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Dive into the research topics where M. Del Prete is active.

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Featured researches published by M. Del Prete.


Annals of Oncology | 2014

531PNEUTROPHIL/LYMPHOCYTE RATIO AND PIASTRINOSIS CORRELATE WITH CLINICAL OUTCOME IN METASTATIC COLORECTAL CANCER PATIENTS RECEIVING REGORAFENIB

Riccardo Giampieri; M. Del Prete; Fotios Loupakis; Lisa Salvatore; Tiziana Prochilo; Luca Faloppi; Giuseppe Aprile; Maristella Bianconi; Alessandro Bittoni; Alfredo Falcone; Alberto Zaniboni; Mario Scartozzi; Stefano Cascinu

ABSTRACT Aim: A non-negligible proportion of colorectal cancer patients receiving regorafenib does not seem to benefit from such a treatment approach and are then exposed to unnecessary toxicity. Neutrophil/lymphocyte ratio and piastrinosis (platelet number increase) may represent indirect indicator of tumour induced inflammation and angiogenesis and have been suggested to influence patients’ outcome. Our analysis investigated the role of neutrophil/lymphocyte ratio and piastrinosis in pretreated metastatic colorectal cancer patients receiving regorafenib. Methods: We collected neutrophil, lymphocyte and platelet count at the start of treatment. Cut-off values for neutrophil/lymphocyte ratio and platelets were calculated by ROC curve analysis. Other tested variables were: age, sex, performance status, k-ras status, number of metastatic sites, previous adjuvant chemotherapy, number of previous systemic anticancer therapies, Overall survival (OS) and progression free survival (PFS) were calculated by Kaplan-Meier method, multivariate analysis was performed by Cox method. Results: 208 patients were eligible. In the global population median OS was 4.2 months whereas median PFS was 2.4 months. Ten (5%) achieved a partial response, 58 (29%) disease stabilization and the remaining 134 (66%) progressed under treatment. The cut off value for piastrinosis and neutrophil/lymphocyte ratio was determined at 0.545 ULN and 0.381 respectively. At univariate analysis neutrophil/lymphocyte ratio and piastrinosis both correlated with clinical outcome. At multivariate analysis a high platelet count and high neutrophil/lymphocyte ratio were related to a worse OS (Exp(b):1.49, 95%CI:1.0130-2.2103, p = 0.0439 and Exp(b):1.6963, 95%CI: 1.0757-2.6751, p = 0.0237 respectively) and PFS (Exp(b):1.4985, 95% CI: 1.0925-2.0556, p = 0.0126 and Exp(b): 1.9277, 95% CI: 1.3226-2.8097, p = 0,0007 respectively). Interestingly in 52 (25%) patients negative for these factors, median overall survival was 15.9 months vs. 3.1 months for patients harbouring at least one of the factors examined (HR:3.81, 95% CI:2.3260-4.8274, p Conclusions: Our analysis suggests that a high platelet count and a high neutrophil/lymphocyte ratio are predictive factors for clinical outcome in patients treated with regorafenib. Disclosure: All authors have declared no conflicts of interest.


Annals of Oncology | 2017

D19Locoregional treatments and sites of metastatic involvement in metastatic gastric cancer patients: do they influence survival?

Luca Cantini; Riccardo Giampieri; M Palladino; M. Del Prete; Alessandro Bittoni; E Giglio; Tania Meletani; G M Baleani; Elena Maccaroni; M Di Pietro Paolo; Rossana Berardi


Annals of Oncology | 2017

H8Prognostic impact of CA15-3 pre-treatment levels in ovarian cancer patients

Elena Maccaroni; Riccardo Giampieri; M. Del Prete; G Principi; R. Bracci; A Calcinari; A. Della Mora; F. Bianchi; L. Belvederesi; C. Brugiati; Silvia Pagliaretta; Mirco Pistelli; Agnese Savini; A. Pagliacci; Z. Ballatore; F Bini; Maria Giuditta Baleani; Luca Cantini; A Murrone; Rossana Berardi


Annals of Oncology | 2017

A27Primary tumor site (pTS) as a key factor in adjuvant treatment decision in resected N+ colorectal cancer patients

Riccardo Giampieri; Andrea Lanese; G Pusole; M. Del Prete; Alessandro Bittoni; Luca Cantini; Elena Maccaroni; Valeria Pusceddu; S Delprete; Miriam Caramanti; Tania Meletani; Maria Giuditta Baleani; M Di Pietro Paolo; Mario Scartozzi; Rossana Berardi


Journal of Hepatology | 2015

P0323 : LDH serum levels as prognostic and predictive factor in advanced biliary tract cancer patients treated with first line chemotherapy

Luca Faloppi; M. Del Prete; Maristella Bianconi; Daniele Santini; Nicola Silvestris; A. Casadei Gardini; Oronzo Brunetti; Riccardo Giampieri; Mario Scartozzi; Stefano Cascinu


Journal of Hepatology | 2015

P0313 : Correlation between VEGF and VEGF-R polymorphisms, toxicity and clinical outcome in HCC patients receiving sorafenib

Luca Faloppi; Maristella Bianconi; G. Svegliati Baroni; A. Casadei Gardini; Nicola Silvestris; Gianluca Masi; Paola Ulivi; Caterina Vivaldi; Riccardo Giampieri; M. Del Prete; Antonio Benedetti; Mario Scartozzi; Stefano Cascinu


European Journal of Cancer | 2015

2580 Multigene profiling in incidentally- and clinically detected prostate cancer

Maristella Bianconi; Luca Faloppi; Antonio Zizzi; R. Mazzucchelli; Riccardo Giampieri; Alessandro Bittoni; Kalliopi Andrikou; M. Del Prete; Mario Scartozzi; Rodolfo Montironi; S. Cascinu


European Journal of Cancer | 2015

2390 LDH serum levels as prognostic and predictive factor in advanced biliary tract cancer patients treated with first line chemotherapy

Luca Faloppi; M. Del Prete; A. Casadei Gardini; Daniele Santini; Nicola Silvestris; Maristella Bianconi; Riccardo Giampieri; Alessandro Bittoni; Kalliopi Andrikou; Martina Valgiusti; Oronzo Brunetti; Mario Scartozzi; S. Cascinu


Annals of Oncology | 2015

E42Role of different toxicity profile on outcome for colorectal cancer patients receiving Regorafenib monotherapy

Riccardo Giampieri; M. Del Prete; Luca Faloppi; Maristella Bianconi; Kalliopi Andrikou; Alessandro Bittoni; Elena Maccaroni; S. Cascinu


Annals of Oncology | 2015

L09Mismatch repair protein expression and Hedgehog signalling pathways in human pancreatic cancer

Alessandro Bittoni; Kalliopi Andrikou; Matteo Santoni; Riccardo Giampieri; Alessandra Mandolesi; Chiara Pellei; Luca Faloppi; Cristian Loretelli; Andrea Lanese; M. Del Prete; Elena Maccaroni; Maristella Bianconi; Stefano Cascinu

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Riccardo Giampieri

Marche Polytechnic University

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Luca Faloppi

Marche Polytechnic University

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Maristella Bianconi

Marche Polytechnic University

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Alessandro Bittoni

Marche Polytechnic University

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Elena Maccaroni

Marche Polytechnic University

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Stefano Cascinu

University of Modena and Reggio Emilia

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Kalliopi Andrikou

Marche Polytechnic University

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