Maria Chomyszyn-Gajewska
Jagiellonian University
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Featured researches published by Maria Chomyszyn-Gajewska.
Biomaterials | 2002
Maria Chomyszyn-Gajewska; Barbara Czajkowska; M. Błażewicz; Elżbieta Pamuła; Maria Ptak
The purpose of the study was to examine the response of macrophages and the concentration of selected released cytokines following contact with a new carbon-polylactide composite. The macrophages were grown on samples of the materials and on each of its components separately. Viability of the cells as well as concentrations of interleukins IL-6, IL-10, IL-12 and TNF-alpha were then determined. Some differences in the viability of the cells were demonstrated. They varied according to the kind of material used. After incubation with the serum, the composite and its components induced the release of IL-6, IL-12 and TNF-alpha which did not differ significantly from one another.
Journal of Clinical Periodontology | 2016
Phoebus N. Madianos; William Papaioannou; David Herrera; Mariano Sanz; Amelie Baeumer; Anna Bogren; Philippe Bouchard; Maria Chomyszyn-Gajewska; Korkud Demirel; Rok Gašperšič; Marina Giurgiu; Filippo Graziani; Karin Jepsen; Søren Jepsen; Tiernan O′Brien; Ioannis Polyzois; Philip M. Preshaw; Mia Rakic; Michele Reners; Nives Rincic; Andreas Stavropoulos; Serdar Sütcü; Christian Verner; Juan Carlos Llodra
AIM The aim was to assess the potential trends in Periodontology and Periodontics in Europe that might be anticipated by the year 2025, using the Delphi method. MATERIAL AND METHODS The expert opinion of 120 experts was sought through the use of an open-ended questionnaire, developed by an advisory group, containing 40 questions concerning the various trends in periodontology. RESULTS The experts (113 responders) expect a stabilization of the prevalence of periodontitis, both for the chronic as well as the aggressive cases, but an increase in implant-related diseases up to the year 2025. Concurrently, the importance of implants is seen to be increasing. They foresee an increased demand for postgraduate periodontology and implantology training. This is mirrored in an increase in publications for implant dentistry and increase in demand and need for training. Concerning the patients, better-informed individuals seeking more routine check-ups are expected. CONCLUSION A continued need for specialized periodontists, but also well trained dental practitioners is foreseen for next decade in Europe. Apart from periodontology they will be increasingly exposed to and trained in implant dentistry.
Oral Diseases | 2017
Katarzyna Gawron; Grzegorz Bereta; Zuzanna Nowakowska; Katarzyna Łazarz-Bartyzel; Jan Potempa; Maria Chomyszyn-Gajewska; Renata Górska; Paweł Plakwicz
OBJECTIVES To establish whether two families from Malopolska and Mazovia provinces in Poland are affected by hereditary gingival fibromatosis type 1, caused by a single-cytosine insertion in exon 21 of the Son-of-Sevenless-1 gene. MATERIAL AND METHODS Six subjects with hereditary gingival fibromatosis and five healthy subjects were enrolled in the study. Gingival biopsies were collected during gingivectomy or tooth extraction and used for histopathological evaluation. Total RNA and genomic DNA were purified from cultured gingival fibroblasts followed by cDNA and genomic DNA sequencing and analysis. RESULTS Hereditary gingival fibromatosis was confirmed by periodontal examination, X-ray, and laboratory tests. Histopathological evaluation showed hyperplastic epithelium, numerous collagen bundles, and abundant-to-moderate fibroblasts in subepithelial and connective tissue. Sequencing of exons 19-22 of the Son-of-Sevenless-1 gene did not reveal a single-cytosine insertion nor other mutations. CONCLUSIONS Patients from two Polish families under study had not been affected by hereditary gingival fibromatosis type 1, caused by a single-cytosine insertion in exon 21 of the Son-of-Sevenless-1 gene. Further studies of the remaining regions of this gene as well as of other genes are needed to identify disease-related mutations in these patients. This will help to unravel the pathogenic mechanism of gingival overgrowth.
Pomeranian journal of life sciences | 2018
Joanna Słowik; Tomasz Kaczmarczyk; Jadwiga Stypułkowska; Maria Chomyszyn-Gajewska; Małgorzata Zaleska; Anna Bednarczyk; Marcin Wnuk
Introduction: Standard local anaesthetics do not guarantee complete absence of pain during endodontic debridement of the in lamed pulp. We investigated whether the addition of mg of morphine to local articaine anaesthesia as compared to articaine alone could reduce pain sensations during endodontic debridement and within h after the procedure. Materials and methods: Thirty-two patients with pain attributed to irreversible pulpitis of the irst upper molar participated in this randomized, double-blind trial. Patients were randomly assigned either to the study group (patients receiving periapical injection of modi ied local anaesthetic solution with morphine, n = ) or to the control group (patients receiving standard anaesthetic solution without morphine, n = ). The pain intensity was assessed using the visual analogue scale and verbal score before and directly after endodontic debridement, as well as at , , , , and h after the procedure. Results: Neither the visual analogue scale nor verbal score differed between both groups before or during the endodontic debridement, as well as during -hour follow-up. However, there was an insigni icant tendency for greater pain relief in patients treated with articaine and morphine at h after endodontic debridement (p = . ). The study was funded by a Jagiellonian University in Poland (JU) grant, and was registered with the JU Ethical Committee No. /K/ZDS/ . Conclusions: The addition of morphine to local articaine anaesthesia does not in luence pain intensity in patients undergoing endodontic debridement in contrast to the previously described pain-relief effect in patients after oral surgery. However, future studies are needed to evaluate the role of opioids in local anaesthesia in endodontic procedures.
Connective Tissue Research | 2018
Katarzyna Gawron; Katarzyna Łazarz-Bartyzel; Anna Kowalska; Grzegorz Bereta; Zuzanna Nowakowska; Paweł Plakwicz; Jan Potempa; Andrzej Fertala; Maria Chomyszyn-Gajewska
ABSTRACT Purpose: Investigate the content of fibrotic fibrils in gingival tissue and the proliferation of fibroblasts collected from recurrent and non-recurrent hereditary gingival fibromatosis (HGF) and idiopathic gingival fibromatosis (IGF). Methods: Gingival biopsies were collected from HGF (n = 3) and IGF (n = 3) donors with recurrent and non-recurrent gingival overgrowths and from a control group (Ctrl, n = 3). Hematoxylin staining was performed to evaluate the histomorphology of gingival tissue. Heidenhain’s AZAN trichrome staining served for visualization of fibrotic fibrils in gingiva. Quantitative analysis of the content of fibrotic fibrils in gingival tissue was performed using a polarized light microscope. Proliferation was evaluated at 24 h, 48 h, and 72 h in fibroblast cultures using a cell proliferation ELISA assay based on 5-bromo-2ʹ-deoxyuridine (BrdU). Results: Numerous blood vessels and fibroblasts were observed in recurrent overgrowths, whereas moderate blood vessels and moderate to scanty fibroblasts were detected in non-recurrent overgrowths. Heidenhain’s staining revealed numerous collagen fibers in both recurrent and non-recurrent overgrowths. Quantitative analysis in a polarizing microscope showed significant accumulation of fibrotic fibrils exclusively in the overgrowths with the recurrence. In all time-points, increased proliferation of cells from all recurrent overgrowths was observed, but not from overgrowths which do not reoccur. Conclusions: The study revealed that recurrent gingival overgrowths consist of highly fibrotic and dense connective tissue with numerous blood vessels and abundant fibroblasts. We also demonstrated that unlike fibroblasts derived from overgrowths, which did not present recurrence, fibroblasts derived from highly fibrotic and recurrent overgrowths maintain high rate of proliferation in vitro.
Arthritis & Rheumatism | 2017
Anja Schwenzer; Anne Marie Quirke; Anna M. Marzeda; Alicia Wong; Anna B Montgomery; Harlan Sayles; Sigrun Eick; Katarzyna Gawron; Maria Chomyszyn-Gajewska; Katarzyna Łazarz-Bartyzel; Simon J. Davis; Jan Potempa; Benedikt M. Kessler; R. Fischer; P J Venables; Jeffrey B. Payne; Ted R. Mikuls; Kim S. Midwood
In addition to the long‐established link with smoking, periodontitis (PD) is a risk factor for rheumatoid arthritis (RA). This study was undertaken to elucidate the mechanism by which PD could induce antibodies to citrullinated peptides (ACPAs), by examining the antibody response to a novel citrullinated peptide of cytokeratin 13 (CK‐13) identified in gingival crevicular fluid (GCF), and comparing the response to 4 other citrullinated peptides in patients with RA who were well‐characterized for PD and smoking.
European Journal of Dental Education | 2008
Ross S. Hobson; Sarah L. Rolland; Jerome Rotgans; Meta Schoonheim-Klein; Helen Best; Maria Chomyszyn-Gajewska; David Dymock; Rashid M. Essop; Jim Hupp; Rita Kundzina; Robert M. Love; Rafique A. Memon; Mohammed Moola; Laura M. Neumann; Nehir Ozden; Kathleen Roth; Paulette Samwel; Juan Villavicencio; Paul Wright; Winfried Harzer
Journal of Oral Pathology & Medicine | 2014
Ayman Abdel-Haq; Kusnierz-Cabala B; Dagmara Darczuk; Eliza Sobuta; Paulina Dumnicka; Anna Wojas-Pelc; Maria Chomyszyn-Gajewska
Journal of international oral health : JIOH | 2015
Agata Dudzik; Maria Chomyszyn-Gajewska; Katarzyna Łazarz-Bartyzel
Polish Journal of Pathology | 2018
Zuzanna Oruba; Tomasz Kaczmarzyk; Katarzyna Urbańczyk; Artur Jurczyszyn; Szymon Fornagiel; Krystyna Gałązka; Anna Bednarczyk; Maria Chomyszyn-Gajewska