Maja Cindrić

Synthesis, antioxidative and antiproliferative activity of methoxy amidino substituted benzamides and benzimidazoles

Within this manuscript the synthesis and potential antioxidative and antiproliferative activity of novel methoxy amidino substituted bezamides 6–17 and benzimidazoles 23–28 and 32–35 is presented. Their antioxidative potency has been evaluated by in vitro spectrophotometric assays and preliminary structure–activity relationships among the synthesized compounds are discussed. The compound 28 bearing three methoxy groups on a phenyl ring and imidazolinyl amidine group on benzimidazole nuclei directly attached to the phenyl ring exhibited the most prominent reducing activity as well as free-radical scavenging activity. Furthermore all novel compounds were tested against three human cell lines: HCT 116 (colon carcinoma), H 460 (lung carcinoma) and MCF-7 (breast carcinoma). The most prominent antiproliferative effect in the single-digit micromolar range was observed for compound 33 on MCF-7 (IC50 = 9 µM) cell line, comparable to the standard etoposide.

Antibacterial and antiproliferative activity of novel 2-benzimidazolyl- and 2-benzothiazolyl-substituted benzo[b]thieno-2-carboxamides

Novel nitro (3a–3f)- and amino (4a–4f and 5a–5f)-substituted 2-benzimidazolyl and 2-benzothiazolyl benzo[b]thieno-2-carboxamides were designed and synthesized as potential antibacterial agents. The antibacterial activity of these compounds has been evaluated against Gram-positive (Staphylococcus aureus and Enterococcus faecalis) and Gram-negative bacteria (Escherichia coli and Moraxella catarrhalis). The most promising antibacterial activity was observed for the nitro- and amino-substituted benzimidazole derivatives 3a, 4a, 5a and 5b with MICs 2–8

Novel amidino substituted benzimidazole and benzothiazole benzo[b]thieno-2-carboxamides exert strong antiproliferative and DNA binding properties

\upmu \hbox {g/mL}

Chemical Composition, Antioxidant and Antibacterial Activity of Different Extracts of Poplar Type Propolis

μg/mL. Additionally, compounds with inferior antibacterial activity were further tested for their antiproliferative activity in vitro against three human cancer cell lines. Amino-substituted benzothiazole hydrochloride salt 5d displayed the most pronounced and selective activity against the MCF-7 cell line with an

Synthesis and antioxidative potency of novel amidino substituted benzimidazole and benzothiazole derivatives

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Antibacterial and antiproliferative activity of novel 2-benzimidazolyl and 2-benzothiazolyl substitued benzo[b]thieno-2-carboxamides

IC50 of 40 nM. Furthermore, DNA binding experiments of selected derivatives indicated that DNA cannot be considered as a primary biological target for this type of compounds.Graphical Abstract