Pham My-Chan Dang

Priming of the neutrophil NADPH oxidase activation: role of p47phox phosphorylation and NOX2 mobilization to the plasma membrane

Neutrophils play an essential role in host defense against microbial pathogens and in the inflammatory reaction. Upon activation, neutrophils produce superoxide anion (

Francisella Acid Phosphatases Inactivate the NADPH Oxidase in Human Phagocytes

{\text{O}}_2 ^{ - .}

The prolyl isomerase Pin1 acts as a novel molecular switch for TNF-α–induced priming of the NADPH oxidase in human neutrophils

), which generates other reactive oxygen species (ROS) such as hydrogen peroxide (H2O2), hydroxyl radical (

Zymosan induces NADPH oxidase activation in human neutrophils by inducing the phosphorylation of p47phox and the activation of Rac2: involvement of protein tyrosine kinases, PI3Kinase, PKC, ERK1/2 and p38MAPkinase.

{\text{OH}}^{ \bullet }

Increased reactive oxygen species production and p47phox phosphorylation in neutrophils from myeloproliferative disorders patients with JAK2 (V617F) mutation.

) and hypochlorous acid (HOCl), together with microbicidal peptides and proteases. The enzyme responsible for