M.-H. Richard

Design Guidelines for a Double Scattering Compton Camera for Prompt-

In hadrontherapy in order to fully take advantage of the assets of the ion irradiation, the position of the Bragg peak has to be monitored accurately. Here, we investigate a monitoring method relying on the detection in real time of the prompt γ emitted quasi instantaneously during the nuclear fragmentation processes. Our detection system combines a beam hodoscope and a double scattering Compton camera. The prompt-γ emission points are reconstructed by intersecting the ion trajectories given by the hodoscope and the Compton cones reconstructed with the camera. We propose here to study in terms of point spread function and efficiency the theoretical feasibility of the emission points reconstruction with our set-up in the case of a photon point source in air. First we analyze the nature of all the interactions which are likely to produce an energy deposit in the three detectors of the camera. It is underlined that upper energy thresholds in both scatter detectors are required in order to select mainly Compton events (one Compton interaction in each scatter detector and one interaction in the absorber detector). Then, we study the influence of various parameters such as the photon energy and the inter-detector distances on the Compton camera response. These studies are carried out by means of Geant4 simulations. We use a source with a spectrum corresponding to the prompt-γ spectrum emitted during the carbon ion irradiation of a water phantom. In the current configuration, the spatial resolution of the Compton camera is about 6 mm (Full Width at Half Maximum) and the detection efficiency 10-5. Finally, provided the detection efficiency is increased, the clinical applicability of our system is considered.

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The goal of this study is to tune the design of the absorber detector of a Compton camera for prompt γ-ray imaging during ion beam therapy. The response of the Compton camera to a photon point source with a realistic energy spectrum (corresponding to the prompt γ-ray spectrum emitted during the carbon irradiation of a water phantom) is studied by means of Geant4 simulations. Our Compton camera consists of a stack of 2 mm thick silicon strip detectors as a scatter detector and of a scintillator plate as an absorber detector. Four scintillators are considered: LYSO, NaI, LaBr3 and BGO. LYSO and BGO appear as the most suitable materials, due to their high photo-electric cross-sections, which leads to a high percentage of fully absorbed photons. Depth-of-interaction measurements are shown to have limited influence on the spatial resolution of the camera. In our case, the thickness which gives the best compromise between a high percentage of photons that are fully absorbed and a low parallax error is about 4 cm for the LYSO detector and 4.5 cm for the BGO detector. The influence of the width of the absorber detector on the spatial resolution is not very pronounced as long as it is lower than 30 cm.

Imaging During Ion Beam Therapy: A Monte Carlo Simulation Study

Longitudinal prompt-gamma ray profiles have been measured with a multi-slit multi-detector configuration at a 75 MeV/u 13C beam and with a PMMA target. Selections in time-of-flight and energy have been applied in order to discriminate prompt-gamma rays produced in the target from background events. The ion ranges which have been extracted from each individual detector module agree amongst each other and are consistent with theoretical expectations. In a separate dedicated experiment with 200 MeV/u 12C ions the fraction of inter-detector scattering has been determined to be on the 10%-level via a combination of experimental results and simulations. At the same experiment different collimator configurations have been tested and the shielding properties of tungsten and lead for prompt-gamma rays have been measured.

Design study of the absorber detector of a compton camera for on-line control in ion beam therapy

The Compton camera is a relevant imaging device for the detection of prompt photons produced by nuclear fragmentation in hadrontherapy. It may allow an improvement in detection efficiency compared to a standard gamma-camera but requires more sophisticated image reconstruction techniques. In this work, we simulate low statistics acquisitions from a point source having a broad energy spectrum compatible with hadrontherapy. We then reconstruct the image of the source with a recently developed filtered backprojection algorithm, a line-cone approach and an iterative List Mode Maximum Likelihood Expectation Maximization algorithm. Simulated data come from a Compton camera prototype designed for hadrontherapy online monitoring. Results indicate that the achievable resolution in directions parallel to the detector, that may include the beam direction, is compatible with the quality control requirements. With the prototype under study, the reconstructed image is elongated in the direction orthogonal to the detector. However this direction is of less interest in hadrontherapy where the first requirement is to determine the penetration depth of the beam in the patient. Additionally, the resolution may be recovered using a second camera.

Collimated prompt gamma TOF measurements with multi-slit multi-detector configurations

The Compton camera is an imaging device relevant for the detection of prompt photons produced during nuclear fragmentation in hadrontherapy. It allows a considerable improvement in detection compared to a standard gamma-camera but also requires more sophisticated image reconstruction techniques. In this work we apply a recently developed filtered backprojection algorithm to data simulated from a realistic Compton camera prototype designed for hadrontherapy on-line monitoring. We reconstruct images of a point source having a broad energy spectrum compatible with the up-mentioned application. Preliminary results indicate that the achievable resolution in directions parallel to the camera, thus including the beam direction, are compatible with the quality control requirements. With the prototype under study, the reconstructed image is elongated in the direction orthogonal to the camera. However this direction is of less interest and the resolution may be easily recovered using a second camera.

Low Statistics Reconstruction of the Compton Camera Point Spread Function in 3D Prompt-

Fig. 4. Reconstructed profi le in the case of protons (a) and carbon ions (b,c) with the time structure of the beam and realistic detector resolutions. The theoretical falloff position is 0 mm along the Y axis. For the fi gure 4a and 4b, the camera is centred on the Bragg peak position. In the fi gure 4c, the camera is shifted to 50 mm after the Bragg peak position. It shows that the maximum of the random coincidence distrubution is due to the position of the camera and not related to the falloff position. Therefore, we have to distinguish true coincidences which are the only way to get the falloff position. DEVELOPMENT OF A TIME-OF-FLIGHT COMPTON CAMERA FOR ONLINE CONTROL OF ION THERAPY