Maria Luisa Marino

Addition reactions of heterocycles—IV : Indoles and nitrilimines

Abstract The reactivity of indole derivatives towards nitrilimines has been studied. Substituents at positions 1, 2 and 3 of the indole ring greatly affect the course of the reaction. 1,3-Dipolar cycloaddition products (3a,8a,dihydropyrazole-[3,4-b]-indole derivatives) and non-cyclic addition products (3-indolyl derivatives) were obtained depending on these substituents. The structures reported were assigned on the basis of satisfactory analytical, spectroscopic and chemical data.

New diterpenes from Sideritis sicula

Abstract Two new diterpenes have been isolated from Sideritis sicula : sideripol, ent -18-acetoxy-7α-hydroxykaur-15-ene and epoxysideritriol, ent -15β,16β-epoxykauran-7α,17,18-triol. The previously known diterpene eubol, ent -7α-acetoxykaur-16-en-15β,18 diol has also been obtained from the same source.

Hypercalciuria and kidney calcifications in terminal 4q deletion syndrome: Further evidence for a putative gene on 4q

We report a newborn girl with a de novo terminal 4q deletion (q31.3 → qter) and a characteristic phenotype of minor facial anomalies, cleft palate, congenital heart defect, abnormalities of hands and feet, and postnatal onset of growth deficiency. Laboratory studies showed excessive urinary calcium excretion on standard milk formula and on oral calcium load. Blood measurements of parathyroid hormone, calcitonin, bicarbonate, calcium, phosphorus, magnesium, sodium, chlorine, potassium, and urinary measurements of phosphorus, magnesium, sodium, chlorine, potassium were normal for age. At 2 months of life, ultrasonography showed kidney calcifications. Clinical and laboratory data support the diagnosis of absorptive hypercalciuria or abnormal regulation of calcium‐sensing receptors in the renal tubules. The evidence of hypercalciuria and kidney calcifications associated with 4q terminal deletion strengthens the hypothesis that a putative gene for hypercalciuria is located on the terminal segment of chromosome 4q.

Coumarins from Seseli bocconi

Abstract A new khellactone, bocconin, in addition to known compounds, have been isolated from Seseli bocconi subsp. bocconi and subsp. praecox Gamisans . Their structures were elucidated on the basis of spectral analyses and hydrolytic studies.

Siderone, a diterpene from Sideritis syriaca

Abstract Siderone, a new keto-diterpene, has been isolated from the petrol extract of the inflorescence of Sideritis syriaca . Its structure and stereochemis

Ucriol, an epoxy-diterpene from Sideritis syriaca

Abstract The isolation of a new epoxy-diterpene from the inflorescence of Sideritis syriaca (S. sicula Ucria) is described. Its structure and stereochemistry were established by spectroscopy and partial synthesis.

Phytochemical Investigation of the Labiate Dorystoechas hastata

Abstract Carnosol (11,12-dihydroxyabieta-8,11,13-trien-20-oic acid 20,7-lactone), and rosmanol (7α, 11, 12-trihydroxy-abieta-8, 11, 13-trien-20 oic acid-20, 6-lactone), two abietane diterpenes previously isolated from Rosmarinus officinalis, have been isolated from leaves of Dorystoechas hastata. Luteolin, luteolin-7-glucoside, 6-methoxyluteolin-7-glucoside, caffeic acid and chlorogenic acid have also obtained from the same source. The co-occurrence of carnosol, rosmanol and 6-methoxyluteolin-7-glucoside support the close relationship of these two genera.

Carbon-13 Nuclear Magnetic Resonance Spectra of 2-Arylidene-3(2H)-benzofuranones

Etude de la structure des arylidene-2(2H) benzofuranones-3 substitues a partir des spectres RMN de 13 C, et discussion sur les effets substituants

Partial synthesis of ent-kaur-16-ene-15β,18-diol and ent-kaur-16-ene-7α,15β,18-triol

Treatment of ent-15β,16β-epoxykauran-18-ol (V) with boron trifluoride–ether complex in dimethyl sulphoxide or direct photo-oxygenation of ent-kaur-15-en-18-ol (IV) gave the expected ent-kaur-16-ene-15β,18-diol (I). This product is suggested to be identical with natural candidiol. Treatment of ent-15β,16β-epoxykaurane-7α,18-diol (VIII)(natural sideroxol) with boron trifluoride–ether complex in dimethyl sulphoxide or photo-oxygenation of ent-kaur-15-ene-7α,18-diol (II)(natural sideridiol) gave ent-kaur-16-ene-7α,15β,18-triol (VII).

Synthesis, molecular, and crystal structure of a new, unexpected polycyclic system: 5,12:10,12-dimethano-12H-pyrazolo[3,4-b]pyrazolo[4′,3′:6,7]azapino[2,3-f]azocine

By reacting 1-phenyl-3-R-5-methylaminopyrazoles (1a, b) and hexane-2,5-dione (2) in acetic acid compounds (4a, b), containing the title system, were obtained. They were characterized by elemental analysis, n.m.r. spectroscopy and, for (4a), X-ray crystallography of a single crystal. The structure is characterized by a fused hexacyclic system which includes two N-phenyl-substituted pyrazole rings adjacent to two azepine ones in the half-chair conformation and, finally, two five-membered fused rings.