M. A. Hanna

Synthesis of novel 4-substituted phenazone derivatives as potential antibacterial and antineoplastic agents

A new series of substituted phenazone derivatives has been prepared, through a series of reactions that are illustrated in Scheme I. The antibacterial and antineoplastic activities of the prepared compounds were evaluated. While none of the synthesized products showed marked antibacterial activity, all of them possessed a significant antitumor effect.

NOVEL SULPHOARYLAZO 4-PYRAZOLONE-BASED TARTRAZINE DYE ANALOGUES

In a multistep synthesis, a novel series of 4-pyrazolone–based tartrazine dye analogues were prepared benzimidazol-5-yl acetoacetamide derivative I. Chemical structure of the hitherto prepared dyestuffs were confirmed on the basis of correct elemental analysis as well as spectral data. The degree of exhaustion of the hitherto synthesized 3-[2-(oxoimidazo-5-yl) carboxamido] tartrazine dye analogues was determined and found to be in the range of 92.6–97.8%. The latter high ratios might be ascribed to the presence of the cyclic amide function in structure of these dyestuffs.

NOVEL SULFUR CONTAINING AGRO CHEMICALS: SYNTHESIS OF MERCAPTOTRIAZOLES, TRIAZOLO-(3,4-b)-THIADIAZOLE, TRIAZOLO-(3,4-b)-THIADIAZINE AND TRIAZOLO-(3,4-b)-THIADIAZEPINE RING SYSTEMS AS POSSIBLE FUNGITOXIC AGENTS

Abstract A series compounds II–XII have been synthesized from the stereo-isomeric 4-{4-(Z)-[p-(benzenesul-fonyloxy)phenylmethylene]-5-oxo-1- phenyl-2-imidazolin-1-yl)-benzoic acid hydrazide derivative (I) in order to investigate the fungitoxic activity of the compounds against Rice blast pathogen “Pyricularia oryzae” and Brown leaf spot pathogen “Helminthosporium oryzae” and the possibility of their use as new sulfur-containing agro chemicals. Fungitoxicity of most of the synthesized products compared well with a standard commercial fungicide. The assigned structures for these potential fungitoxic agents were established by elemental analyses, spectral data and whenever possible by alternative synthetic routes.

C-13 NMR Spectra of N-Aminopyridinium Perchlorates

Abstract C-13 NMR spectra of fifteen N-aminopyridinium perchlorates show the effect of amination of the ring nitrogen atom to be similar to that observed in the pyridine N-oxide spectra, particularly for the 2(6) and 3(5) positions. Benzene and pyridine increments predict well the carbon chemical shifts for the title compounds unless both positions 2 and 6 are occupied. The chemical shifts of some carbon atoms in the compounds studied are linearly dependent on those in the respective benzene derivatives as well as on the Hammett σ constants.

Activated thiocyanates in the synthesis of heterocyclic hansa yellow analogues. Synthesis and colour measurements of 1-(5'-imino-4'-phenyl-4',5'-dihydro-1',3',4'-(hiadiazol-2'-yl)-3(pyrid-2'-yl)amiono-1,2,3-trioxopropane 2-arylhydrazone derivatives as dyes for synthetic-polymer fibres

Abstract In a sequence of reactions the activated thiocyanate derivative 2 was used to synthesize new Hansa Yellow dyestuffs embodying two heterocyclic moieties. The structure of the dyes was inferred from spectral and analytical data. Spectral behaviour of the dyes indicated that they existed essentially in the hydrazone form (5-C). Dyeings of the compounds on polyester were assessed with a view to evaluating the percentage reflectance of the dyed fibre at different wave-lengths in the visble region and the Kubelka-Munk equation was used to calculate the K S function of the dyed materials.

Simple Approach to Some New Arylazo Spiro Indoline-Based Dyes as Alternatives for Benzidine-Based Dyestuffs

Three categories of mono, dis- and tris arylazo dyestuffs, which are based on the spiro 2-oxoindole (3,2′) thiazolone moiety, have been synthesized. The assigned structures for the prepared dyes were confirmed on the basis of elemental analysis, as well as spectral data, and whenever possible, by alternative synthetic routes. Moreover, the predominant tautomeric structures for these highly colored products were tested and discussed on the basis of their spectral behavior.

Anchored Synthesis for Some Novel Mono and Disarylazo 1,2,4-Benzothiadiazine-Based Dyestuffs as Alternatives for Benzidine-Based Dyes

A one mono and two disarylazo series of 1,2,4-benzothiadiazine-based dyestuffs has been synthesized with a view that these products, with their new all-round tinctorial properties, might find an application as new categories of direct dyes that satisfactorily replace prohibited benzidine-based dyes. The assigned structures for the hitherto prepared dyes were confirmed on the basis of elemental analysis as well as spectral data and, whenever possible, by alternative synthetic routes. Moreover, the predominant tautomeric structures for these highly colored products were tested and discussed on the basis of their spectral behavior.