M. M. Girges
Mansoura University
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Featured researches published by M. M. Girges.
Monatshefte Fur Chemie | 2003
Tarek A. Salama; Abdel-Aziz S. El-Ahl; Abdel-Galil M. Khalil; M. M. Girges; Bernd Lackner; Christian Steindl; Saad S. Elmorsy
Summary. Several new 1-aryl-, aralkyl-, and heteroaryl-5-(4-phenylbuta-1,3-dienyl)tetrazole derivatives and annulated tetrazole derivatives were efficiently and regiospecifically prepared in nearly quantitative yield via a facile one step reaction of dienones with a combination of tetrachlorosilane and sodium azide in acetonitrile under mild conditions. A complete structure assignment of three representative examples of the tetrazoles was achieved by advanced 2D NMR measurements including COSY, TOCSY, HSQC, HMBC, NOESY, and ROESY experiments.
Tetrahedron Letters | 1997
Saad S. Elmorsy; Abdel Galel.M. Khalil; M. M. Girges; Tarek A. Salama
Abstract The successive reactions of some cyclic ketones with aryl methyl ketones mediated by tetrachlorosilane-ethanol, provide an attractive and convenient route to branched functionalized benzenoid compounds. Selective unsymmetrical branched triarylbenzenes have synthesized by inducing the reaction of ketones with dypnones in quantitative yields.
Synthetic Communications | 2007
Tarek A. Salama; Saad S. Elmorsy; Abdel-Galel M. Khalil; M. M. Girges; Abdel-Aziz S. El-Ahl
Abstract A combination of tetrachlorosilane and potassium cyanide (in situ trichlorosilyl cyanide) was found to work efficiently for hydrocyanation of ketones to afford the corresponding cyanohydrins in high yield under mild conditions.
Archives of Pharmacal Research | 1988
M. M. Girges; M. M. Abou El-Zahab; M. A. Hanna
A new series of substituted phenazone derivatives has been prepared, through a series of reactions that are illustrated in Scheme I. The antibacterial and antineoplastic activities of the prepared compounds were evaluated. While none of the synthesized products showed marked antibacterial activity, all of them possessed a significant antitumor effect.
Phosphorus Sulfur and Silicon and The Related Elements | 2004
E. M. Keshk; A. A. Abu-Hashem; M. M. Girges; Abdel-Rahman H. Abdel-Rahman; Farid A. Badria
Benzo[1,2-b:5,4-b′]difuran-2-carbohydrazides 5a, b were reacted with aryl or alkyl isothiocyanates to give the corresponding thiosemicarbazides 6a–h. Cyclization of the substituted thiosemicarbazides with sodium hydroxide led to the formation of benzo[1,2-b:5,4-b′]difuranyl-1,3,4-triazoles 7a–f. Desulfurization of thiosemicarbazides by mercuric oxide gave benzo[1,2-b:5,4-b′]difuranyl-1,3,4-oxadiazoles 8a–f. Treatment of thiosemicarbazides with ethyl bromoacetate or α-bromopropionic acid yielded benzo[1,2-b:5,4-b′]difuranyl-carbonyl-hydrazono-4-thiazolidinones 9a–f and 10a–f, respectively. Furthermore, the reaction of the thiosemicarbazides with phosphorus oxychloride gave benzo[1,2-b:5,4-b′]difuranyl-1,3,4-thiadiazoles 11a–f. Some compounds in this study were biologically evaluated for their ability to bind to DNA.
Phosphorus Sulfur and Silicon and The Related Elements | 1991
M. A. Hanna; M. M. Girges; Moged A. Berghot
Abstract The stereospecific synthesis for a series of (Z)-4-{2-Aryl-4-[4-(arylsulfonyloxy)phenylmethinyl]-4,5-dihydro-5-oxo-1H-imidazol-1-yl)-N-substituted benzenesulfonamide derivatives (VIa-o) was investigated with a view to prepare new pharmacologically active products of extended and/or improved antineoplastic activity. Owing to the weak nucleophilicity of the nitrogen nucleophiles under investigation, acetic acid mediated cyclizations were followed for preparation of the required products. Additionally, the antimicrobial activity was screened for the compounds reported.
Medicinal Chemistry | 2013
Hadeer Fakhr Eldien; M. M. Girges; Moged A. Berghot
A series of aryl azonaphthoquinones 8a-e were obtained via coupling of the corresponding diazonium salts 7a-c with naphthoquinones 2 or 3 in pyridine. Moreover, treatment of 5 with 6a, b in ethanol containing potassium carbonate afforded the corresponding enaminones 9a, b, respectively. Furthermore, heating of 6a with 2-hydroxy-3-((piperidn- 1-yl)methyl)naphthalene-1,4-dione 10 in EtOH/AcOHor sodium 3,4-dihydro-3,4-dioxonaphthalene-1-sulphonate 1 in MeOH/H2O afforded the corresponding enaminones 11 and 12, respectively. The newly synthesized compounds were screened for their antioxidant activity. Compounds 8b 89.87, 9a (89.93%) and 9b (95.97%) exhibited promising activities. On the other hand compounds 8b, 9a, 9b, 11 and 12 have the ability to protect DNA from the damage induced by bleomycin.
Journal of Chemical Research-s | 1997
Saad S. Elmorsy; Abdel Galel.M. Khalil; M. M. Girges; Tarek A. Salama
Many β-methylchalcone derivatives are prepared via the self condensation of aralkyl ketones mediated by tetrachlorosilane–ethanol under mild conditions.
Journal of Saudi Chemical Society | 2016
Hadeer Fakhr Eldien; M. M. Girges; Moged A. Berghot
Journal of Chemical Technology & Biotechnology | 2007
M. A. Hanna; M. M. Girges; A. A. Fadda