M. Svehla

Morphometric and mechanical evaluation of titanium implant integration: Comparison of five surface structures

Achieving a stable bone-implant interface is an important factor in the long-term outcome of joint arthroplasty. In this study, we employed an ovine bicortical model to compare the bone-healing response to five different surfaces on titanium alloy implants: grit blasted (GB), grit blasted plus hydroxyapatite (50 microm thick) coating (GBHA), Porocoat(R) (PC), Porocoat(R) with HA (PCHA) and smooth (S). Push-out testing, histology, and backscatter scanning electron microscope (SEM) imaging were employed to assess the healing response at 4, 8, and 12 weeks. Push-out testing revealed PC and PCHA surfaces resulted in significantly greater mechanical fixation over all other implant types at all time points (p <.05). HA coating on the grit-blasted surface significantly improved fixation at 8 and 12 weeks (p <.05). The addition of HA onto the porous coating did not significantly improve fixation in this model. Quantification of ingrowth/ongrowth from SEM images revealed that HA coating of the grit-blasted surfaces resulted in significantly more ongrowth at 4 weeks (p <.05).

A resorbable porous ceramic composite bone graft substitute in a rabbit metaphyseal defect model.

The success of converted corals as a bone graft substitute relies on a complex sequence of events of vascular ingrowth, differentiation of osteoprogenitor cells, bone remodeling and graft resorption occurring together with host bone ingrowth into and onto the porous coralline microstructure or voids left behind during resorption. This study examined the resorption rates and bone infiltration into a family of resorbable porous ceramic placed bilaterally in critical sized defects in the tibial metaphyseal–diaphyseal of rabbits. The ceramics are made resorbable by partially converting the calcium carbonate of corals to form a hydroxyapatite (HA) layer on all surfaces. Attempts have been made to control the resorption rate of the implant by varying the HA thickness. New bone was observed at the periosteal and endosteal cortices, which flowed into the centre of the defect supporting the osteoconductive nature of partially converted corals. The combination of an HA layer and calcium carbonate core provides a composite bone graft substitute for new tissue integration. The HA‐calcium carbonate composite demonstrated an initial resorption of the inner calcium carbonate phase but the overall implant resorption and bone ingrowth behaviour did not differ with HA thickness.

The Effect of Screw Type on the Biomechanical Properties of SCARF and Crescentic Osteotomies of the First Metatarsal

The basilar crescentic osteotomy is a popular method for correcting moderate to severe hallux valgus. However, inadvertent dorsiflexion of the osteotomy can result from intraoperative malposition or from malunion after fixation failure. The mechanical properties of osteotomies are dependent on the nature of the osteotomy and the type of fixation. This study examines the mechanical properties of the SCARF and crescentic osteotomies of the first metatarsal by using a cannulated asymmetric pitched screw or AO cancellous screws. Sixteen human cadaveric first metatarsal specimens were tested in plantar to dorsiflexion cantilever bending by using a mechanical testing machine. The data was compared with our recent work on the mechanical properties of the SCARF and crescentic osteotomies. Ultimate load and stiffness of the SCARF osteotomy were superior to the crescentic osteotomy but were not dependent on screw type. Screw type was a prominent factor in the stiffness but not in the strength of the crescentic osteotomy. The ultimate load and the stiffness of SCARF osteotomy fixed with the cannulated asymmetric pitched screws were not significantly different compared with AO screws (ultimate load, 124.6 N [SD = 56.8] v 105.3 N [SD = 57.0]; stiffness, 52.0 N/mm [SD = 48.0] v 31.8 N/mm [SD = 19.0]). Modes of failure were fracture of the cortical bone bridge between the screw hole and the osteotomy in all crescentic osteotomies and fracture of the proximal dorsal bridge in all SCARF osteotomies. The superior mechanical properties of the SCARF osteotomy, fixed with cannulated asymmetric pitched screws, make this a more secure construct, with less risk of malunion than the crescentic osteotomy. Stiffness is an important mechanical factor that helps distinguish the mechanical performance of different osteotomy techniques.

Cell Structure and Biology of Bone and Cartilage

Bone and cartilage are highly specialized connective tissues that are engineered by nature to perform a variety of specialized tasks. As a result, these tissues have unique cellular constituents and ultrastructural organization that help optimize the biochemical demands and biomechanical loads in vivo. Our understanding of these connective tissues has increased over the past few centuries, and progress continues as techniques are defined and improved or new ones are developed. The understanding of the ultrastructural and mechanical properties of bone and cartilage is a dynamic area that is constantly evolving with new understanding. This chapter departs from traditional overviews of bone and cartilage, and presents an examination of cellular constituents and ultrastructural organization of these tissues in the context of recent experimental and theoretical studies. It is the hope of the authors to bring to light many new and exciting findings.