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Dive into the research topics where M. Dobrijevic is active.

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Featured researches published by M. Dobrijevic.


Journal of Physical Chemistry A | 2009

How Measurements of Rate Coefficients at Low Temperature Increase the Predictivity of Photochemical Models of Titan’s Atmosphere†

Eric Hébrard; M. Dobrijevic; Pascal Pernot; Nathalie Carrasco; Astrid Bergeat; Kevin M. Hickson; André Canosa; S. D. Le Picard; Ian R. Sims

The predictivity of photochemical models of Titans atmosphere depends strongly on the precision and accuracy of reaction rates. For many reactions, large uncertainty results from the extrapolation of rate laws to low temperatures. A few reactions have been measured directly at temperatures relevant to Titans atmosphere. In the present study, we observed the consequences of the reduced uncertainty attributed to these reactions. The global predictivity of the model was improved, i.e., most species are predicted with lower uncertainty factors. Nevertheless, high uncertainty factors are still observed, and a new list of key reactions has been established.


Astrobiology | 2009

Monte Carlo Simulation of the Radiation Environment Encountered by a Biochip During a Space Mission to Mars

A. Le Postollec; S. Incerti; M. Dobrijevic; L. Desorgher; G. Santin; P. Moretto; Odile Vandenabeele-Trambouze; Gaëlle Coussot; L. Dartnell; P. Nieminen

Simulations with a Monte Carlo tool kit have been performed to determine the radiation environment a specific device, called a biochip, would face if it were placed into a rover bound to explore Mars surface. A biochip is a miniaturized device that can be used to detect organic molecules in situ. Its specific detection part is constituted of proteins whose behavior under cosmic radiation is completely unknown and must be investigated to ensure a good functioning of the device under space conditions. The aim of this study is to define particle species and energy ranges that could be relevant to investigate during experiments on irradiation beam facilities. Several primary particles have been considered for galactic cosmic ray (GCR) and solar energetic particle (SEP) contributions. Ionizing doses accumulated in the biochip and differential fluxes of protons, alphas, neutrons, gammas, and electrons have been established for both the Earth-Mars transit and the journey at Mars surface. Neutrons and gammas appear as dominant species on martian soil, whereas protons dominate during the interplanetary travel. Depending on solar event occurrence during the mission, an ionizing dose of around a few Grays (1 Gy = 100 rad) is expected.


Astrobiology | 2009

Investigation of Neutron Radiation Effects on Polyclonal Antibodies (IgG) and Fluorescein Dye for Astrobiological Applications

A. Le Postollec; Gaëlle Coussot; Mickael Baqué; S. Incerti; I. Desvignes; P. Moretto; M. Dobrijevic; Odile Vandenabeele-Trambouze

Detecting life in the Solar System is one of the great challenges of new upcoming space missions. Biochips have been proposed as a way to detect organic matter on extraterrestrial objects. A biochip is a miniaturized device composed of biologically sensitive systems, such as antibodies, which are immobilized on a slide. In the case of in situ measurements, the main concern is to ensure the survival of the antibodies under space radiation. Our recent computing simulation of cosmic ray interactions with the martian environment shows that neutrons are one of the dominant species at soil level. Therefore, we have chosen, in a first approach, to study antibody resistance to neutrons by performing irradiation experiments at the Applications Interdisciplinaires des Faisceaux dIons en Région Aquitaine (AIFIRA) platform, a French ion beam facility at the Centre dEtudes Nucléaires de Bordeaux-Gradignan in Bordeaux. Antibodies and fluorescent dyes, freeze-dried and in buffer solution, were irradiated with 0.6 MeV and 6 MeV neutrons. Sample analyses demonstrated that, in the conditions tested, antibody recognition capability and fluorescence dye intensity are not affected by the neutrons.


Astrobiology | 2011

Investigation of Low-Energy Proton Effects on Aptamer Performance for Astrobiological Applications

Mickael Baqué; A. Le Postollec; C. Ravelet; E. Peyrin; Gaëlle Coussot; I. Desvignes; S. Incerti; P. Moretto; M. Dobrijevic; Odile Vandenabeele-Trambouze

Biochips are promising instruments for the search for organic molecules in planetary environments. Nucleic acid aptamers are powerful affinity receptors known for their high affinity and specificity, and therefore are of great interest for space biochip development. A wide variety of aptamers have already been selected toward targets of astrobiological interest (from amino acids to microorganisms). We present a first study to test the resistance of these receptors to the constraints of the space environment. The emphasis is on the effect of cosmic rays on the molecular recognition properties of DNA aptamers. Experiments on beam-line facilities have been conducted with 2 MeV protons and fluences much higher than expected for a typical mission to Mars. Our results show that this irradiation process did not affect the performances of DNA aptamers as molecular recognition tools.


Archive | 2009

Method for detecting and quantifying a molecule including at least one protonated group on a solid substrate

Gaëlle Coussot; Odile Vandenabeele-Trambouze; Isabelle Desvignes; M. Dobrijevic; Aurélie Le Postollec; Pascale Chazalnoel


Journées SF2A 2007 Semaine de l'Astrophysique Française 2007 2 au 6 juillet 2007 | 2006

DEVELOPMENT OF A BIOCHIP DEDICATED TO PLANETARY EXPLORATION. FIRST STEP: RESISTANCE STUDIES TO SPACE CONDITIONS

A. Le Postollec; M. Dobrijevic; S. Incerti; Ph. Moretto; H. Seznec; L. Desorgher; G. Santin; P. Nieminen; L. Dartnell; O. Vandenabeele-Trambouze; G. Coussot


Faraday Discussion 147: Chemistry of the Planets. St-Jacut de la Mer, France. 14-16 june 2010. | 2010

Thermo-photochemistry of exoplanet atmospheres.

Olivia Venot; M. Dobrijevic; Franck Selsis; Eric Hébrard; All And


35th Seminar Esreda On "Uncertainty in Industrial Practice - Generic best practices in uncertainty treatment" | 2008

Structured description of uncertainty for chemical reaction products and rates

Pascal Pernot; S. Plessis; Nathalie Carrasco; Eric Hébrard; M. Dobrijevic; Valentine Wakelam


Archive | 2001

Molecular origins of life: peptide prebiotic emergence and evolution through a permanent, cyclic molecular engine (the primary pump). Influence on the emergence of homochirality

Laurent Boiteau; Hélène Collet; Herve Collet; Olivier Lagrille; Raphaël Plasson; Jean-Philippe Biron; Odile Vandenabeele-Trambouze; Jacques Taillades; Auguste Commeyras; Franck Selsis; M. Dobrijevic; Hervé Martin


Science Trends | 2018

Deducing Jupiter’s Stratospheric Circulation From Its Composition

Vincent Hue; Franck Hersant; T. Cavalié; M. Dobrijevic; J. A. Sinclair

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Eric Hébrard

Centre national de la recherche scientifique

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Franck Selsis

Centre national de la recherche scientifique

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S. Incerti

University of Bordeaux

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Olivia Venot

Katholieke Universiteit Leuven

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Gaëlle Coussot

University of Montpellier

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P. Moretto

University of Bordeaux

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Mickael Baqué

University of Rome Tor Vergata

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