M. A. Malenkovskaya

NMR study of inclusion complexes formation between amphiphilic dimeric β-cyclodextrin derivative and some pharmacologically important compounds

With the use of monotosyl β-cyclodextrin derivative and 1,6-hexanediamine the new dimeric (bridged) amphiphilic derivative was obtained, and the opportunity to form on its base inclusion complexes of “guest–host” type with some pharmacologically important compounds was demonstrated by 1H and 13C NMR spectroscopy.

Synthesis and complex formation ability of monomeric and dimeric amphiphilic β-cyclodextrin derivatives

Applying 6-O-monotosyl derivative of β-cyclodextrin and hexane-1,6-diamine monomeric and dimeric (bridging) amphiphilic compounds were obtained, and the opportunity was demonstrated of the preparation on their basis of inclusion compounds at the interaction with 2-(4-isobutylphenyl)propionic acid (Ibuprofen).

Amphiphilic conjugates of β-cyclodextrin with acetylsalicylic and 2-(4-isobutylphenyl)propionic acids

New amphiphilic β-cyclodextrin derivatives containing pharmacologically important aromatic and aliphatic monocarboxylic acid fragments at both primary and secondary hydroxy groups were synthesized with the use of palmitic, acetylsalicylic, and 2-(4-isobutylphenyl)propionic acid chlorides. The position of the acyl groups in the carbohydrate fragments of β-cyclodextrin was determined by 13C NMR spectroscopy.

New phosphorus-containing macroheterocyclic cavitands

Previously unknown phosphorus-containing macroheterocycles were prepared from an accessible symmetrical dipentaerythritol derivative and trivalent phosphorus compounds. The difference in the properties of the phosphocycles containing one and two phosphoric functions was revealed.

NMR spectroscopy study of complex formation between dimeric derivative of β-cyclodextrine and some pharmacologically important compounds

The formation of inclusion compounds of β-cyclodextrine with a series of pharmacologically important compounds was studied using 1H and 13C NMR spectroscopy.

New synthetic approaches to development of the chemistry of pentaerythritol bicyclophosphite

Syntheses of the original compact molecular systems were developed and the ways of their practical use were examined. A group of new substances was synthesized on the basis of available penta-erythritol bicyclophosphite and thionophosphate, including respective ammonium salts, phosphocholines, a complex compound of molybdenum, and a hydrophosphoryl compound.

Structure and chemical transformations of dipentaerythritol bisbicyclophosphite

First data on the chemical properties of dipentaerythritol bisbicyclophosphite and — thionophosphate are presented. The structures of the bisbicyclophosphite and its molybdenum complex are established by X-ray diffraction analysis.

Diphosphites derived from 1,3:1′,3′-di-O-benzylidenedipentaerythritol—key synthons for new types of phosphorus-containing compounds

A number of cyclic diphosphites were synthesized on the basis of an accessible diol, 1,3:1′,3′-di-O-benzylidenedipentaerythritol. The resulting diphosphites were converted into complex covalent and coordination organophosphorus compounds.

The first representatives of dipentaerythrite perphosphites

The first representatives of dipentaerythrite perphosphites were prepared by phosphorylation of aliphatic hexaol dipentaerythrite with 1,3-alkylenchloro-and 1,3-alkylenamidophosphites. The processes of oxidation, sulfurization, hydrolysis, and complex formation of the prepared compounds were investigated.

Dipentaerethrite in the synthesis of model amidophosphate phospholipids

A productive method for the synthesis of original phospholipid architectures is developed based on the available reagent dipentaerythritol. Introduction of the phosphoric function to the system is achieved by using phosphoric hexaethyltriamide.