Mário Jorge Melhor Heine D'Assis

Caracterização clínica, diagnóstico histopatológico e distribuição geográfica das neoplasias mamárias em cadelas de Salvador, Bahia

Os tumores espontâneos da glândula mamaria representam, nas cadelas, a neoplasia mais observada na clinica de pequenos animais, justificando o grande interesse dos pesquisadores no estudo dessa lesao. Este trabalho teve por objetivo determinar a frequencia dos tumores mamarios em cadelas atendidas no HOSPMEV/UFBA, no municipio de Salvador, no periodo de janeiro de 2006 a abril de 2008, bem como realizar a caracterizacao clinica, a classificacao histopatologica e o georreferenciamento dessa patologia. Os resultados revelaram alta prevalencia de neoplasias mamarias em cadelas, em sua maioria tumores, em estadios mais avancados, sendo os carcinomas em tumores mistos o tipo histologico predominante. Observou-se ainda a correlacao das caracteristicas socioeconomicas da populacao estudada com fatores sabidamente prognosticos para neoplasias mamarias em cadelas. Esses resultados refletem a procura tardia da assistencia Medica Veterinaria. Por isso, e ur gente educar a populacao quanto a prevencao e deteccao da neoplasia mamaria nas cadelas, buscando o diagnostico precoce e a terapeutica adequada. Palavras-chave: tumor de mama, estadiamento clinico, fatores socioeconomicos.

Colopexia e deferentopexia associadas à omentopexia no tratamento da hérnia perineal em cães: um estudo de trinta casos

Several surgical techniques have been proposed for perineal hernia correction in dogs and regardless of the used method the surgical risk related to clinical status and animal age should always be considered, since the involvement of the urinary tract and/or digestive tract is frequent and the geriatric patient can present multiple problems that significantly affect their tolerance to anesthesia, surgery and infections. In this context, this study aimed to evaluate the use of colopexy and deferentopexy associated with omentopexy as surgical alternative in 30 elderly dogs, systemically compromised, which had perineal hernia and concomitant rectal anomaly. The cases analysis showed that the proposed surgical technique allowed the inspection and evaluation of abdominal organs, particularly those with hernial content involved; the distal colon linear format restoration, reducing its diameter and encouraging a normal function return, effective setting and secure cranial prostate and urinary bladder repositioning, avoiding further caudal displacement; satisfactory tissue repair and defect occlusion of the pelvic diaphragm. Thus, it was concluded that the proposed procedure has therapeutic value for dogs with perineal hernia and concomitant rectal sacculation.

The effect of naltrexone as a carboplatin chemotherapy-associated drug on the immune response, quality of life and survival of dogs with mammary carcinoma

The objective of this study was to evaluate the effect of low-dose naltrexone (LDN) as a carboplatin chemotherapy-associated drug in female dogs with mammary carcinoma in benign mixed tumors (MC-BMT) after mastectomy and to assess its association with quality of life and survival rates. Sixty female dogs were included in this study, all of which had histopathological diagnosis of MC-BMT and were divided into three groups: G1 (control), consisting of animals submitted only to mastectomy with or without regional metastasis; G2, composed of treated animals that did not present with metastasis; and G3, treated dogs that presented with metastasis. G2 and G3 were also subdivided according to the treatment administered: chemotherapy alone (MC-BMT(-) C/MC-BMT(+) C) or LDN and chemotherapy (MC-BMT(-) C+LDN/MC-BMT(+) C+LDN). All animals were subjected to clinical evaluation, mastectomy, peripheral blood lymphocyte immunophenotyping, beta-endorphin and met-enkephalin quantification, and evaluation of survival rates and quality of life scores. The results showed higher serum concentrations of beta-endorphin and met-enkephalin, fewer chemotherapy-related side effects, and better quality of life and survival rates in the LDN-treated groups than in LDN-untreated groups (P < 0.05). Evaluation of clinical and pathological parameters indicated a significant association between the use of LDN and both prolonged survival and enhanced quality of life. These results indicate that LDN is a viable chemotherapy-associated treatment in female dogs with MC-BMT, maintaining their quality of life and prolonging survival rates.