Marie-Anne Gougerot-Pocidalo

Priming of the neutrophil NADPH oxidase activation: role of p47phox phosphorylation and NOX2 mobilization to the plasma membrane

Neutrophils play an essential role in host defense against microbial pathogens and in the inflammatory reaction. Upon activation, neutrophils produce superoxide anion (

ASK1-p38 MAPK-p47phox activation is essential for inflammatory responses during tuberculosis via TLR2-ROS signalling

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TLR9 Activation Induces Normal Neutrophil Responses in a Child with IRAK-4 Deficiency: Involvement of the Direct PI3K Pathway

), which generates other reactive oxygen species (ROS) such as hydrogen peroxide (H2O2), hydroxyl radical (

Zymosan induces NADPH oxidase activation in human neutrophils by inducing the phosphorylation of p47phox and the activation of Rac2: involvement of protein tyrosine kinases, PI3Kinase, PKC, ERK1/2 and p38MAPkinase.

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NOXO1 phosphorylation on serine 154 is critical for optimal NADPH oxidase 1 assembly and activation

) and hypochlorous acid (HOCl), together with microbicidal peptides and proteases. The enzyme responsible for