Mahima Sharma

Antidiabetic and antioxidant potential of β-sitosterol in streptozotocin-induced experimental hyperglycemia.

Background:  Oxidative stress, produced under diabetic conditions, may cause tissue damage. Although several drugs are currently available for the treatment of diabetes, their continued use may cause unwanted side effects. The aim of the present study was to evaluate the antioxidant potential of β‐sitosterol (BS), a phytosterol from Solanum surattense, using an experimental model for diabetes‐induced oxidative damage.

Evaluation of antidiabetic and antioxidant potential of lupeol in experimental hyperglycaemia.

Oxidative stress, produced under diabetic conditions, is a possible cause of various forms of tissue damage. The concentrations of antioxidant enzymes in cases of diabetes are significantly decreased, with a concomitant increase in lipid peroxidation. In this study, lupeol, a phytoconstituent from Solanum xanthocarpum, is shown to suppress the progression of diabetes after 21 days. Lupeol treatment caused decreases in glycated haemoglobin, serum glucose and nitric oxide, with a concomitant increase in serum insulin level. Furthermore, treatment with lupeol also increased antioxidant levels, with a decrease in the level of thiobarbituric acid-reactive oxygen species.

Phytochemical evaluation and antispermatogenic activity of Thevetia peruviana methanol extract in male albino rats

This study was conducted to evaluate the antifertility potential of Thevetia peruviana (Apocynaceae) in male albino rats with their phytochemical evaluations. Phytochemical examination showed that plant is rich in active constituents, i.e. α-amyrin acetate, lupeol acetate, α-amyrin, β-amyrin, lupeol and thevetigenin. T. peruviana stem bark methanol extract (TPMtE) administered orally to male rats at the dose level of 100 mg/rat/day did not cause any significant reduction in body weight, while the weight of reproductive organs reduced significantly. A significant fall in the total protein and sialic acid content of the testes, epididymides, seminal vesicle and ventral prostate, as well as in the glycogen content of testes was also observed; however, cholesterol was increased significantly. TPMtE also caused a decline in spermatogenic elements, i.e. preleptotene and pachytene spermatocytes, secondary spermatocytes, round spermatids and mature Leydig cells. At this dose level Leydig cell nuclear diameter, seminiferous tubular diameter and Sertoli area were significantly reduced (p < 0.001). The reduction in sperm density and motility resulted in 18% residual fertility. In conclusion, T. peruviana inhibited spermatogenesis in rats, indicating the possibility of developing a herbal male contraceptive.

Future aspirations of undergraduate medical students at Government Medical College, Ajmer (Rajasthan)

Background: Distribution of available manpower in healthcare sector is an important issue to maintain the optimum health status of the community. The study of aspirations of the undergraduate medical students might help to know the future availability of the medical fraternity in various fields and to understand the necessities in the medical education field in Rajasthan State. Methods: A cross-sectional study was conducted among 500 undergraduate medical students of JLN Medical College, Ajmer (Rajasthan) in November 2015, using a self-administered questionnaire. Results: There were 65% males and 35% females. About 41.88% students were from rural and 58.12% were from urban background. Average age of students was 21.23 years (±1.89). Majority (87.92%) of MBBS students aspired to do postgraduation. Only 14.17% were interested in a government job in rural and 28.54% in urban areas. Very few (2.7%) students were interested in the research field. Approximately, 8% students wanted to study abroad. Overall specialty preference was internal medicine (31.45%), surgery (15.95%), and Pediatrics (12.07%). Branch preference in females was the same. Nonclinical branches were not the preferred choice among our study participants. The most influencing factors for undergraduate students to choose specialty were job satisfaction and job security (>90%). Unnecessary burden of complicated clerical work instead of clinical job (80.83%) was an important influencing factor for less interest in a government job. Conclusions: Our study shows majority of students desiring to do postgraduation in clinical specialties and most of them want to join urban, socially respectful clinically oriented hospitals instead of a primary health center at the rural area or a nonclinical research oriented specialty. It might lead to shortage of doctors in non- and para-clinical branches and also in rural areas of Rajasthan in future.

Primary intracranial multiple hydatid cysts in an adult

Cerebral hydatid disease is an uncommon presentation of echinococcosis representing 1-2% of all Echinococcus granulosus infestations. Most of the cases are seen in children. Primary multiple hydatid disease of the brain in adults is a rare entity. We report here a case of 35-year-old male with primary cerebral hydatid disease without extracranial lesions.

Diabetic Foot Ulcers: A Prospective Study Of 100 Patients Based On Wound Based Severity Score.

The Diabetic foot is the commonest complication of Diabetes and is a leading cause of Hospitalization and prolonged in - patient treatment. Diabetic foot ulcer is far and away the most frequent indication for non traumatic lower limb amputations. Appropriate preventive measures as well as patient education will markedly reduce ulcer formation and the frequency of amputations in addition to cutting down on healthcare costs. Here we studied 100 diabetic patients on the basis of new wound based severity scoring system given by Beckert et al. AIMS & OBJECTIVES