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Dive into the research topics where Marianne Regard is active.

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Featured researches published by Marianne Regard.


Perceptual and Motor Skills | 1982

Children's Production on Verbal and Non-Verbal Fluency Tasks.

Marianne Regard; Esther Strauss; Paul Knapp

Children aged 6 to 13 yr. were given verbal and non-verbal fluency tasks as well as the Vocabulary and Block Design subtests of the WISC-R. The results, providing normative data, showed that the fluency tasks are age-, but not sex-dependent, and are only modestly correlated to one another and to standard measures of intelligence.


The Journal of Neuroscience | 2006

Disruption of Right Prefrontal Cortex by Low-Frequency Repetitive Transcranial Magnetic Stimulation Induces Risk-Taking Behavior

Daria Knoch; Lorena R. R. Gianotti; Alvaro Pascual-Leone; Valerie Treyer; Marianne Regard; Martin Hohmann; Peter Brugger

Decisions require careful weighing of the risks and benefits associated with a choice. Some people need to be offered large rewards to balance even minimal risks, whereas others take great risks in the hope for an only minimal benefit. We show here that risk-taking is a modifiable behavior that depends on right hemisphere prefrontal activity. We used low-frequency, repetitive transcranial magnetic stimulation to transiently disrupt left or right dorsolateral prefrontal cortex (DLPFC) function before applying a well known gambling paradigm that provides a measure of decision-making under risk. Individuals displayed significantly riskier decision-making after disruption of the right, but not the left, DLPFC. Our findings suggest that the right DLPFC plays a crucial role in the suppression of superficially seductive options. This confirms the asymmetric role of the prefrontal cortex in decision-making and reveals that this fundamental human capacity can be manipulated in normal subjects through cortical stimulation. The ability to modify risk-taking behavior may be translated into therapeutic interventions for disorders such as drug abuse or pathological gambling.


NeuroImage | 2002

Affective Judgments of Faces Modulate Early Activity (160 ms) within the Fusiform Gyri

Diego A. Pizzagalli; Dietrich Lehmann; Andrew M. Hendrick; Marianne Regard; Roberto D. Pascual-Marqui; Richard J. Davidson

Functional neuroimaging studies have implicated the fusiform gyri (FG) in structural encoding of faces, while event-related potential (ERP) and magnetoen- cephalography studies have shown that such encoding occurs approximately 170 ms poststimulus. Behavioral and functional neuroimaging studies suggest that pro- cesses involved in face recognition may be strongly modulated by socially relevant information conveyed by faces. To test the hypothesis that affective informa- tion indeed modulates early stages of face processing, ERPs were recorded to individually assessed liked, neutral, and disliked faces and checkerboard-reversal stimuli. At the N170 latency, the cortical three-dimen- sional distribution of current density was computed in stereotactic space using a tomographic source local- ization technique. Mean activity was extracted from the FG, defined by structure-probability maps, and a meta-cluster delineated by the coordinates of the voxel with the strongest face-sensitive response from five published functional magnetic resonance imaging studies. In the FG, 160 ms poststimulus, liked faces elicited stronger activation than disliked and neutral faces and checkerboard-reversal stimuli. Further, confirming recent results, affect-modulated brain elec- trical activity started very early in the human brain (112 ms). These findings suggest that affective fea- tures conveyed by faces modulate structural face en- coding. Behavioral results from an independent study revealed that the stimuli were not biased toward par- ticular facial expressions and confirmed that liked faces were rated as more attractive. Increased FG ac- tivation for liked faces may thus be interpreted as reflecting enhanced attention due to their saliency.


Neuroreport | 1999

Rapid emotional face processing in the human right and left brain hemispheres : an ERP study

Diego A. Pizzagalli; Marianne Regard; Dietrich Lehmann

Imaging work has begun to elucidate the spatial organization of emotions; the temporal organization, however, remains unclear. Adaptive behavior relies on rapid monitoring of potentially salient cues (typically with high emotional value) in the environment. To clarify the timing and speed of emotional processing in the two human brain hemispheres, event-related potentials (ERPs) were recorded during hemifield presentation of face images. ERPs were separately computed for disliked and liked faces, as individually assessed by postrecording affective ratings. After stimulation of either hemisphere, personal affective judgements of face images significantly modulated ERP responses at early stages, 80-116 ms after right hemisphere and 104-160 ms after left hemisphere stimulation. This is the first electrophysiological evidence for valence-dependent, automatic, i.e. pre-attentive emotional processing in humans.


Cognitive Neuropsychiatry | 1997

Illusory Reduplication of One's Own Body: Phenomenology and Classification of Autoscopic Phenomena

Peter Brugger; Marianne Regard; Theodor Landis

Autoscopic phenomena involve the illusory reduplication of ones own body. The literature on the topic is widely scattered and suffers from considerable terminological and conceptual inconsistencies. This article proposes a classification scheme based on phenomenological criteria. Along with examples of illustrative cases, we outline the main features of autoscopic hallucinations, heautoscopy proper, the feeling of a presence, the out-of-body experience, and negative and inner forms of autoscopic phenomena. We also discuss the need for a differentiation of autoscopic phenomena from reduplicative paramnesias and the misidentification syndromes. Finally, the concept of a neuromatrix (Melzack, 1990) is proposed as a starting point for the understanding of the neuronal mechanisms underlying autoscopic phenomena.


Experimental Brain Research | 1996

Intermanual transfer of proximal and distal motor engrams in humans

Gregor Thut; Norman D. Cook; Marianne Regard; K. L. Leenders; Ulrike Halsband; Theodor Landis

We studied intermanual motor transfer for right-to-left or left-to-right direction of transfer between either proximal or distal upper extremity muscle groups. The influence of previously acquired motor engrams (original learning, OL) on learning efficiency of the contralateral side (transfer learning, TL) was examined in 26 right-handed healthy subjects. The task consisted of the drawing of meaningless figures. During TL, OL figures had to be reproduced as vertical mirror reversals. Data revealed a benefit for right-to-left but not left-to-right direction of transfer for time to complete a figure as well as a left-to-right transfer benefit for spatial motor precision. Furthermore, a benefit for intermanual transfer of training between proximal but not distal muscle groups was found when movement time to complete a figure was evaluated. Of special interest was the observation of a disadvantage due to prior contralateral learning for performance at right distal effectors. The asymmetrical transfer benefits with respect to side are in line with previous findings and support the proficiency model and the cross-actiation model. Results further showed that intermanual transfer of training might differ with respect to muscle group involvement and suggest that, although primarily facilitating, previous opposite hand training may lead to inhibitory influences on subsequent contralateral reproduction.


Neuropsychologia | 1989

Shift of functional cerebral asymmetry during the menstrual cycle.

Gabriele Heister; Theodor Landis; Marianne Regard; Peter Schroeder-Heister

This study investigated whether for females, who are said to be less strongly lateralized for cognitive functions than men, hemispheric superiority might depend on the phase of the menstrual cycle. The results show that while asymmetry in lexical decisions did not change throughout the menstrual cycle, asymmetry in face perception decreased linearly from a large right hemisphere superiority during menstruation to a small left hemisphere superiority during the premenstrual phase. This is seen as being relevant not only for the discussion of sex differences in cerebral asymmetry but also for the concept of cerebral organization in general.


Brain and Language | 1980

Iconic reading in a case of alexia without agraphia caused by a brain tumor: A tachistoscopic study

Theodor Landis; Marianne Regard; Andreu Serrat

Abstract The lack of nonverbal reading comprehension in the clinical disconnection syndrome, alexia without agraphia, has been contradictory to the relative reading comprehension of the right hemisphere in split brains. We report a 39-year-old patient with verbal alexia without agraphia caused by brain tumor. On rapid tachistoscopic presentation of object names, he denied seeing anything but showed nonverbal reading comprehension by pointing to the corresponding objects. He lost this ability when he recovered ability to name individual letters of the object names. Our results suggest that even partial verbal reading such as the naming of single letters makes demonstration of iconic reading impossible and that total functional disconnection from verbalization, as initially noted in this case or in split brain studies, is necessary to show nonverbal reading comprehension.


Neurology | 1989

Persistent cognitive impairment in climbers after repeated exposure to extreme altitude

Marianne Regard; O. Oelz; Peter Brugger; Theodor Landis

We performed neuropsychological testing in eight world class climbers who had reached summits higher than 8,500 meters without supplementary oxygen. Five had mildly impaired concentration, short-term memory, and ability to shift concepts and control errors. There were no defects in perception or other cognitive activities. The pattern of impairment suggests malfunctioning of bifronto-temporo-limbic structures. Repeated extreme-altitude exposure can cause mild but persistent cognitive impairment.


Epilepsia | 1985

Unilateral Limbic Epileptic Status Activity: Stereo EEG, Behavioral, and Cognitive Data

Heinz Gregor Wieser; S. Hailemariam; Marianne Regard; Theodor Landis

Summary: We report data from four patients with unilateral epileptiform status activity within different structures of the temporal lobe, recorded during stereoelectroencephalographic presurgical evaluation. The ictal clinical symptoms accompanying neocortical and mesiobasal limbic discharges (two patients with complex partial status epilepticus) consisted of various psychosensory and vegetative signs, which can be understood on the basis of the spatiotemporal analysis of the discharges. The other two patients with circumscribed long‐lasting mesiobasal limbic epileptiform activity represent unilateral pure limbic status epilepticus and were characterized by a marked behavioral syndrome (with stickiness, aggressivity, etc.) and a monomorphic gustatory aura continua, respectively. The latter patient, with left hippocampal discharges of nearly continuous epileptiform character, was also assessed with tachistoscopic tasks. Performance revealed cognitive impairment only in the epileptically discharging hemisphere and in dependence on the quality of the EEG pattern. After unilateral selective amygdalohippocampectomy, the two patients with limbic status epilepticus were seizure free and had markedly improved behavior and cognitive functions. Thus, patients with nonconvulsive status epilepticus represent an ideal model, although rare, to correlate behavior alterations and brain dysfunction.

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Djana Albert

Boston Children's Hospital

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Ruth Campbell

University College London

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