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M Jamei

University of Manchester

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Publication

Featured researches published by M Jamei.

Clin Phar Ther doi: 10.1038/clpt.2013.79 | 2013

A Physiologically –Based Pharmacokinetic Modelling Approach to Predict Disease-Drug Interactions: Suppression of CYP3A by IL-6.

K. Machavaram; Lisa M. Almond; Amin Rostami-Hochaghan; I. Gardner; M Jamei; S. Tay; S. Wong; A. Joshi; J.R Kenny

Archive | 2014

Framework, Organization and Applications of the Simcyp Population-Based Simulator to Support New Drug Development

M Jamei; Karen Yeo; Amin Rostami-Hodjegan

In: AAPS Transporter Workshop; 17 Mar 2013-19 Mar 2013; Bethesda, MD, USA. 2013. | 2013

An assessment of the OCT2/MATE transporter mediated DDI between metformin and cimetidine using a Mechanistic Kidney model (Mech KiM)

Amin Rostami-Hochaghan; Howard Burt; Sibylle Neuhoff; Lisa M. Almond; Lu Gaohua; M Jamei; Gt Tucker; A. Rowland-Yeo K Rostami-Hodjegan

Journal of Pharmacological and Toxicological Methods | 2016

An in silico PBPK-PD coupled approach to assess zolpidem effect on pre-clinically and clinically measured cardiac repolarisation parameters in the absence and presence of a circadian model of plasma ion concentration

Ben G. Small; M Jamei; Amin Rostami-Hodjegan; Sebastian Polak

In: The 24th Population Approach Group in Europe (PAGE) Meeting; 02 Jun 2015-05 Jun 2015; Hersonissos, Crete, Greece. 2015. | 2015

Towards more Realistic Clinical Trial Simulation: Establishing Inter-Correlations between Several Cytochrome P450 Enzyme Abundances in Human Liver

Janak Wedagedera; Khaled Abduljalil; Theresa Cain; Brahim Achour; Shriram M. Pathak; Mike Dunlavey; M Jamei; Amin Rostami-Hodjegan

Archive | 2013

Pharmacokinetics, Pharmacodynamics and Drug Transport and Metabolism Application of Permeability-Limited Physiologically-Based Pharmacokinetic Models: Part I-Digoxin Pharmacokinetics Incorporating P-Glycoprotein-Mediated Efflux

Sibylle Neuhoff; Karen Rowland Yeo; Zoe Barter; M Jamei; David B. Turner; Amin Rostami-Hodjegan; Sheffield S

In: Society of Toxicology Annual Meeting; San Antonio, USA. 2013. | 2013

Prediction of skin disposition after topical application of drugs – Simcyp platform as a tool for capturing system information and safety assessment

Amin Rostami-Hochaghan; Sebastian Polak; N Patel; M Jamei; Amin Rostami-Hodjegan

In: 2013 AAPS Annual Meeting and Exposition; 10 Nov 2013-14 Nov 2013; San Antonio, USA. 2013. | 2013

Prediction of QT changes in humans incorporating in vitro data into physiologically based cardiomyocyte cell model – a case study on inhibition of multiple cardiac ion currents by tolterodine and its metabolite

Amin Rostami-Hochaghan; N Patel; M Jamei; Amin Rostami-Hodjegan; Sebastian Polak

In: 2013 AAPS Annual Meeting and Exposition; 10 Nov 2013-14 Nov 2013; San Antonio, USA. 2013. | 2013

Prediction of Passive Regional Effective Intestinal Permeability in Mouse using ?MechPeff?: A Mechanistic Model utilizing only Drug Physiochemical Parameters as Inputs

Amin Rostami-Hochaghan; D Pade; Db Turner; M Jamei; Amin Rostami-Hodjegan

In: 2013 AAPS Annual Meeting and Exposition; 10 Nov 2013-14 Nov 2013; San Antonio, USA. 2013. | 2013

PBPK modeling of Negative Food Effects upon Oral Drug Absorption of the BCS Class III Drug Trospium Chloride (TC): Combination of a Dynamic Viscosity-Disintegration Model and the ADAM (Advanced Dissolution, Absorption and Metabolism

Amin Rostami-Hochaghan; Bo Liu; M Jamei; A. Turner Db. Rostami-Hodjegan

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Collaboration

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Amin Rostami-Hodjegan

University of Manchester

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Sebastian Polak

Jagiellonian University Medical College

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D Pade

Simcyp

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Khaled Abduljalil

Simcyp

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Lisa M. Almond

Simcyp

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Sibylle Neuhoff

Simcyp

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Adam S. Darwich

University of Manchester

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Brahim Achour

University of Manchester

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Darren M. Ashcroft

University of Manchester

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David B. Turner

Simcyp

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