Marcello Romeo
University of Palermo
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Publication
Featured researches published by Marcello Romeo.
Medical Microbiology and Immunology | 2013
Maurizio Bellavia; Giovanni Tomasello; Marcello Romeo; Provvidenza Damiani; Attilio Ignazio Lo Monte; Luciano Lozio; Claudia Campanella; Antonella Marino Gammazza; Francesca Rappa; Giovanni Zummo; Massimo Cocchi; Everly Conway de Macario; Alberto J.L. Macario; Francesco Cappello
In this work, we propose that for further studies of the physiopathology and treatment for inflammatory bowel diseases, an integral view of the conditions, including the triad of microbiota–heat shock proteins (HSPs)–probiotics, ought to be considered. Microbiota is the complex microbial flora that resides in the gut, affecting not only gut functions but also the health status of the whole body. Alteration in the microbiota’s composition has been implicated in a variety of pathological conditions (e.g., ulcerative colitis, UC), involving both gut and extra-intestinal tissues and organs. Some of these pathologies are also associated with an altered expression of HSPs (chaperones) and this is the reason why they may be considered chaperonopathies. Probiotics, which are live microorganisms able to restore the correct, healthy equilibrium of microbiota composition, can ameliorate symptoms in patients suffering from UC and modulate expression levels of HSPs. However, currently probiotic therapy follows ex-adiuvantibus criteria, i.e., treatments with beneficial effects but whose mechanism of action is unknown, which should be changed so the probiotics needed in each case are predetermined on the basis of the patient’s microbiota. Consequently, efforts are necessary to develop diagnostic tools for elucidating levels and distribution of HSPs and the microbiota composition (microbiota fingerprint) of each subject and, thus, guide specific probiotic therapy, tailored to meet the needs of the patient. Microbiota fingerprinting ought to include molecular biology techniques for sequencing highly conserved DNA, e.g., genes encoding 16S RNA, for species identification and, in addition, quantification of each relevant microbe.
Biomedical Papers-olomouc | 2016
Attilio Ignazio Lo Monte; Francesco Carini; Giovanni Tomasello; Marcello Romeo; Giuseppe Damiano; Antonella Marino Gammazza; Vincenzo Davide Palumbo; Salvatore Buscemi; Provvidenza Damiani; Abdo Jurjus; Alice Gerges-Geagea
AIM Intestinal dysbiosis seems to be the leading cause of inflammatory bowel diseases, and probiotics seems to represent the proper support against their occurrence. Actually, probiotic blends and anti-inflammatory drugs represent a weapon against inflammatory bowel diseases. The present study evaluates the long-term (2 years) effects of combination therapy (mesalazine plus a probiotic blend of Lactobacillus salivarius, Lactobacillus acidophilus and Bifidobacterium bifidus strain BGN4) on ulcerative colitis activity. METHOD Sixty patients with moderate-to-severe ulcerative colitis were enrolled: 30 of them were treated with a single daily oral administration of mesalazine 1200 mg; 30 patients received a single daily oral administration of mesalazine 1200 mg and a double daily administration of a probiotic blend of Lactobacillus salivarius, Lactobacillus acidophilus and Bifidobacterium bifidus strain BGN4. The treatment was carried out for two years and the clinical response evaluated according to the Modified Mayo Disease Activity Index. RESULTS All patients treated with combination therapy showed better improvement compared to the controls. In particular, the beneficial effects of probiotics were evident even after two years of treatment. CONCLUSIONS A long-term treatment modality of anti-inflammatory drugs and probiotics is viable and could be an alternative to corticosteroids in mild-to moderate ulcerative colitis.
Annali Italiani Di Chirurgia | 2007
Carmelo Sciume; Girolamo Geraci; Franco Pisello; Marcello Romeo; Geraci G; Pisello F; Sciume C; Li Volsi F; Romeo M; Giuseppe Modica
Il Giornale di chirurgia | 2008
Carmelo Sciume; Girolamo Geraci; Franco Pisello; Enrico Arnone; Marcello Romeo; Giuseppe Modica
Il Giornale di chirurgia | 2007
Girolamo Geraci; Franco Pisello; Carmelo Sciume; Annalisa Sunseri; Marcello Romeo; Francesco Li Volsi; Francesco Cupido; Giuseppe Modica
Il Giornale di chirurgia | 2008
Giuseppe Modica; Carmelo Sciume; Girolamo Geraci; Franco Pisello; Tiziana Facella; Lina Platia; Marcello Romeo; Pisello F; Geraci G; Sciume C; Li Volsi F; Platia L; Facella T; Romeo M; Modica G
Archive | 2013
Francesco Cappello; Giovanni Tomasello; Marcello Romeo; Gerardo Nardone; null Rocco; null Nardone; null Guarracino; null Compare; null Sanduzzi Zamparelli
Archive | 2013
Maurizio Bellavia; Giovanni Tomasello; M. Bellavia; Tomasello G; A. I. Lo Monte; Claudia Campanella; Antonella Marino Gammazza; F. Rappa; A.J.L. Macario; Francesco Cappello; Marcello Romeo; Giovanni Zummo; Provvidenza Damiani; L. Lozio; Massimo Cocchi; E Conway De Macario
Annali Italiani Di Chirurgia | 2007
Giuseppe Modica; Girolamo Geraci; Franco Pisello; Marcello Romeo; Geraci G; Pisello F; Carmelo Sciume; F Li Volsi; Romeo M; Modica G
Archive | 2005
Giuseppe Modica; Massimo Cajozzo; Francesco Cappello; Annalisa Sunseri; Marcello Romeo; G.I. Altieri; Luana Cassaro; Tommaso Vincenzo Bartolotta