Manoj Patel | Researchain

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Featured researches published by Manoj Patel.

Bioorganic & Medicinal Chemistry Letters | 2015

Synthesis and evaluation of C2-carbon-linked heterocyclic-5-hydroxy-6-oxo-dihydropyrimidine-4-carboxamides as HIV-1 integrase inhibitors

B. Narasimhulu Naidu; Margaret E. Sorenson; Manoj Patel; Yasutsugu Ueda; Jacques Banville; Francis Beaulieu; Sagarika Bollini; Ira B. Dicker; Helen Higley; Zeyu Lin; Lori Pajor; Dawn D. Parker; Brian Terry; Ming Zheng; Alain Martel; Nicholas A. Meanwell; Mark Krystal; Michael A. Walker

Integration of viral DNA into the host cell genome is an obligatory process for successful replication of HIV-1. Integrase catalyzes the insertion of viral DNA into the target DNA and is a validated target for drug discovery. Herein, we report the synthesis, antiviral activity and pharmacokinetic profiles of several C2-carbon-linked heterocyclic pyrimidinone-4-carboxamides that inhibit the strand transfer step of the integration process.

Archive | 2009

Bridged heterocycles as hiv integrase inhibitors

Francis Beaulieu; Carl Ouellet; B. Narasimhulu Naidu; Manoj Patel; Yasutsugu Ueda; Timothy P. Connolly; Jonathan R. Weiss; Michael A. Walker; Nicholas A. Meanwell; Kevin Peese; Margaret E. Sorenson

Archive | 2015

PYRIDIN-3-YL ACETIC ACID DERIVATIVES AS INHIBITORS OF HUMAN IMMUNODEFICIENCY VIRUS REPLICATION

B. Narasimhulu Naidu; Manoj Patel; Jeffrey L. Romine; R Laurent Denis; Tao Wang; Zhongxing Zhang; John F. Kadow

Archive | 2015

PYRAZOLOPYRIMIDINE MACROCYCLES AS INHIBITORS OF HUMAN IMMUNODEFICIENCY VIRUS REPLICATION

B. Narasimhulu Naidu; Michael A. Walker; Margaret E. Sorenson; Manoj Patel; Zhizhen Barbara Zheng; John F. Kadow; Bin Zheng; Martin D. Eastgate; Ke Chen; Francisco González-Bobes

Archive | 2017

Inhibidores de la replicación del virus de la inmunodeficiencia humana

B. Narasimhulu Naidu; Manoj Patel; Stanley D'andrea; Zhizhen Barbara Zheng; Timothy P. Connolly; David R. Langley; Kevin Peese; Zhongyu Wang; Michael A. Walker; John F. Kadow

Archive | 2016

DERIVADOS DEL ÁCIDO PIRIDIN-3-ILACÉTICO COMO INHIBIDORES DE LA REPLICACIÓN DEL VIRUS DE INMUNODEFICIENCIA HUMANA

John F. Kadow; Zhongxing Zhang; Tao Wang; Denis R. St. Laurent; Jeffrey L. Romine; Manoj Patel; B. Narasimhulu Naidu

Archive | 2016

MACROCICLOS DE PIRAZOLOPIRIMIDINA COMO INHIBIDORES DE LA REPLICACIÓN DEL VIRUS DE LA INMUNODEFICIENCIA HUMANA

Francisco González-Bobes; Ke Chen; Martin D. Eastgate; Bin Zheng; John F. Kadow; Zhizhen Barbara Zheng; Manoj Patel; Margaret E. Sorenson; Michael A. Walker; B. Narasimhulu Naidu

Archive | 2016