a new clinical entity

N.P. Nguyen; A. Chi; Ly M. Nguyen; B.H. Ly; U. Karlsson; Vincent Vinh-Hung

The incidence of oropharyngeal cancers is rising worldwide in both nonsmokers and nondrinkers. Epidemiology studies suggest a strong association between human papillomavirus (HPV) 16 infection, changing sexual behavior and cancer development. Despite initial presentation with locally advanced disease and poorly differentiated histology, HPV-associated oropharyngeal carcinoma is associated with a good prognosis because its response to chemotherapy and radiation. Clinicians should be aware of the risk of oropharyngeal cancer in young people to avoid unnecessary delay in diagnosis and treatment. A history of oral sex should be elicited in young patients with enlarged neck nodes and/or tonsillar masses.


British Journal of Radiology | 2009

Analysis of factors influencing aspiration risk following chemoradiation for oropharyngeal cancer

Nam P. Nguyen; C. Frank; C. C. Moltz; Paul Vos; Herbert J. Smith; P D Nguyen; T. Martinez; Ulf Karlsson; Suresh Dutta; C Lemanski; Ly M. Nguyen; Sabah Sallah

Our aim was to identify risk factors for aspiration following concurrent chemoradiation for oropharyngeal cancer. 46 patients with locally advanced oropharyngeal carcinoma underwent concurrent chemoradiation at our institution. All patients underwent modified barium swallow to assess dysphagia severity and to determine the need for continued tube feedings after treatment. Dysphagia severity was graded as 1-7. There were 5 Grade 2, 11 Grade 3, 5 Grade 4, 5 Grade 5, 10 Grade 6 and 10 Grade 7 scores. 25 patients (54%) developed aspiration (5 trace, 20 severe). The aspiration rate for T1-T2 and T3-T4 tumours was 31% and 67%, respectively (p = 0.03). There was no statistical difference in the aspiration rate between the base of the tongue and tonsillar carcinoma (p = 0.23). Despite anatomical organ preservation, most patients with locally advanced oropharyngeal carcinoma had moderate to severe dysphagia after chemoradiation. Patients with large tumours had a significant risk of developing aspiration following treatment.


Oncology | 2008

Impact of Tumor Board Recommendations on Treatment Outcome for Locally Advanced Head and Neck Cancer

Nam P. Nguyen; Paul Vos; Howard Lee; Thomas L. Borok; Ulf Karlsson; Tomas Martinez; James S. Welsh; Deirdre Cohen; Russell J. Hamilton; Nga Nguyen; Ly M. Nguyen; Vincent Vinh-Hung

Background/Aims: To identify physician selection factors in the treatment of locally advanced head and neck cancer and how treatment outcome is affected by Tumor Board recommendations. Methods: A retrospective analysis of 213 patients treated for locally advanced head and neck cancer in a single institution was performed. All treatments followed Tumor Board recommendations: 115 patients had chemotherapy and radiation, and 98 patients received postoperative radiation. Patient characteristics, treatment toxicity, locoregional control and survival between these two treat- ment groups were compared. Patient survival was compared with survival data reported in randomized studies of locally advanced head and neck cancer. Results: There were no differences in comorbidity factors, and T or N stages between the two groups. A statistically significant number of patients with oropharyngeal and oral cavity tumors had chemoradiation and postoperative radiation, respectively (p < 0.0001). Grade 3–4 toxicities during treatment were 48 and 87% for the postoperative radiation and chemoradiation groups, respectively (p = 0.0001). There were no differences in survival, locoregional recurrences and distant metastases between the two groups. Patient survival was comparable to survival rates reported by randomized studies of locally advanced head and neck cancer. Conclusion: Disease sites remained the key determining factor for treatment selection. Multidisciplinary approaches provided optimal treatment outcome for locally advanced head and neck cancer, with overall survival in these patients being comparable to that reported in randomized clinical trials.


Operations Research Letters | 2007

Aspiration Rate following Nonsurgical Therapy for Laryngeal Cancer

Nam P. Nguyen; Candace C. Moltz; Cheryl Frank; Paul Vos; Carrie Millar; Herbert J. Smith; Howard Lee; Ulf Karlsson; Phuc D. Nguyen; Tomas Martinez; Ly M. Nguyen; Sabah Sallah

The aim of this study was to evaluate the aspiration rate following nonsurgical therapy, i.e. chemoradiation or radiation alone for laryngeal cancer. Modified barium swallow was performed in 43 patients who complained of dysphagia following chemoradiation (n = 22) or radiation alone (n = 21) for laryngeal cancer. Patients were selected if they were cancer free at the time of the swallowing study. Dysphagia severity was graded on a scale of 1–7. Patients were grouped according to the dysphagia severity: no aspiration (grade 1–4), and severe (grade 5–7). Mean and median dysphagia grades were 4.4/5 and 3.5/3 for chemoradiation and radiation, respectively. Aspiration occurred in 12 patients (54%) of the chemoradiation group and 7 (33%) of the radiation alone group (p = 0.13). There was a higher proportion of patients with large tumor (T3–T4) in the chemoradiation group (64%) compared to the radiation group (5%) (p = 0.0001). Aspiration is a significant source of morbidity in patients treated for laryngeal cancer with chemoradiation or radiation alone. Aspiration occurred in both groups. Although the observed difference in aspiration rates did not achieve statistical significance, the higher aspiration rate in the chemoradiation group may be due to a higher proportion of large tumors, to the additional toxic effect of chemotherapy, or to the small number of patients in both groups. Diagnostic studies such as modified barium swallow should be part of future laryngeal cancer prospective studies to assess the prevalence of aspiration as it may be silent.


Lung | 2007

Effectiveness of the Cough Reflex in Patients with Aspiration Following Radiation for Head and Neck Cancer

Nam P. Nguyen; Candace C. Moltz; Cheryl Frank; Carrie Millar; Herbert J. Smith; Suresh Dutta; Phuc D. Nguyen; Ly M. Nguyen; Claire Lemanski; Adir Ludin; Beng-Hoey Jo; Sabah Sallah

The effectiveness of the cough reflex in patients who aspirated following radiation for head and neck cancer was evaluated in 89 patients (49 chemoradiation, 33 postoperative radiation, and 7 radiation alone). All patients had modified barium swallow because of dysphagia. The cough reflex was graded as present and effective, ineffective, intermittently effective, or absent. All patients were cancer-free at the time of the swallowing study. The cough reflex was present and effective in 46 patients (52%), ineffective in 17 patients (19%), and absent in 26 patients (29%) on initial investigation. Among the 43 patients who had ineffective or absent cough reflex, their treatment was chemoradiation (26), postoperative radiation (13), and radiation alone (4). In 30 patients who had sequential modified barium swallow, the cough reflex was constantly effective, ineffective, or intermittently effective in 12 (40%), 13 (43%), and 5 (17%) patients, respectively. The cough reflex was frequently ineffective or absent in patients who aspirated following radiation for head and neck cancer. Cough may also be intermittently ineffective to protect the airways following radiation.


Operations Research Letters | 2007

Quality of Life following Chemoradiation and Postoperative Radiation for Locally Advanced Head and Neck Cancer

Nam P. Nguyen; Paul Vos; Ulf Karlsson; Phuc D. Nguyen; Suresh Dutta; Claire Lemanski; Adir Ludin; Sue Rose; Ly M. Nguyen; Harold Wc. Ward; Shawn Huang; Sabah Sallah

Background: To evaluate the impact of chemoradiation and postoperative radiation on patients’ quality of life (QOL) in a single institution. Methods: A retrospective analysis of 101 patients who had treatment for locally advanced head and neck cancer in a single institution. Forty-seven patients had chemotherapy and radiation, 54 patients underwent postoperative radiation. QOL was assessed with the University of Washington (UW), and the Hospital Anxiety (HA) and Depression (HD) questionnaires. All patients were free of disease at the survey time. Results: Mean and median UW scores were not different between the 2 groups: chemoradiation (65/67), postoperative radiation (62/63). Mean and median HA scores were 7.6/7 (chemoradiation), and 8.3/8 (postoperative radiation). Mean and median HD scores were 6.7/7 (chemoradiation), and 7.1/7 (postoperative radiation). Forty-four patients developed complications, with mean/median UW, HA, and HD scores of 55/55, 9.9/8, and 8.9/9, respectively. These scores were significantly different compared to the 57 patients without complications: 70/70 (p = 0.0001), 6.5/6 (p = 0.001), and 8.9/9 (p = 0.0001). Conclusion: There was no significant difference in QOL between chemoradiation and postoperative radiation in this retrospective study with a relatively short follow-up in the chemoradiation group. In addition, there were more patients with resectable disease in the postoperative group which may explain the lack of difference in QOL between the two groups. Patients who developed complications following treatment experienced lower QOL, more anxiety and depression. Our study raised the need to conduct a prospective randomized study to assess the real impact of chemoradiation and postoperative radiation on patients’ QOL.


Oncology | 2008

Long-Term Aspiration following Treatment for Head and Neck Cancer

Nam P. Nguyen; Candace C. Moltz; Cheryl Frank; Paul Vos; Herbert J. Smith; Ulf Karlsson; Ly M. Nguyen; Sue Rose; Suresh Dutta; Nga Nguyen; Sabah Sallah

Background: Dysphagia and aspiration are long-term complications with life-threatening consequences following treatment of head and neck cancer. We would like to assess the prevalence of aspiration in patients with long-term persistence of dysphagia (1 year or more) following treatment for head and neck cancer and to identify potential risk factors of aspiration. Methods: Modified barium swallow (MBS) examinations were performed in cancer-free patients who complained of dysphagia following treatment for head and neck cancer. The severity of the dysphagia was graded on a scale of 1–7. Results: Between 1992 and 2004, 74 patients with dysphagia underwent MBS 12–152 months following treatment (median 29 months). There were 2 grade 1, 22 grade 3, 21 grade 4, 11 grade 5, 7 grade 6, and 11 grade 7 cases. Twenty-nine patients (39%) had long-term aspiration at a median follow-up of 25 months (range 12–82). Eighteen patients (24%) required permanent gastrostomy because of severe aspiration. Type of treatment and disease stage did not seem to influence long-term aspiration risk. Conclusion: Patients with long-term dysphagia after treatment for head and neck cancer are at risk of aspiration. MBS should be performed to identify these patients.


British Journal of Radiology | 2008

Analysis of the factors influencing dysphagia severity upon diagnosis of head and neck cancer

Nam P. Nguyen; Paul Vos; C. C. Moltz; C. Frank; C. Millar; Herbert J. Smith; Suresh Dutta; Alan A. Alfieri; H. Lee; T. Martinez; Ulf Karlsson; Ly M. Nguyen; Sabah Sallah

Our aim was to assess the influence of age, co-morbidity factors and tumour characteristics on dysphagia severity in the diagnosis of head and neck cancer. Modified barium swallow (MBS) examinations were performed in patients at diagnosis of head and neck cancer. Dysphagia was graded on a scale of 1 to 7 of increasing severity. Between 2000 and 2006, 236 patients with dysphagia underwent MBS at diagnosis of their head and neck cancer. 82 patients were scored as Grade 1, 88 as Grade 2, 29 as Grade 3, 15 as Grade 4, 9 as Grade 5, 5 as Grade 6, and 8 as Grade 7. Grade 3-7 dysphagia occurred in 20% and 31% of patients with T1-T2 and T3-T4 tumours, respectively (p = 0.004). Corresponding values for N0-N1 and N2-N3 tumours were 20% and 39%, respectively (p = 0.002). The percentage of patients with Grade 3-7 dysphagia was 5%, 29%, 33% and 52% for oral cavity, laryngeal, oropharyngeal and hypopharyngeal tumours, respectively, (p = 0.002). Age and co-morbidity factors (e.g. diabetes, hypertension, coronary artery disease, peripheral vascular diseases and arthritis) did not appear to have an impact on swallowing in this limited retrospective study. Patients with locally advanced stages (T3-T4, N2-N3) are at risk of severe dysphagia. Patients with oral cavity tumours appear to be less at risk of dysphagia than those with tumours in different anatomic locations. The role of age and co-morbidity factors should be investigated in future prospective studies.

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Nam P. Nguyen

East Carolina University

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Paul Vos

East Carolina University

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Herbert J. Smith

University of Texas Southwestern Medical Center

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Suresh Dutta

University of Southern California

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Candace C. Moltz

University of Texas Southwestern Medical Center

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Cheryl Frank

University of Texas Southwestern Medical Center

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Phuc D. Nguyen

University of Texas Southwestern Medical Center

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Sabah Sallah

University of North Carolina at Chapel Hill

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Sabah Sallah

University of North Carolina at Chapel Hill

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