Mandip Goyal

Pharmacognostical and Preliminary physicochemical evaluation of Triphaladi granules - A polyherbal Ayurvedic formulation

Triphaladi Kwatha , a polyherbal Ayurvedic formulation, is recommended by Chakradatta and Yogaratnakara in the management of Prameha which has resemblance with type 2 diabetes mellitus. The present study deals with development of pharmacognostical and preliminary pharmaceutical profile of Triphaladi granules. The pH (5% aqueous extract) was 6.0, water-soluble extract 48.66% w/w, alcohol-soluble extract 33.91% w/w, ash value 5.97% w/w, and loss on drying at 105°C was 6.53% w/w. High performance thin layer chromatography were carried out after organizing appropriate solvent system in which maximum nine spots were distinguished and few of the R f values were identical in the alcoholic extract.

A clinical study on the role of Agnimanthadi compound and Vashpa Svedana in the management of Sthaulya (obesity)

Currently more than 1 billion adults are overweight (Sthula) and at least 300 million of them are clinically obese. Obesity leads to adverse metabolic effects on blood pressure, cholesterol, triglycerides, and insulin resistance. Present study was planned to assess the role of Agnimanthadi compound containing Agnimantha, Mustaka, Gomutra (cow′s urine), and Eranda Patra Kshara and Vashpa Svedana (VS) (generalized steaming) in the management of obesity. 80 patients of Sthaulya (obesity) were selected out of which 67 completed the treatment and they were treated in two groups. Amongst these, 38 patients were treated with Agnimanthadi compound in the dose of 2 gram (four capsules of 500 mg) 3 times a day with lukewarm water before meal and remaining 29 patients were given VS only. The duration of treatment in both groups was 7 weeks with follow-up for 2 months after the completion of treatment. Analysis of the overall effects of both the groups showed that VS provided marked reduction in weight, body mass index, and other signs and symptoms in patients of Sthaulya in comparison to the Agnimanthadi treated group.

A PILOT STUDY ON QUASSIA AMARA LINN.: A NEWLY EMERGING DRUG FOR TYPE 2 DIABETES

Though the awareness about Health in community is raising, changes in dietary habits and lifestyle of people from all age groups has resulted emergence of various non communicable diseases. Among these non communicable diseases diabetes tops the list and has overtaken communicable diseases with respect to overall mortality, even in developing countries like India. Quassia amara Linn. an ethno medicinal plant finds no direct reference in Ayurvedic classics, Quassin constituent of Quassia amra in it is one of the bitterest substances found in nature. The bitters plants are generally showing anti-diabetic and tonic action. For this clinical study, 58 cases of recently diagnosed, mild to moderate cases of type 2 diabetes were administered capsules filled with heartwood powder of Quassia amara Linn., 3 capsules (500mg each) twice daily before food with lukewarm water along with controlled diet for 60 days. To assess the effect of trial drug fasting Blood sugar, post parandial blood sugar, lipid profile and BMI were done before and after the completion of 60 days of the treatment. It was observed that treatment with cap. Quassia amara provided statistically highly significant reduction of 19.33% in fasting blood sugar level and of 22.05% in Post Prandial Blood Sugar levels. Similarly, significant decrease of 9.95% in serum Cholesterol level and that of 13.63 % in S. Triglyceride level and 1.52% decrease in BMI was found. It showed the potential of Quassia amara Linn. heartwood powder as single herb therapy in patients of type 2 diabetes.

AN OPEN LABELED, RANDOMIZED, PARALLEL ARMS, CLINICAL TRIAL TO EVALUATE SEDATIVE EFFECT OF LEAVES OF BEEJAPURA (CITRUS MEDICA LINN.) AND RHIZOME OF JATAMANSI (NARDOSTACHYS GRANDIFLORA) IN ANIDRA (PRIMARY INSOMNIA)

Primary insomnia is a major health issue with a bearing on the morbidity, health related quality of life. Pharmacologic treatment for insomnia has been shown to be associated with significant side effects; hence, it is need to search safe and effective remedies from natural sources. Powder of Beejapura (Citrus medica Linn) leaves with honey has been indicated to induce sleep in classical text of Ayurveda. Keeping this in view, open labelled, randomised parallel arm clinical trial was planned to evaluate the efficacy of the leaves powder of Citrus medica Linn. on primary insomnia in comparison to Jatamansi (rhizome of Nardostrachys grandiflora DC). Patients of primary insomnia belonging to age group of 20-70 years were diagnosed on the basis of diagnostic criteria given for insomnia in DSM – IV-TR. Total 66 patients were registered and randomly allocated in two arms, among them, total 62 completed the trials. Statistically, 30.6% overall effect was provided by Beejapura leaves, whereas 55.6% overall effect was provided by Jatamansi rhizome in the signs and symptoms of Primary insomnia. The difference between both therapies was statistically significant (p<0.001) wherein Jatamansi rhizome produced clinically better result in comparison to Beejapura leaves. Data indicates that Beejapura leaves improved only late sleep induction whereas Jatamansi rhizome provided better improvement in terms of late sleep induction and sleep maintenance.

ROLE OF ASHVATHA PHALA CHURNA AND SHVETA PALANDU SVARASA BHAVITA YAVANI IN THE MANAGEMENT OF KSHEENA SHUKRA (OLIGOZOOSPERMIA) AFTER SHODHANA THERAPY - CLINICAL STUDY.

Jitendra Varsakiya 1 and Mandip Goyal 2 . 1. Ph.D Scholar, Department of Kayachikitsa, I.P.G.T & RA, Gujarat Ayurved University, Jamnagar, Gujarat, India. 2. Associate Professor, Department of Kayachikitsa, IPGT & RA, Gujarat Ayurved University, Jamnagar, Gujarat, India. ...................................................................................................................... Manuscript Info Abstract ......................... ........................................................................ Manuscript History

Role of Virechana and Ashwatha Phala Churna in the management of Ksheena Shukra (oligozoospermia): A pilot study

Background: Infertility is the inability of a sexually active, noncontracepting couple to achieve spontaneous pregnancy in 1 year. Low sperm count (oligozoospermia) is one of the main causes of male infertility and is correlated with Ksheena Shukra (oligozoospermia). Shodhana procedures are to be performed before the administration of Vajikarana drugs, especially Virechana karma has been indicated in the cases of Shukra Dushti. The fruit of Ashwatha (Ficus religiosa Linn.) has been indicated in premature ejaculation and low sperm count. Aim: This study aimed to evaluate the effect of Virechana and Ashwatha Phala Churna in the management of Ksheena Shukra (oligozoospermia). Materials and Methods: Eligible male participants between the age of 21 and 50 years, with sperm count < 15 million/ml, received Ashwatha Phala Churna for 60 days in the dose of 3 g, after undergoing Virechana Karma. The primary outcomes measured were percentage changes in the seminal parameters and associated symptoms of Ksheena Shukra in comparison to baseline. Results: The Ashwatha Phala Churna administered after Virechana provided 59.78* increase in sperm count, 36.81* increase in semen volume, and 16.18* decrease in abnormal form of sperm and 91.34* of increase was reported in total sperm count after Virechana Karma which was also statistically significant. Conclusion: Overall assessment of the therapy showed that administration of Ashwatha Phala Churna after performing Virechana provided statistically significant improvement on seminal parameters, especially total sperm count.

Hypoglycemic and anti-hyperglycemic activity of Triphalādi granules in mice

Background: Triphalādi kvātha is well known herbal Ayurvedic formulation used in Prameha (~type 2 diabetes mellitus). In the present study, kvātha was converted into granules and assessed for its hypoglycemic and anti-hyperglycemic effects in albino mice. Materials and Methods: Triphalādi granules (650 mg/kg, p.o.) were administered in normal albino mice for assessment of hypoglycemic activity. Anti-hyperglycemic activity of Triphalādi granules was assessed in glucose (5 g/kg, p.o.) solution overloaded mice. The blood sugar level (BSL) was measured with the help of one touch easy glucometer. Results: Triphalādi granules produced significant decrease in blood glucose level after one hour in comparison to initial values while decreasing BSL by 27.92% in comparison to control group in normal albino mice. In hyperglycemic study, Triphalādi granules produced significant decrease the BSL after 2 hr. of administration compared to control group. Conclusion: Triphalādi granules have significant hypoglycemic and anti-hyperglycemic activity in mice with minimal effect on BSL below normal range. The studies suggest the potential role of Triphalādi granules as an alternative adjuvant therapy in diabetic individuals for the control of the blood glucose level.

PHA R MACOGNOSTICAL AND PH AR MAC EU TICAL EVALUATION OF SHVETA PALANDU SWARASA BHAVITA YAVANI VATI

Infertility is defined as the failure to achieve a pregnancy within one year of regular (at least three times per month) unpr otected intercourse. Oligozoospermia i.e. sperm count less than 15 million /ml is one of the causes for infertility. According to various research conducted by Carlsan et al , between 1938 to 1988; it is relevant that sperm count, has come down from 130 million/ml of semen to 66 million/ml of semen . Now a day’s o ligozoospermia and infertility are common problems due to disturb daily routine, disturb food habits and mental stress on account of fast life. Shveta Palandu is Vrishya and has been reported to have Aphrodisiac, anti - bac terial, tonic, carminative , propertie s. Tilld ate no clinical trial and pharmaceutical analysis of Shveta Palandu Swarasa Bhavita Yavani Vati has been carried out , hence in the present study Shveta Palandu Swarasa Bhavita Yavani Vati was subject ed to pharma cognostical and p harmaceutical analysis. Phar macognostical evaluation showed presence of e pidermal cells and fibers of Palandu and Stone cells of Yavani . Pharmaceuti cal evaluation showed loss on drying 13 % w/w, p H 5.5 . HPTLC results showed 6 spots at 254 nm and 8 spots at 366 nm.

OA01.29. Evaluation of parasikayavanyadi capsule in the management of anidra w.s.r. to insomnia

Purpose: Insomnia is a sleeping disorder characterised by persistent difficulty in falling asleep or staying asleep despite the opportunity. It is one of the burning problems all over the world. Statistics shows that 20% - 40% adults encounter insomnia problems during a year time. Allopathic hypnotic drugs are useful for short term treatment in Insomnia which is due to acute stage. Long term uses of certain classes of sedatives cause physical dependence and withdrawal symptoms also have a number of side effects. In the present era, patient prefers readymade, cost effective, easily palatable drugs with fewer side effects for their health problems. For the present clinical trial, Parsikayavanyadi Capsule consisting of Parasikayavani, Jatamamsimoola, triturated with juice of Sankhpushpi and Kushmanda, was formulated to evaluate its efficacy in the management of insomnia Method: Total 32 patients of newly diagnosed case of insomnia who were randomly divided in to two groups. In Group P.V (Parasikayavanyadi group), 20 patients were administered 5 capsules of Pariskvayanadi Churna of 500 mg each with a cup of warm milk at bed time for one month. In Group P.C (Placebo group), 12 patients were given Starch Capsules of 500 mg each with same Anupana and duration. Assessment was done considering the overall improvement of insomnia according to Pittsburgh insomnia rating Scale, improvement of associated complains of insomnia, relieving of negative emotions, improving of positive emotions, relieving of level of anxiety according to Hamilton Anxiety Rating Scale and relieving of level of depression according to Hamilton Depression Rating scale before and after one month of treatment period. Result: parasikayavanyadi capsule provided significant effect in the management of insomnia. Conclusion: The study has revealed that parasikayavanyadi capsule provided significant effect in the management of insomnia in comparison to placebo.