Macklin Brian Arnold | Researchain

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Featured researches published by Macklin Brian Arnold.

Journal of Medicinal Chemistry | 1998

Synthesis and evaluation of a series of novel 2-[(4-chlorophenoxy)methyl]-benzimidazoles as selective neuropeptide Y Y1 receptor antagonists

Hamideh Zarrinmayeh; Anne Marie Nunes; Paul L. Ornstein; Dennis M. Zimmerman; Macklin Brian Arnold; Douglas A. Schober; Susan L. Gackenheimer; Robert F. Bruns; Philip Arthur Hipskind; Thomas C. Britton; Buddy E. Cantrell; Donald R. Gehlert

Journal of Medicinal Chemistry | 1993

(3SR,4aRS,6RS,8aRS)-6-[2-(1H-tetrazol-5-yl)ethyl]decahydroisoquinoline-3-carboxylic acid : a structurally novel, systemically active, competitive AMPA receptor antagonist

Paul L. Ornstein; Macklin Brian Arnold; Nancy K. Augenstein; David Lodge; Leander Jd; Darryle D. Schoepp

Journal of Medicinal Chemistry | 1998

2-Substituted (2SR)-2-Amino-2-((1SR,2SR)-2-carboxycycloprop-1-yl)glycines as Potent and Selective Antagonists of Group II Metabotropic Glutamate Receptors. 2. Effects of Aromatic Substitution, Pharmacological Characterization, and Bioavailability

Paul L. Ornstein; Thomas John Bleisch; Macklin Brian Arnold; Jh Kennedy; Rebecca A. Wright; Bryan G. Johnson; Joseph P. Tizzano; Helton; Darryle D. Schoepp; M. Herin

Journal of Medicinal Chemistry | 1991

4-(Tetrazolylalkyl)piperidine-2-carboxylic acids. Potent and selective N-methyl-D-aspartic acid receptor antagonists with a short duration of action.

Paul L. Ornstein; Darryle D. Schoepp; Macklin Brian Arnold; Leander Jd; David Lodge; Jonathan W. Paschal; T. Elzey

Journal of Medicinal Chemistry | 2000

Biarylpropylsulfonamides as novel, potent potentiators of 2-amino-3-(5-methyl-3-hydroxyisoxazol-4-yl)-propanoic acid (AMPA) receptors

Paul L. Ornstein; Dennis M. Zimmerman; Macklin Brian Arnold; Thomas John Bleisch; Buddy E. Cantrell; Richard Lee Simon; Hamideh Zarrinmayeh; Baker; Mary Gates; Joseph P. Tizzano; David Bleakman; Allan Mandelzys; Keith R. Jarvie; Ken Ho; Deverill M; Rajender Kamboj

Journal of Medicinal Chemistry | 1998

2-Substituted (2SR)-2-Amino-2-((1SR,2SR)-2-carboxycycloprop-1-yl)glycines as Potent and Selective Antagonists of Group II Metabotropic Glutamate Receptors. 1. Effects of Alkyl, Arylalkyl, and Diarylalkyl Substitution

Paul L. Ornstein; Thomas John Bleisch; Macklin Brian Arnold; Rebecca A. Wright; Bryan G. Johnson; Darryle D. Schoepp

Archive | 2007

NOVEL MCH RECEPTOR ANTAGONISTS

Macklin Brian Arnold; Yen Dao; Kevin Matthew Gardinier; David Joseph Garmene; Steven J. Green; Erik James Hembre; Jianliang Lu

Archive | 2009

Inhibitors of diacylglycerol acyltransferase

Macklin Brian Arnold; Thomas James Beauchamp; Emily J. Canada; Erik James Hembre; Jianliang Lu; John Robert Rizzo; John Mehnert Schaus; Qing Shi

Journal of Medicinal Chemistry | 1996

Structure-activity studies of 6-(tetrazolylalkyl)-substituted decahydroisoquinoline-3-carboxylic acid AMPA receptor antagonists. 1. Effects of stereochemistry, chain length, and chain substitution

Paul L. Ornstein; Macklin Brian Arnold; Nancy K. Allen; Thomas John Bleisch; Borromeo Ps; Charles Willis Lugar; Leander Jd; David Lodge; Darryle D. Schoepp

Archive | 1999