Maria Iglesias
University of Buenos Aires
Network
Latest external collaboration on country level. Dive into details by clicking on the dots.
Publication
Featured researches published by Maria Iglesias.
Journal of Histochemistry and Cytochemistry | 2010
Marcelo Hill; Daniel Mazal; Verónica A. Biron; Laura Pereira; Luis Ubillos; Edgardo Berriel; Hafiz Ahmed; Teresa Freire; Mariella Rondán; Gerardo R. Vasta; Fu Tong Liu; Maria Iglesias; Eduardo Osinaga
Galectin-3 (Gal-3) is a multifunctional protein that plays different roles in cancer biology. To better understand the role of Gal-3 and its ligands during colon carcino-genesis, we studied its expression in tumors induced in rats treated with 1,2-dimethylhydrazine (DMH) and in human tissues. Normal colon from untreated rats showed no staining using two specific monoclonal antibodies. In contrast, morphologically normal colon from DMH-treated rats and dysplastic aberrant crypt foci were strongly stained, indicating that increased Gal-3 expression is an early event during the neoplastic transformation in colon cells. Gal-3 was weakly expressed in adenocarcinomas. Overall, the Gal-3 expression pattern observed in the DMH rat model closely resembles that displayed by human colon stained with the same antibodies. We also found that Gal-3 phosphorylation diminishes in serines while increasing in tyrosines during rat colon carcinogenesis. Finally, we showed that Gal-3–ligands expression is strikingly similar in rat and human malignant colon and in non-malignant tissues. In conclusion, the DMH-induced rat colon cancer model displays expression patterns of Gal-3 and its ligands very similar to those observed in human samples. This animal model should contribute to clarifying the role of Gal-3 in colon carcinogenesis and also to finding effective preventive cancer agents based on Gal-3 targeting.
Biochimica et Biophysica Acta | 2003
Maria Iglesias; María T Elola; Vanesa Martinez; Nilda E. Fink; Carlota Wolfenstein-Todel
The unfolding process of galectin-1 (Gal-1) in the presence of a denaturing agent was examined using fluorescence and far-UV circular dichroism (CD) spectroscopy determinations, and was found to be completely reversible. The data showed that the transitions of guanidine hydrochloride (GdnHCl)-induced lectin unfolding, in the absence of ligand, were biphasic in nature, clearly showing the existence of at least one stable intermediate. On the other hand, the unfolding in the presence of disaccharide yielded data that could fit very well to a two-state model, indicating a stabilizing effect of the ligand. The folding intermediate was further characterized by size exclusion chromatography, near-UV CD and anilinonaphtalene sulfonate binding, and shown to belong to the molten globule type. Strikingly, this intermediate retained its carbohydrate-binding specificity, as evidenced by the tryptophan fluorescence changes detected upon its interaction with lactose.
Ciência & Educação | 2008
Elsa Meinardi; Andrea Revel Chion; Elina Godoy; Maria Iglesias; Inés Rodríguez Vida; María Victoria Plaza; Leonor Bonan
In this work, we made assessments about the status of teacher training in sex education in Argentina and we propose some research problems. At the same time, we present some preliminary data from high school students in two distinct age groups: teenagers 14 to 16 years of age and adults who resumed their studies after several years out of formal education. Our objective was to explore some conceptions of students, so they could serve to guide for the planning classes on Sexual Health.
arXiv: Physics Education | 2009
Alejandro Gangui; Maria Iglesias; Cynthia Quinteros
Recent studies have shown that not only primary school students but also their future teachers reach science courses with pre-constructed and consistent models of the world surrounding them. These ideas include many misconceptions which turn out to be robust and hence make difficult an appropriate teaching-learning process. We have designed some tools (and show here results with a questionnaire) that proved helpful in putting in evidence some of the most frequently used alternative models on a few basic astronomical notions. We have tested this questionnaire with preservice elementary teachers from various normal schools in Buenos Aires and made a first analysis of the results. The collection of data recovered so far shows that some non-scientific conceptions are indeed part of the prospective teachers’ (scientific) background and, therefore, that the issue deserves special attention during their formal training.
Journal of Immunology | 1998
Gabriel A. Rabinovich; Maria Iglesias; Nidia M. Modesti; Leonardo F. Castagna; Carlota Wolfenstein-Todel; Clelia M. Riera; Claudia E. Sotomayor
arXiv: Physics Education | 2008
Alejandro Gangui; Maria Iglesias; Cynthia Quinteros
arXiv: Physics Education | 2008
Maria Iglesias; Cynthia Quinteros; Alejandro Gangui
arXiv: Physics Education | 2015
Alejandro Gangui; Esteban Dicovskiy; Maria Iglesias
The FASEB Journal | 2015
Patricia Rodriguez; María Teresa Mateo; Maria Iglesias; Josefina Martínez Reinoso; Fima Lifshitz; Susana Molgatini; Angela Beatriz Argentieri
Archive | 2013
Claudia E. Sotomayor; Leonardo F. Castagna; Carlota Wolfenstein-Todel; A. Rabinovich; Maria Iglesias; Nidia M. Modesti