Marco Jacono

Rhythmic oscillations of visual contrast sensitivity synchronized with action

It is well known that the motor and the sensory systems structure sensory data collection and cooperate to achieve an efficient integration and exchange of information. Increasing evidence suggests that both motor and sensory functions are regulated by rhythmic processes reflecting alternating states of neuronal excitability, and these may be involved in mediating sensory-motor interactions. Here we show an oscillatory fluctuation in early visual processing time locked with the execution of voluntary action, and, crucially, even for visual stimuli irrelevant to the motor task. Human participants were asked to perform a reaching movement toward a display and judge the orientation of a Gabor patch, near contrast threshold, briefly presented at random times before and during the reaching movement. When the data are temporally aligned to the onset of movement, visual contrast sensitivity oscillates with periodicity within the theta band. Importantly, the oscillations emerge during the motor planning stage, ∼500 ms before movement onset. We suggest that brain oscillatory dynamics may mediate an automatic coupling between early motor planning and early visual processing, possibly instrumental in linking and closing up the visual-motor control loop.

Predicting object size from hand kinematics: a temporal perspective.

Research on reach-to-grasp movements generally concentrates on kinematics values that are expression of maxima, in particular the maximum aperture of the hand and the peak of wrist velocity. These parameters provide a snapshot description of movement kinematics at a specific time point during reach, i.e., the maximum within a set of value, but do not allow to investigate how hand kinematics gradually conform to target properties. The present study was designed to extend the characterization of object size effects to the temporal domain. Thus, we computed the wrist velocity and the grip aperture throughout reach-to-grasp movements aimed at large versus small objects. To provide a deeper understanding of how joint movements varied over time, we also considered the time course of finger motion relative to hand motion. Results revealed that movement parameters evolved in parallel but at different rates in relation to object size. Furthermore, a classification analysis performed using a Support Vector Machine (SVM) approach showed that kinematic features taken as a group predicted the correct target size well before contact with the object. Interestingly, some kinematics features exhibited a higher ability to discriminate the target size than others did. These findings reinforce our knowledge about the relationship between kinematics and object properties and shed new light on the quantity and quality of information available in the kinematics of a reach-to-grasp movement over time. This might have important implications for our understanding of the action-perception coupling mechanism.

Functional effect of short-term immobilization: Kinematic changes and recovery on reaching-to-grasp

Although previous investigations agree in showing significant cortical modifications related to short-term limb immobilization, little is known about the functional changes induced by non-use. To address this issue, we studied the kinematic effect of 10h of hand immobilization. In order to prevent any movement, right handed healthy participants wore on their dominant hand a soft bandage. They were requested to perform the same reaching-to-grasping task immediately after immobilization, 1 day before (baseline 1) and in other two following days without non-use (baseline 2 and baseline 3). While no differences were found among baseline conditions, an increase of the total duration of reaching movement together with an anticipation of the time to peak velocity were observed in the first trial after immobilization. Interestingly, these initial effects decreased quickly trial-by-trial, following an exponential function till reaching values equal to those observed in the control conditions. The present findings show firstly that the transport phase of the reaching-to-grasp task was affected by a temporary reduction of sensory and motor information. Secondly, a trial-by-trial recovery of the immobilization-related changes, likely driven by the sensory inputs and motor outputs associated to the repetition of the movement has been observed. All together these results confirm a fundamental role of a continuous stream of sensorimotor signals in maintaining motor efficiency and in driving recovery process.

Representing tools as hand movements: Early and somatotopic visuomotor transformations

The term affordance defines a property of objects, which relates to the possible interactions that an agent can carry out on that object. In monkeys, canonical neurons encode both the visual and the motor properties of objects with high specificity. However, it is not clear if in humans exists a similarly fine-grained description of these visuomotor transformations. In particular, it has not yet been proven that the processing of visual features related to specific affordances induces both specific and early visuomotor transformations, given that complete specificity has been reported to emerge quite late (300-450ms). In this study, we applied an adaptation-stimulation paradigm to investigate early cortico-spinal facilitation and hand movements׳ synergies evoked by the observation of tools. We adapted, through passive observation of finger movements, neuronal populations coding either for precision or power grip actions. We then presented the picture of one tool affording one of the two grasps types and applied single-pulse Transcranial Magnetic Stimulation (TMS) to the hand primary motor cortex, 150ms after image onset. Cortico-spinal excitability of the Abductor Digiti Minimi and Abductor Pollicis Brevis showed a detailed pattern of modulations, matching tools׳ affordances. Similarly, TMS-induced hand movements showed a pattern of grip-specific whole hand synergies. These results offer a direct proof of the emergence of an early visuomotor transformation when tools are observed, that maintains the same amount of synergistic motor details as the actions we can perform on them.

Reach endpoint formation during the visuomotor planning of free arm pointing

Volitional motor control generally involves deciding ‘where to go’ and ‘how to go there’. Understanding how these two constituent pieces of motor decision coordinate is an important issue in neuroscience. Although the two processes could be intertwined, they are generally thought to occur in series, whereby visuomotor planning begins with the knowledge of a final hand position to attain. However, daily activities are often compatible with an infinity of final hand positions. The purpose of the present study was to test whether the reach endpoint (‘where’) is an input of arm motor planning (‘how’) in such ecological settings. To this end, we considered a free pointing task, namely arm pointing to a long horizontal line, and investigated the formation of the reach endpoint through eye–hand coordination. Although eye movement always preceded hand movement, our results showed that the saccade initiation was delayed by ~ 120 ms on average when the line was being pointed to as compared with a single target dot; the hand reaction time was identical in the two conditions. When the latency of saccade initiation was relatively brief, subjects often performed double, or even triple, saccades before hand movement onset. The number of saccades triggered was found to significantly increase as a function of the primary saccade latency and accuracy. These results suggest that knowledge about the reach endpoint built up gradually along with the arm motor planning process, and that the oculomotor system delayed the primary reach‐related saccade in order to gain more information about the final hand position.

Tactile perception during action observation

It has been suggested that tactile perception becomes less acute during movement to optimize motor control and to prevent an overload of afferent information generated during action. This empirical phenomenon, known as “tactile gating effect,” has been associated with mechanisms of sensory feedback prediction. However, less attention has been given to the tactile attenuation effect during the observation of an action. The aim of this study was to investigate whether and how the observation of a goal-directed action influences tactile perception as during overt action. In a first experiment, we recorded vocal reaction times (RTs) of participants to tactile stimulations during the observation of a reach-to-grasp action. The stimulations were delivered on different body parts that could be either congruent or incongruent with the observed effector (the right hand and the right leg, respectively). The tactile stimulation was contrasted with a no body-related stimulation (an auditory beep). We found increased RTs for tactile congruent stimuli compared to both tactile incongruent and auditory stimuli. This effect was reported only during the observation of the reaching phase, whereas RTs were not modulated during the grasping phase. A tactile two-alternative forced-choice (2AFC) discrimination task was then conducted in order to quantify the changes in tactile sensitivity during the observation of the same goal-directed actions. In agreement with the first experiment, the tactile perceived intensity was reduced only during the reaching phase. These results suggest that tactile processing during action observation relies on a process similar to that occurring during action execution.

Long Integration Time for Accelerating and Decelerating Visual, Tactile and Visuo-tactile Stimuli

The human visual system is good at discriminating speed but not acceleration. However, as speed is seldom constant, it is important to be able to extract speed in conditions of acceleration and deceleration. We measured visual, tactile and bimodal speed-matching over a wide range of accelerations and decelerations in a 2IFC procedure. Both visual and tactile stimuli were generated on physical wheels etched with a sinusoidal profile. During different experimental sessions the wheels could be seen, or touched, or both. Comparisons between different unimodal and bimodal matched speeds revealed similar integration times for the two modalities, in both cases around one second, suggesting that it occurs at a relatively high level of processing. Bimodal precision of speed discrimination was better than unimodal discrimination, as predicted by the maximum likelihood model of optimal integration.