Marek Napierała

Use of antiviral therapy in patients with chronic hepatitis C

Abstract Introduction: The presence of background HCV infection cannot be overestimated in view of the prevalence of chronic hepatitis C and the risk of adverse outcomes of this disease. Purpose of this study was to evaluate the effectiveness of the combined use of antiviral therapy (Roferon + Vero-Ribavirin) and resort factors in patients with chronic hepatitis C in the phase of replication. Material and methods: We observed 48 patients with chronic hepatitis C; the minimum level of activity of the process defined the phase of replication. Markers of HCV infection were determined by enzyme linked immunosorbent assay (ELISA) (a-HCV and HCV-Ig M). HCV RNA was determined twice by the polymerase chain reaction (PCR). Genotyping of hepatitis C virus was performed. Biochemical blood analysis and the study of HCV infection markers were carried out four times. Results of therapy were assessed immediately after the end of the resort (spa) treatment, then at 3, 6 and 12 months after starting treatment. At 12 months after starting treatment, all the observed patients had persistent clinical and biochemical remission. Elimination of the virus from the blood was noted in 56% of the control group and 74% of patients in the study group. Conclusions: For patients with moderately active HCV, the replication phase was characterized by asthenic-vegetative syndrome (100% of patients) with severe depression (22.92%), pain (77.08%) and dyspeptic syndrome (33.33%), moderate hypertransferaseemia (100%), slightly pronounced cholestasis (33% of patients), and signs of mesenchymal- inflammatory response.

Zdolności motoryczne i budowa somatyczna 11-letnich uczniów ze Szkoły Podstawowej nr 2 w Płońsku = Motor skills and build somatic 11-year-old students from the Primary School No. 2 in Plonsk

Bienkowska Aleksandra, Cieślicka Miroslawa, Napierala Marek, Zukow Walery, Pabianek Łukasz, Niespodzinski Bartlomiej, Sokolowska Ewa, Kuska Michalina, Pilewski Robert, Zasada Mariusz. Zdolności motoryczne i budowa somatyczna 11-letnich uczniow ze Szkoly Podstawowej nr 2 w Plonsku = Motor skills and build somatic 11-year-old students from the Primary School No. 2 in Plonsk. Journal of Education , Health and Sport . 2015;5(5): 292-299 . ISSN 2391-8306 . DOI 10.5281/zenodo.17743 http://ojs.ukw.edu.pl/index.php/johs/article/view/2015%3B5%285%29%3A292-299 https://pbn.nauka.gov.pl/works/560705 http://dx.doi.org/10.5281/zenodo.17743 Formerly Journal of Health Sciences. ISSN 1429-9623 / 2300-665X. Archives 2011 – 2014 http://journal.rsw.edu.pl/index.php/JHS/issue/archive Deklaracja. Specyfika i zawartośc merytoryczna czasopisma nie ulega zmianie. Zgodnie z informacją MNiSW z dnia 2 czerwca 2014 r., ze w roku 2014 nie bedzie przeprowadzana ocena czasopism naukowych; czasopismo o zmienionym tytule otrzymuje tyle samo punktow co na wykazie czasopism naukowych z dnia 31 grudnia 2014 r. The journal has had 5 points in Ministry of Science and Higher Education of Poland parametric evaluation. Part B item 1089. (31.12.2014).

Size of selected somatic parameters of physical education students at Kazimierz Wielki University in Bydgoszcz the years 2006-2012

The work is to determine the size of the selected somatic indicators and some morphological features of fulltime students of physical education at Kazimierz Wielki University of Bydgoszcz in the years 2006-2012. All results are presented in tables and some of them as graphics. To characterize the type of somatic structure, the following indicators were calculated for men and women: BMI, WHR, AMC and Rohrer index. Also body fat (BF) and fat-free mass (FFM) were determined. It is worth noting that the surveyed students, both men and women, in addition to physical activity resulting from their studies (physical education), in many cases practise sport at the competitive or recreational level. This implies the desired body structure characterized by low fat, large musculature and sufficient height and could make a somatic homogeneity of the studied group

Urazy i kontuzje w jeździectwie w opinii osób uprawiających sporty konne = Injuries and contusions in horse riding in the opinion of people who practice horse sports

Lisik Magdalena, Napierala Marek, Pezala Malgorzata, Zukow Walery. Urazy i kontuzje w jeździectwie w opinii osob uprawiających sporty konne = Injuries and contusions in horse riding in the opinion of people who practice Horse sports. Journal of Health Sciences. 2014;4(15):29-41. ISSN 1429-9623 / 2300-665X. http://ojs.ukw.edu.pl/index.php/johs/article/view/2014%3B4%2815%29%3A29-41 http://journal.rsw.edu.pl/index.php/JHS/article/view/2014%3B4%2815%29%3A29-41 https://pbn.nauka.gov.pl/works/513287 DOI: 10.13140/2.1.4447.6480 http://dx.doi.org/10.13140/2.1.4447.6480 The journal has had 5 points in Ministry of Science and Higher Education of Poland parametric evaluation. Part B item 1107. (17.12.2013).

Stan cech somatycznych i zdolności motorycznych 14-letnich piłkarzy z gimnazjum im. Polskich Noblistów w Więcborku = State of somatic features and motor capacity 14-year players with secondary Polish Nobel Prize winners in Więcbork

DiGeorge syndrome (DGS) which is also known as velocardiofacial syndrome is caused by a submicroscopic chromosome deletion of band 22q11. It is associated with a disturbed development of the pharyngeal arches. In this report we describe two unrelated male children with clinical features consistent with 22q11.2 microdeletion syndrome characterized by cardiac defect, recurrent respiratory infections and developmental deficiency. Definitive diagnosis is made by Fluorescence In Situ Hybridization analysis (FISH). Children underwent surgical correction of congenital heart defects. During surgery thymic aplasia was confirmed in both children, postoperative course proceeded without major complications. Our report suggests that the criteria in searching for microdeletion 22q11.2 should be expanded and applied in patients with conotruncal and non-conotruncal congenital heart defects and at least one typical feature of this syndrome.

Pathogenetic mechanisms of posttraumatic fibrosis of the uterus of white rats

AimThis study is a pathomorphological investigation the influence of factors that modulate the intensity of post-traumatic fibrosis of the rat uterus and peritoneal adhesions formation process, as well as a comparative evaluation of experimental models of formation of post-traumatic adhesions, based on the intraperitoneal injection of an aqueous suspension of barium sulfate or talc. Study subjects: female outbred albino rats weighting 200–250 g.MethodsPeritoneal adhesions were induced by a single intraperitoneal injection of an aqueous suspension of barium sulfate or talc in the pelvic area. Animals were divided into four groups: group 1 received only talc; group 2, 7-day daily administration of vitamin D; group 3 received only barium sulfate; and group 4 were administered barium sulfate contained in a hyper-sodium diet for 7 days.ResultsIntraperitoneal injection of rats with an aqueous suspension of barium sulfate, as compared with talc, resulted in a more intense manifestation of adhesions and stimulation of neoangiogenesis in the uterus. Prolonged intraperitoneal administrations of vitamin D to rats subjected to single exposure of talc, accompanied by activation of neoangiogenesis, had increased structural damage to tissues of the uterus and experienced increased intensity of the adhesion process. Prolonged exposure to salinized rats exposed to a single effect of barium sulfate, caused gross structural damage to the tissues of the uterus and induced pathological changes in the reparative processes in the background of significant amplification of post-traumatic adhesions.