Mari Sithambaram Karthikeyan

Synthesis, analgesic, anti-inflammatory and antimicrobial studies of 2,4-dichloro-5-fluorophenyl containing thiazolotriazoles

A series of 2,4-dichloro-5-fluorophenyl containing thiazolotriazoles were synthesized starting from 3-(2,4-dichloro-5-fluorophenyl)-4H-1,2,4-triazole-3-thiol. The newly synthesized compounds were characterized by IR, 1H NMR, mass and elemental analysis. Some of the synthesized compounds were tested for their anti-inflammatory, analgesic and antimicrobial activities. Compounds 8c, 8d and 8h exhibited excellent anti-inflammatory activity whereas compounds 8d, 8e and 8h showed excellent analgesic activity. Compounds 8a, 8c-e, and 8h exhibited good antibacterial activity and compounds 8c, 8e and 8h showed good antifungal activity.

Synthesis of Some Thiadiazolotriazinone Derivatives as Possible Antimicrobial Agents

A series of 7-substituted-3-t-butyl 4(H)-1,3,4-thiadiazolo(2,3-c)-1,2,4-triazine-4-one (3) have been synthesized by condensing 4-amino-6-t-butyl-3-mercapto-1,2,4-triazin-5(4H)-one (1) with substituted Arylfuroic acids (2) using POCl3 as a cyclizing agent. The newly synthesized compounds are characterized by elemental analysis, IR, 1H NMR, and mass spectral studies. The compounds were screened for their antibacterial and antifungal activities. Some of the compounds showed promising antibacterial and antifungal activity.

Synthesis and antimicrobial studies of thiazolotriazinones

A series of 6-substituted phenyl thiazolo-1,2,4-triazinones (8) were obtained by the initial reaction of 6-substituted arylmethyl-3-mercapto-1,2,4-triazin-5-ones (5) with substituted phenacyl bromides (6) and further followed by PPA cyclization. The structures of the newly synthesized compounds were confirmed by IR, (1)H NMR, Mass and analytical data. Compounds 8a, 8e, 8f and 8h exhibited good antimicrobial activity.

(E)-3-(4-Chloro­phen­yl)-1-(2,4-dichloro-5-fluoro­phen­yl)prop-2-en-1-one

In the title chalcone derivative, C15H8Cl3FO, the dihedral angle between the two benzene rings is 43.35 (8)°. Weak C—H⋯O and C—H⋯Cl intramolecular interactions involving the enone group generate S(5) and S(6) ring motifs, respectively. In the crystal structure, molecules are linked into antiparallel chains along the a axis. These chains are stacked along the b axis and short Cl⋯F contacts of 3.100 (1) Å link adjacent molecules of the antiparallel chains into dimers.

Synthesis and Antimicrobial Evaluation of Halogen-Containing Arylidene Thiazolo Triazinediones

A series of 7-substituted arylidene-1,3-thiazolo[2,3-c]-1,2,4-triazine-4,6-diones were synthesized in an one-pot multicomponent reaction of 6-arylmethyl-3-mercapto-1,2,4-triazin-5-ones with substituted benzaldehydes and monochloroacetic acid in the presence of acetic anhydride, acetic acid, and sodium acetate. The structures of the new compounds were supported by IR, 1H NMR, MS, and analytical data. All the new compounds were tested for their antibacterial and antifungal activity. Arylidene thiazolo triazinediones with 1,3-benzodioxolo substituent at seventh and p-chlorophenyl or 2,4-dichlorophenyl substituents at third displayed good antibacterial and antifungal activity. And also compound bearing 2,3,5-trimethoxyphenyl substituent at seventh and 2,4-dichlorophenyl substituent at third displayed good activity.

2,3-Dibromo-1-(2,4-dichloro-5-fluoro-phen-yl)-3-phenyl-propan-1-one.

In the title compound, C15H9Br2Cl2FO, the dihedral angle between the two aromatic rings is 6.0 (1)°. The dibromoethane fragment of the propan-1-one unit is disordered over two positions, with occupancies of ca 0.83 and 0.17. The crystal structure is stabilized by intermolecular C—H⋯O hydrogen bonds, C—H⋯π interactions, and Br⋯Cl [3.505 (2) and 3.576 (6) Å] and Cl⋯F [3.176 (2) Å] short contacts.

N-(2-Methoxy­phen­yl)thio­urea

Phenylthiourea (PTU) has been used as a pesticide and exhibits both herbicidal and rodenticidal activity. The toxic effects of thiourea derivatives seem to arise from disturbing the carbohydrate metabolism and it has been shown that PTU causes chronic goitrogenic and other glandular problems in humans. Thiourea derivatives have also been screened as allergenic factors. Thiourea and its derivatives (including PTU) are used as corrosion inhibitors and as accelerators in the rubber industry. We present here the synthesis and crystal structure of the title thiourea compound, (I).

2-Bromo-1-(4-methyl-phen-yl)-3-phenyl-prop-2-en-1-one.

In the crystal structure of the title compound, C16H13BrO, the two benzene rings are twisted from each other with a dihedral angle of 52.55 (9)°. Both an intramolecular C—H⋯Br hydrogen bond, which generates an S(6) ring motif, and a short Br⋯O contact [2.9907 (19) Å] may influence the conformation of the molecule. The crystal packing is stabilized by weak intermolecular C—H⋯O interactions.

Erratum: 2-Bromo-1-(4-methyl-phen-yl)-3-phenyl-prop-2-en-1-one. Corrigendum.

Corrigendum to Acta Cryst. (2008), E64, o1559.