Network


Latest external collaboration on country level. Dive into details by clicking on the dots.

Hotspot


Dive into the research topics where Maobin Yang is active.

Publication


Featured researches published by Maobin Yang.


Current Stem Cell Research & Therapy | 2014

Advances of Mesenchymal Stem Cells Derived from Bone Marrow and Dental Tissue in Craniofacial Tissue Engineering

Maobin Yang; Hongming Zhang; Riddhi Gangolli

Bone and dental tissues in craniofacial region work as an important aesthetic and functional unit. Reconstruction of craniofacial tissue defects is highly expected to ensure patients to maintain good quality of life. Tissue engineering and regenerative medicine have been developed in the last two decades, and been advanced with the stem cell technology. Bone marrow derived mesenchymal stem cells are one of the most extensively studied post-natal stem cell population, and are widely utilized in cell-based therapy. Dental tissue derived mesenchymal stem cells are a relatively new stem cell population that isolated from various dental tissues. These cells can undergo multilineage differentiation including osteogenic and odontogenic differentiation, thus provide an alternative source of mesenchymal stem cells for tissue engineering. In this review, we discuss the important issues in mesenchymal stem cell biology including the origin and functions of mesenchymal stem cells, compare the properties of these two types of mesenchymal cells, update recent basic research and clinic applications in this field, and address important future challenges.


Bone | 2010

Col3.6-HSD2 transgenic mice: A glucocorticoid loss-of-function model spanning early and late osteoblast differentiation

Maobin Yang; Lorin B. Trettel; Douglas J. Adams; John R. Harrison; Ernesto Canalis; Barbara E. Kream

The goal of this study was to characterize the bone phenotype and molecular alterations in Col3.6-HSD2 mice in which a 3.6-kb Col1a1 promoter fragment drives 11beta-HSD2 expression broadly in the osteoblast lineage to reduce glucocorticoid signaling. Serum corticosterone was unchanged in transgenic females excluding a systemic effect of the transgene. Adult transgenic mice showed reduced vertebral trabecular bone volume and reduced femoral and tibial sub-periosteal and sub-endosteal areas as assessed by microCT. In adult female transgenic mice, histomorphometry showed that vertebral bone mass and trabecular number were reduced but that osteoblast and osteoclast numbers and the mineral apposition and bone formation rates were not changed, suggesting a possible developmental defect in the formation of trabeculae. In a small sample of male mice, osteoblast number and percent osteoid surface were increased but the mineral apposition bone formation rates were not changed, indicating subtle sex-specific phenotypic differences in Col3.6-HSD2 bone. Serum from transgenic mice had decreased levels of the C-terminal telopeptide of alpha1(I) collagen but increased levels of osteocalcin. Transgenic calvarial osteoblast and bone marrow stromal cultures showed decreased alkaline phosphatase and mineral staining, reduced levels of Col1a1, bone sialoprotein and osteocalcin mRNA expression, and decreased cell growth and proliferation. Transgenic bone marrow cultures treated with RANKL and M-CSF showed greater osteoclast formation; however, osteoclast activity as assessed by resorption of a calcium phosphate substrate was decreased in transgenic cultures. Gene profiling of cultured calvarial osteoblasts enriched in the Col3.6-HSD2 transgene showed modest but significant changes in gene expression, particularly in cell cycle and integrin genes. In summary, Col3.6-HSD2 mice showed a low bone mass phenotype, with decreased ex vivo osteogenesis. These data further strengthen the concept that endogenous glucocorticoid signaling is required for optimal bone mass acquisition and highlight the complexities of glucocorticoid signaling in bone cell lineages.


Endocrine | 2008

Calcitonin induces expression of the inducible cAMP early repressor in osteoclasts.

Maobin Yang; Barbara E. Kream

The cAMP response element modulator gene (Crem) encodes a variety of transcriptional regulators including the inducible cAMP early repressor, ICER. We previously showed that Crem knockout mice, which are deficient in CREM and ICER factors, display slightly increased long bone mass and decreased osteoclast number. These data are consistent with the notion that Crem regulates bone mass in part through an effect on osteoclast formation and/or function. Since ICER is strongly induced by cAMP, we asked whether the calcium-regulating hormone calcitonin, which stimulates cAMP production and inhibits osteoclastic bone resorption, could induce ICER in osteoclasts. The monocytic cell line RAW264.7 was treated with receptor activator of NF-κB ligand (RANKL) to induce osteoclast formation. Calcitonin caused a time- and dose-dependent induction of ICER mRNA and an increase in ICER protein abundance in RANKL-treated RAW264.7 cells. Calcitonin also induced ICER mRNA and protein in osteoclasts derived from primary mouse bone marrow cell cultures. Calcitonin-treated osteoclasts showed immunoreactivity with an anti-CREM antibody. Calcitonin decreased the activity of wild-type and Crem knockout osteoclasts in vitro, and this inhibitory effect was greater in Crem knockout osteoclasts. Furthermore, calcitonin decreased calcitonin receptor mRNA expression in wild-type osteoclasts, but not in Crem knockout osteoclasts. These data suggest that calcitonin induction of ICER in osteoclasts might regulate osteoclast activity.


Journal of Endodontics | 2017

Regenerative Endodontics Versus Apexification in Immature Permanent Teeth with Apical Periodontitis: A Prospective Randomized Controlled Study

Jiacheng Lin; Qian Zeng; Xi Wei; Wei Zhao; Minyi Cui; Jing Gu; Jiaxuan Lu; Maobin Yang; Junqi Ling

Introduction The aim of the study was to compare the outcomes of regenerative endodontic treatment (RET) and apexification on immature permanent teeth with pulp necrosis and apical periodontitis. Methods A total of 118 patients (118 teeth) were recruited and randomly assigned to either RET or apexification treatment. Each treatment group was divided into 2 subgroups according to the etiology: dens evaginatus or trauma. Clinical symptoms and complications were recorded, and cone‐beam computed tomographic imaging with a limited field of view was used to measure the change of root length, root thickness, and apical foramen size at the 12‐month follow‐up. The t test/rank sum test and Fisher exact test were applied to compare the change of root morphology between RET and apexification. Results One hundred three of 118 cases were completed at the 12‐month follow‐up. The survival rate was 100% for both treatment groups. All cases were asymptomatic with apical healing. The RET group showed a significant increase in root length and root thickness compared with the apexification group (P < .05). In the RET group, the cases caused by dens evaginatus achieved increased root length and root thickness compared with those caused by trauma (P < .05). Conclusions RET and apexification achieved a comparable outcome in regard to the resolution of symptoms and apical healing. RET showed a better outcome than apexification regarding increased root thickness and root length. The etiology had an impact on the outcome of RET. Dens evaginatus cases showed better prognoses than trauma cases after RET.


Archive | 2018

A Bilayered Scaffold Provides Differential Cues for the Differentiation of Dental Pulp Stem Cells

Riddhi A. Gangolli; Sean M. Devlin; Jonathan A. Gerstenhaber; Peter I. Lelkes; Maobin Yang

IMPACT STATEMENT In this article we used an FDA-approved biodegradable biomaterial, poly (lactic-co-glycolic acid) (PLGA 75:25) to generate a bilayered scaffold with the capacity to induce differential, layer-specific dentinogenic differentiation of dental pulp stem cells (DPSCs) in vitro. We surmise that such a scaffold can be used in conjunction with current regenerative endodontic procedures to help regenerating a physiologic dentin-pulp complex in vivo. We hypothesize that our scaffold in conjunction with DPSCs will advance current regenerative endodontics by restoring dentin and initiating the innervation and revascularization of the pulp.


Journal of Endodontics | 2016

Release of Growth Factors into Root Canal by Irrigations in Regenerative Endodontics

Qian Zeng; Sean Nguyen; Hongming Zhang; Hari Priya Chebrolu; Dalia Alzebdeh; Mustafa A. Badi; Jong Ryul Kim; Junqi Ling; Maobin Yang


Archive | 2013

Regenerative Endodontics: A New Treatment Modality for Pulp Regeneration

Maobin Yang


Current Stem Cell Research & Therapy | 2017

Application of Hydrogels in Cartilage Tissue Engineering

Ximu Zhang; Wei Zhang; Maobin Yang


Archive | 2016

Mesenchymal Stem Cells and Craniofacial Regeneration

Jing Wang; YunFeng Lin; Jing Chen; Zhaozhao Chen; Shuwen Deng; N. Fu; K. Huang; Renhuan Huang; Qing Huang; Fan Jian; Guo Li; Yan Li; S. Lin; Y. Lin; L. Liu; Y. Liu; L. Lu; Y. Lu; Runyi Mao; B. Olsson; S. Qi; X. Shao; Yun Shen; S. Shi; Ke Sun; M. Pereira Vieira; Dong-Ping Wang; Fang-Zheng Wang; H. Wang; L. Wang


Archive | 2016

Three-dimensional Printing in Dentistry: An Advanced Technology for Craniofacial Regeneration

Maobin Yang; Qian Zeng; Maria Pereira Vieira; Bernardo Olsson

Collaboration


Dive into the Maobin Yang's collaboration.

Top Co-Authors

Avatar

Qian Zeng

Sun Yat-sen University

View shared research outputs
Top Co-Authors

Avatar

Junqi Ling

Sun Yat-sen University

View shared research outputs
Top Co-Authors

Avatar

Barbara E. Kream

University of Connecticut Health Center

View shared research outputs
Top Co-Authors

Avatar
Top Co-Authors

Avatar
Top Co-Authors

Avatar
Top Co-Authors

Avatar
Top Co-Authors

Avatar

Xi Wei

Sun Yat-sen University

View shared research outputs
Top Co-Authors

Avatar
Top Co-Authors

Avatar
Researchain Logo
Decentralizing Knowledge