Mahadevan Bhupathy

A NOVEL SYNTHESIS OF DISUBSTITUTED UREAS USING TITANIUM(IV) ISOPROPOXIDE AND SODIUM BOROHYDRIDE

This paper describes a high yield preparation of unsymmetrically disubstituted ureas by a titanium(IV) isopropoxide/sodium borohydride mediated reductive amidation of aromatic aldehydes with monosubstituted ureas.

The enantioselective synthesis of LTD4 antagonist L-708,738

Abstract An efficient, 9-step synthesis of LTD 4 antagonist L-708,738 is described. The asymmetric center is set via a chiral borane reduction.

A convergent synthesis of a novel non-peptidyl growth hormone secretagogue, L-692,429

Abstract A practical, convergent synthesis of L-692,429 (1) from three key intermediates - the 3- aminobenzlactam 2, the β-lactam 3 and the biphenyltetrazole 4 is described. The mechanism of the coupling reaction in which 3 is used as a β-aminoacid equivalent is also presented.